论文信息 - Effects of estrogen replacement therapy on human brain aging: An in vivo 1H MRS study

Effects of estrogen replacement therapy on human brain aging: An in vivo 1H MRS study

Estrogen replacement therapy (ERT) may preserve cognitive function in postmenopausal women, but the mechanism is unknown. Thus, the authors studied aging of parietal lobe and hippocampus using proton MR spectroscopy. ERT naïve postmenopausal women had a significant increase in choline-containing compounds (Cho) compared to long-term ERT users and young women. Cho reflects increased neuronal/glial membrane turnover. Thus, ERT’s “neuroprotective” effect may include modulating the effects of age on neural integrity in brain regions involved in cognitive function.

[1] K O Lim,et al. In vivo spectroscopic quantification of the N‐acetyl moiety, creatine, and choline from large volumes of brain gray and white matter: Effects of normal aging , 1999, Magnetic resonance in medicine.

[2] E Moore,et al. Serial precision of metabolite peak area ratios and water referenced metabolite peak areas in proton MR spectroscopy of the human brain. , 1998, Magnetic resonance imaging.

[3] Yaakov Stern,et al. Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease , 1996, The Lancet.

[4] D J Jenden,et al. In vivo 1H MRS choline: correlation with in vitro chemistry/histology. , 1996, Life sciences.

[5] J. Joseph,et al. Membrane alterations as causes of impaired signal transduction in Alzheimer's disease and aging , 1995, Trends in Neurosciences.

[6] B Horwitz,et al. X-chromosome effects on female brain: a magnetic resonance imaging study of Turner's syndrome , 1993, The Lancet.

[7] B. Sherwin,et al. Effects of estrogen on memory function in surgically menopausal women , 1992, Psychoneuroendocrinology.

[8] L. G. Miller. Dietary choline alteration. Implications for gamma-aminobutyric acid and other neurotransmitter receptors. , 1990, Biochemical pharmacology.

[9] Robert A. Bornstein,et al. The Wechsler Memory Scale—Revised , 1990 .