Oxicams as Bioactive Ligand System in Coordination Complexes and Their Biological Applications

[1]  Zohaib Saeed,et al.  An overview of Aniline-Based Schiff base metal Complexes: Synthesis, characterization and biological activities - a review , 2023, Inorganic Chemistry Communications.

[2]  Zohaib Saeed,et al.  Thiosemicarbazides, 1,3,4 thiadiazole Schiff base derivatives of transition metal complexes as antimicrobial agents , 2023, Inorganic Chemistry Communications.

[3]  Muhammad Mohsin Tahir,et al.  Structure Elucidation {Single X-ray Crystal diffraction Studies, Hirshfeld Surface Analysis, DFT} and Antibacterial Studies of Sulfonamide functionalized Schiff base Copper (II) and Zinc (II) Complexes , 2023, Journal of Molecular Structure.

[4]  A. M. Khedr,et al.  Nano‐sized Co(II), Ni(II), and Zr(IV) complexes of quinaldine‐based azo dye for promising therapeutic and catalytic applications: Synthesis, characterization, density functional theory studies and molecular docking , 2023, Applied Organometallic Chemistry.

[5]  M. Pervaiz,et al.  Schiff base derived Mn(II) and Cd(II) novel complexes for catalytic and antioxidant applications , 2023, Inorganic Chemistry Communications.

[6]  M. Pervaiz,et al.  Review: Schiff base metal complexes as anti-inflammatory agents , 2023, Journal of Coordination Chemistry.

[7]  A. M. Khedr,et al.  Copper based azo dye catalysts for phenoxazinone synthase mimicking efficiency: structure characterization and bioactivity evaluation , 2023, Arabian Journal of Chemistry.

[8]  M. Tahir,et al.  Crystal Structures, Hirshfeld Surface Analysis and DFT Studies of Sulfonamide Derived Schiff base Mn (II), Co (II) and Ni (II) Complexes , 2023, Applied Organometallic Chemistry.

[9]  M. Pervaiz,et al.  Synthesis, Characterization, Crystal Structure, Hirshfeld Surface Analysis and DFT of 1,2-benzothiazine Metal (II) Complexes , 2023, Journal of Molecular Structure.

[10]  C. Ferrer‐Luque,et al.  Antimicrobial Activity and Cytotoxicity of Nonsteroidal Anti-Inflammatory Drugs against Endodontic Biofilms , 2023, Antibiotics.

[11]  M. Hanif,et al.  Substitution of the chlorido ligand for PPh3 in anticancer organoruthenium complexes of sulfonamide functionalized pyridine-2-carbothioamides leads to high cytotoxic activity , 2022, Inorganica Chimica Acta.

[12]  A. M. Khedr,et al.  Nano-synthesis approach, elaborated spectral, biological activity and in silico assessment of novel nano-metal complexes based on sulfamerazine azo dye , 2022, Journal of Molecular Liquids.

[13]  A. M. Khedr,et al.  Nano‐synthesis, solid‐state structural characterization, and antimicrobial and anticancer assessment of new sulfafurazole azo dye‐based metal complexes for further pharmacological applications , 2021, Applied Organometallic Chemistry.

[14]  M. Pervaiz,et al.  Azo-Schiff base derivatives of transition metal complexes as antimicrobial agents , 2021 .

[15]  Muhammad Imran,et al.  Antibacterial metal complexes of o ‐sulfamoylbenzoic acid: Synthesis, characterization, and DFT study , 2021, Applied Organometallic Chemistry.

[16]  A. M. Khedr,et al.  Synthesis and characterization for new Zn(II) complexes and their optimizing fertilization performance in planting corn hybrid , 2021, Chemical Papers.

[17]  Tahani M. Bawazeer,et al.  Designed Anticancer Agent from VO(II) Complexes: Spectroscopic Characterization, Structural Optimization, and In Vitro and In Silico Assays towards Breast Cancer , 2020 .

[18]  A. M. Khedr,et al.  Synthesis and Elucidation for New Nanosized Cr(III)-Pyrazolin Complexes; Crystal Surface Properties, Antitumor Simulation Studies Beside Practical Apoptotic Path , 2020, Journal of Inorganic and Organometallic Polymers and Materials.

