Synthesis and Antihypertensive Activity of Pyrimidin‐4(3H)‐one Derivatives as Losartan Analogue for New Angiotensin II Receptor Type 1 (AT1) Antagonists.

A series of losartan-like pyrimidin-4(3H)-one derivatives (I) are synthesized and evaluated as a novel class of AT1 receptor antagonists.