Ras responsive element binding protein‐1 (RREB‐1) down‐regulates hZIP1 expression in prostate cancer cells

Normal prostate accumulates extremely high levels of zinc compared to other soft tissues. In contrast, the level of zinc in the prostate decreases significantly in prostate cancer. We have shown that down‐regulation of the expression of the zinc transporter hZIP1 in prostate cancer is an important event that is responsible for the decrease of zinc levels. However, the mechanism of hZIP1 down‐regulation is not known. We have hypothesized that hZIP1 is down‐regulated through transcriptional regulation.

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