[19]  I. Camele,et al.  Biological and Spectroscopic Investigations of New Tenoxicam and 1.10-Phenthroline Metal Complexes , 2020, Molecules.

[20]  A. M. Khedr,et al.  Synthesis and characterization for novel Cu(II)-thiazole complexes-dyes and their usage in dyeing cotton to be special bandage for cancerous wounds , 2019, Journal of Molecular Structure.

[21]  Tahani M. Bawazeer,et al.  Synthesis of novel VO (II)‐thaizole complexes; spectral, conformational characterization, MOE‐docking and genotoxicity , 2019, Applied Organometallic Chemistry.

[22]  P. Prasher,et al.  Developmental perspectives of the drugs targeting enzyme-instigated inflammation: a mini review , 2019, Medicinal Chemistry Research.

[23]  F. Saad,et al.  Synthesis of new Cu(II)-benzohydrazide nanometer complexes, spectral, modeling, CT-DNA binding with potential anti-inflammatory and anti-allergic theoretical features. , 2019, Materials science & engineering. C, Materials for biological applications.

[24]  A. Yuzir,et al.  Electro-transformation of mefenamic acid drug: a case study of kinetics, transformation products, and toxicity , 2019, Environmental Science and Pollution Research.

[25]  M. Hanif,et al.  Structural Modifications of the Antiinflammatory Oxicam Scaffold and Preparation of Anticancer Organometallic Compounds , 2019, Organometallics.

[26]  O. Oprea,et al.  Synthesis, Characterization and Cytotoxic Activity of Co(II), Ni(II), Cu(II), and Zn(II) Complexes with Nonsteroidal Antiinflamatory Drug Isoxicam as Ligand , 2018, Journal of Inorganic and Organometallic Polymers and Materials.

[27]  Abdullah M. Asiri,et al.  Hybrid compounds from chalcone and 1,2-benzothiazine pharmacophores as selective inhibitors of alkaline phosphatase isozymes. , 2018, European journal of medicinal chemistry.

[28]  R. Boča,et al.  Impact of tetrahedral and square planar geometry of Ni(II) complexes with (pseudo)halide ligands to magnetic properties , 2018, Inorganica Chimica Acta.

[29]  Colin G. Cameron,et al.  Transition Metal Complexes and Photodynamic Therapy from a Tumor-Centered Approach: Challenges, Opportunities, and Highlights from the Development of TLD1433. , 2018, Chemical reviews.

[30]  A. M. Khedr,et al.  Characterization and thermal studies of nano‐synthesized Mn(II), Co(II), Ni(II) and Cu(II) complexes with adipohydrazone ligand as new promising antimicrobial and antitumor agents , 2017 .

[31]  M. Hanif,et al.  Anti-Inflammatory Oxicams as Multi-donor Ligand Systems: pH- and Solvent-Dependent Coordination Modes of Meloxicam and Piroxicam to Ru and Os. , 2017, Chemistry.

[32]  P. Sadler,et al.  Redox‐Active Metal Complexes for Anticancer Therapy , 2017 .

[33]  F. J. Caires,et al.  Synthesis, characterization, thermal and spectroscopic studies and bioactivity of complexes of meloxicam with some bivalent transition metals , 2017, Journal of Thermal Analysis and Calorimetry.

[34]  A. El-Sherif,et al.  Mixed-ligand complex formation of tenoxicam drug with some transition metal ions in presence of valine: Synthesis, characterization, molecular docking, potentiometric and evaluation of the humeral immune response of calves , 2016 .

[35]  Mark E. Scott,et al.  Synthesis and Antimicrobial Activity of 1,2-Benzothiazine Derivatives , 2016, Molecules.

[36]  M. Saeed,et al.  Piroxicam sulfonates biology-oriented drug synthesis (BIODS), characterization and anti-nociceptive screening , 2016, Medicinal Chemistry Research.

[37]  H. Krautscheid,et al.  Metal complexes of benzimidazole derived sulfonamide: Synthesis, molecular structures and antimicrobial activity , 2016 .

[38]  Hannah U. Holtkamp,et al.  RuII(η6‐p‐cymene) Complexes of Bioactive 1,2‐Benzothiazines: Protein Binding vs. Antitumor Activity , 2016 .

