Multiplicity of representation versus punctate localization in the motor cortex.

During the course of investigations of cortical motor function under the influence of pain impulses originating in the muscles (Gellhorn and Thompson1) and of afferent impulses from the hypothalamus (Murphy and Gellhorn2) it was observed that stimulation of a discrete focus with condenser discharges at threshold and suprathreshold intensities led to the production of multiple movements instead of isolated muscular contractions restricted to a small bodily subdivision, which have been described repeatedly. On the basis of these observations, it was decided to reinvestigate the question of multiplicity of motor representation versus punctate localization.3Experiments conducted in this study and their interpretation are the subject of the presentation which follows. A vast and detailed literature concerning motor cortical function has accumulated in the seventyfive years since Fritsch and Hitzig's4epochmaking discovery of the electrical excitability of this part of the brain. The communications of Fritsch and Hitzig

[1]  M. Kennard,et al.  RELATION OF AGE TO MOTOR IMPAIRMENT IN MAN AND IN SUBHUMAN PRIMATES , 1940 .

[2]  P. Bucy,et al.  IPSILATERAL REPRESENTATION IN THE MOTOR AND PREMOTOR CORTEX OP MONKEYS , 1933 .

[3]  F. M. R. Walshe,et al.  ON THE MODE OF REPRESENTATION OF MOVEMENTS IN THE MOTOR CORTEX, WITH SPECIAL REFERENCE TO “CONVULSIONS BEGINNING UNILATERALLY” (JACKSON) , 1943 .

[4]  M. Sapirstein.  CHARACTERISTICS OF AFTER-DISCHARGE FOLLOWING CORTICAL STIMULATION IN THE MONKEY , 1941 .

[5]  E D Adrian,et al.  The spread of activity in the cerebral cortex , 1936, The Journal of physiology.

[6]  M. Kennard.  Age and other factors in motor recovery from precentral lesions in monkeys. , 1936 .

[7]  H. W. Garol.  THE “MOTOR” CORTEX OF THE CAT , 1942 .

[8]  Victor Alexander Haden Horsley,et al.  A Minute Analysis (Experimental) of the Various Movements Produced by Stimulating in the Monkey Different Regions of the Cortical Centre for the Upper Limb, as Defined by Professor Ferrier , 1887 .

[9]  W. McCulloch,et al.  THE "MOTOR" CORTEX OF THE CHIMPANZEE , 1941 .

[10]  ON A RELEASE-PHENOMENON IN ELECTRICAL STIMULATION OF THE "MOTOR" CEREBRAL CORTEX. , 1931, Science.

[11]  Oswald Bumke,et al.  Handbuch der Neurologie , 1936 .

[12]  E. Gellhorn,et al.  Hypothalamic Facilitation of the Motor Cortex , 1945 .

[13]  W. McCulloch,et al.  MOTOR RESPONSE TO STIMULATION OF CEREBRAL CORTEX IN ABSENCE OF AREAS 4 AND 6 (MACACA MULATTA) , 1943 .

[14]  S. Hathaway,et al.  An action potential study of neuromuscular relations. , 1935 .

[15]  A. J. Derbyshire,et al.  THE EFFECTS OF ANESTHETICS ON ACTION POTENTIALS IN THE CEREBRAL CORTEX OF THE CAT , 1936 .

[16]  F. Mettler.  Corticifugal fiber connections of the cortex of Macaca Mullatta. The frontal region , 1935 .

[17]  J. G. D. D. Barenne.  CORTICALIZATION OF FUNCTION AND FUNCTIONAL LOCALIZATION IN THE CEREBRAL CORTEX , 1933 .

[18]  W. McCulloch,et al.  Functional Boundaries in the Sensori-Motor Cortex of the Monkey.∗ , 1936 .

[19]  W. Penfield,et al.  SOMATIC MOTOR AND SENSORY REPRESENTATION IN THE CEREBRAL CORTEX OF MAN AS STUDIED BY ELECTRICAL STIMULATION , 1937 .

[20]  G. Fleming.  Selected Writings of Sir Charles Sherrington , 1940 .

[21]  M. Hines.  MOVEMENTS ELICITED FROM PRECENTRAL GYRUS OF ADULT CHIMPANZEES BY STIMULATION WITH SINE WAVE CURRENTS , 1940 .

[22]  D. Denny-Brown,et al.  Responses to stimulation of the motor area of the cerebral cortex , 1927 .

[23]  J. de Barenne.  THE DISTURBANCES AFTER LAMINAR THERMO-COAGULATION OF THE MOTOR CEREBRAL CORTEX , 1934 .

[24]  P. Bucy.  THE RELATION OF THE PREMOTOR CORTEX TO MOTOR ACTIVITY , 1934 .

[25]  D. Ferrier.  The Functions of the Brain , 1887, Edinburgh Medical Journal.

[26]  A. Rosenblueth,et al.  CORTICAL RESPONSES TO ELECTRIC STIMULATION , 1942 .

[27]  F. Walshe.  THE GIANT CELLS OF BETZ, THE MOTOR CORTEX AND THE PYRAMIDAL TRACT: A CRITICAL REVIEW , 1942 .