Hybrid finite elements and spectral method for computation of the electric potential generated by a nerve cuff electrode

An original numerical method is developed to compute the 3D electric potential generated by a dot-contact cuff electrode implanted around an axisymmetrical, inhomogeneous, anisotropic nerve. The technique is based on a 2D finite-element approach coupled with a semi-analytical Fourier spectral decomposition to approximate the solution behaviour in the azymuthal direction. The method only requires a 2D FEM mesh and allows an accurate electrode description, with any number of contacts at different angular positions. Results show that the convergence of the Fourier series is very fast: typically, the relative error due to series truncation (estimated by the norm of the difference between the solution computed with M modes and the one computed with M— 1 modes, normalised by the norm of the solution computed with M modes) reaches the order of 10−3 with six spectral modes (M=6). As a consequence, the whole algorithm has the complexity of a 2D approach.

[1]  Guido Groeseneken,et al.  On the hot-carrier-induced post-stress interface trap generation in n-channel MOS transistors , 1994 .

[2]  E. V. Goodall,et al.  Modeling study of activation and propagation delays during stimulation of peripheral nerve fibers with a tripolar cuff electrode , 1995 .

[3]  Claude Gasquet,et al.  Analyse de Fourier et applications : filtrage, calcul numérique, ondelettes , 1990 .

[4]  J. Holsheimer,et al.  Selective stimulation of sacral nerve roots for bladder control: A study by computer modeling , 1994, IEEE Transactions on Biomedical Engineering.

[5]  J. Holsheimer,et al.  Transverse tripolar stimulation of peripheral nerve: a modelling study of spatial selectivity , 2006, Medical and Biological Engineering and Computing.

[6]  R. Plonsey,et al.  Development of a model for point source electrical fibre bundle stimulation , 1988, Medical and Biological Engineering and Computing.

[7]  J. T. Mortimer,et al.  A Numerical Analysis Of The Electric Field Generated By A Nerve Cuff Electrode , 1991, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society Volume 13: 1991.

[8]  D. A. Ksienski,et al.  A nerve cuff technique for selective excitation of peripheral nerve trunk regions , 1990, IEEE Transactions on Biomedical Engineering.

[9]  W. Grill,et al.  Electrical properties of implant encapsulation tissue , 2006, Annals of Biomedical Engineering.

[10]  J. Mortimer,et al.  Visual sensations produced by optic nerve stimulation using an implanted self-sizing spiral cuff electrode , 1998, Brain Research.

[11]  P.H. Veltink,et al.  Simulation of intrafascicular and extraneural nerve stimulation , 1988, IEEE Transactions on Biomedical Engineering.

[12]  W. Grill,et al.  Selective control of muscle activation with a multipolar nerve cuff electrode , 1993, IEEE Transactions on Biomedical Engineering.

[13]  Warren M. Grill,et al.  Stimulus waveforms for selective neural stimulation , 1995 .

[14]  Robert Plonsey,et al.  A Two-Part Model for Determining the Electromagnetic and Physiologic Behavior of Cuff Electrode Nerve Stimulators , 1986, IEEE Transactions on Biomedical Engineering.

[15]  L. Geddes,et al.  The specific resistance of biological material—A compendium of data for the biomedical engineer and physiologist , 1967, Medical and biological engineering.

[16]  O. Zienkiewicz,et al.  Finite elements and approximation , 1983 .