[39]  S. Mor,et al.  Efficient and convenient synthesis, characterization, and antimicrobial evaluation of some new tetracyclic 1,4-benzothiazines , 2016 .

[40]  Harun Muslu,et al.  New metal based drug as a therapeutic agent: Spectral, electrochemical, DNA-binding, surface morphology and photoluminescence properties , 2015 .

[41]  B. Keppler,et al.  Half-sandwich ruthenium(II) biotin conjugates as biological vectors to cancer cells. , 2015, Chemistry.

[42]  G. Mohamed,et al.  Synthesis, structural characterization, in vitro antimicrobial and anticancer activity studies of ternary metal complexes containing glycine amino acid and the anti-inflammatory drug lornoxicam , 2015 .

[43]  T. Khayamian,et al.  A mononuclear zinc(II) complex with piroxicam: crystal structure, DNA- and BSA-binding studies; in vitro cell cytotoxicity and molecular modeling of oxicam complexes. , 2015, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[44]  I. Demirtaş,et al.  New metal based drugs: spectral, electrochemical, DNA-binding, surface morphology and anticancer activity properties. , 2015, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[45]  L. Marnett,et al.  Oxicams, a class of nonsteroidal anti‐inflammatory drugs and beyond , 2014, IUBMB life.

[46]  T. Khayamian,et al.  Characterization, photocleavage, molecular modeling, and DNA- and BSA-binding studies of Cu(II) and Ni(II) complexes with the non-steroidal anti-inflammatory drug meloxicam , 2014 .

[47]  M. Hanif,et al.  Anticancer Ruthenium(η 6 - p -cymene) Complexes of Nonsteroidal Anti-inflammatory Drug Derivatives , 2014 .

[48]  G. Tamasi,et al.  Synthesis, and Electrochemical and Density Functional Studies of New Copper(II)- and Manganese(II) Oxicam Drugs. Redox Potentials and MOs Compatible with SOD-like Activity and Unusual Six-membered Rings of Water Molecules Bridging Complex Units , 2014 .

[49]  G. Mohamed,et al.  Coordination modes of bidentate lornoxicam drug with some transition metal ions. Synthesis, characterization and in vitro antimicrobial and antibreastic cancer activity studies. , 2014, Spectrochimica Acta Part A - Molecular and Biomolecular Spectroscopy.

[50]  M. Sarkar,et al.  Spectroscopic studies of the binding of Cu(II) complexes of oxicam NSAIDs to alternating G-C and homopolymeric G-C sequences. , 2014, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[51]  A. Banerjee,et al.  The DNA intercalators ethidium bromide and propidium iodide also bind to core histones , 2014, FEBS open bio.

[52]  H. Hadadzadeh,et al.  The meloxicam complexes of Co(II) and Zn(II): Synthesis, crystal structures, photocleavage and in vitro DNA-binding , 2013 .

[53]  D. Hardie,et al.  AMPK: mediating the metabolic effects of salicylate-based drugs? , 2013, Trends in Endocrinology & Metabolism.

[54]  N. Metzler‐Nolte,et al.  Biologically Active Trifluoromethyl-Substituted Metallocene Triazoles: Characterization, Electrochemistry, Lipophilicity, and Cytotoxicity , 2012 .

[55]  Zia-ur-Rehman,et al.  Synthesis, characterization and DNA binding studies of organoantimony(V) ferrocenyl benzoates , 2012, Journal of Organometallic Chemistry.

[56]  H. Hadadzadeh,et al.  A mononuclear copper(II) complex based on the polypyridyl ligand 2,4,6-tris(2-pyridyl)-1,3,5-triazine (tptz), [Cu(tptz)2]2+: X-ray crystal structure, DNA binding and in vitro cell cytotoxicity , 2012 .

[57]  H. Hadadzadeh,et al.  The piroxicam complex of copper(II), trans-[Cu(Pir)2(THF)2], and its interaction with DNA , 2012 .

[58]  B. Narasimhan,et al.  Synthesis, characterization, antimicrobial activities and QSAR studies of some 10a-phenylbenzo[b]indeno[1,2-e][1,4]thiazin-11(10aH)-ones. , 2012, European journal of medicinal chemistry.

[59]  M. Lotfy,et al.  4-Hydroxy-2-methyl-N-(2-thiazole)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide (EX15) and its Cu(II) Complex as New Oxicam Selective Cyclooxygenase-2 Inhibitors , 2012 .

[60]  H. Hadadzadeh,et al.  Mononuclear copper(II) complex with terpyridine and an extended phenanthroline base, [Cu(tpy)(dppz)]2+: Synthesis, crystal structure, DNA binding and cytotoxicity activity , 2012 .

[61]  G. Mohamed,et al.  Ligational behaviour of lomefloxacin drug towards Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Th(IV) and UO(2)(VI) ions: synthesis, structural characterization and biological activity studies. , 2011, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[62]  S. Ozkan,et al.  A novel sensitive electrochemical DNA biosensor for assaying of anticancer drug leuprolide and its adsorptive stripping voltammetric determination. , 2011, Talanta.

[63]  G. Gasser,et al.  Organometallic Anticancer Compounds , 2010, Journal of medicinal chemistry.

[64]  Mahmoud Labib,et al.  Is the reactivity of M(II)-arene complexes of 3-hydroxy-2(1H)-pyridones to biomolecules the anticancer activity determining parameter? , 2010, Inorganic Chemistry.

[65]  Suresh Kumar,et al.  Biological activities of quinoline derivatives. , 2009, Mini reviews in medicinal chemistry.

[66]  N. El-Gamel,et al.  The interactions of metal ions with nonsteroidal anti-inflammatory drugs (oxicams) , 2009 .

[67]  M. Starek,et al.  A review of analytical techniques for determination of oxicams, nimesulide and nabumetone. , 2009, Talanta.

[68]  M. Casolaro,et al.  Release studies from smart hydrogels as carriers for piroxicam and copper(II)-oxicam complexes as anti-inflammatory and anti-cancer drugs. X-ray structures of new copper(II)-piroxicam and -isoxicam complex molecules. , 2008, Journal of inorganic biochemistry.

[69]  D. Gerlach,et al.  Uranyl and transition metal chelates of tenoxicam. Crystal structures of trans,trans -[Co(II)(Hten)2(dmso)2], trans , trans -[Zn(II)(Hten)2(dmso)2] and cis , cis -[UO2(VI)(Hten)2(H2O)] · 2C2H5OH , 2008 .

[70]  S. Alvarez,et al.  Stereochemistry and spin state in four-coordinate transition metal compounds. , 2008, Inorganic chemistry.

[71]  R. Varma,et al.  Greener and expeditious synthesis of bioactive heterocycles using microwave irradiation , 2008 .

[72]  N. El-Gamel,et al.  Uranyl binary and ternary chelates of tenoxicam Synthesis, spectroscopic and thermal characterization of ternary chelates of tenoxicam and alanine with transition metals. , 2007, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[73]  M. El-abadelah,et al.  Synthesis and Antibacterial Potency of 4-Methyl-2,7-dioxo-1,2,3,4,7,10- hexahydropyrido[2,3-ƒ]quinoxaline-8-carboxylic acid, Selected [a]-Fused Heterocyles and Acyclic Precursors , 2007 .

[74]  Michael B Hursthouse,et al.  Unusual coordinating behavior by three non-steroidal anti-inflammatory drugs from the oxicam family towards copper(II). Synthesis, X-ray structure for copper(II)-isoxicam, -meloxicam and -cinnoxicam-derivative complexes, and cytotoxic activity for a copper(II)-piroxicam complex. , 2007, Journal of inorganic biochemistry.

[75]  G. Mohamed,et al.  Metal complexes of Schiff base derived from sulphametrole and o-vanilin. Synthesis, spectral, thermal characterization and biological activity. , 2007, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[76]  Jamil Anwar Choudary,et al.  Synthesis of potential biologically active 1,2-benzothiazin-3-yl-quinazolin-4(3H)-ones. , 2006, Chemical & pharmaceutical bulletin.

[77]  M. Zayed,et al.  Synthesis and thermal characterization of new ternary chelates of piroxicam and tenoxicam with glycine and DL-phenylalanine and some transition metals. , 2006, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[78]  G. Mohamed Structural and thermal characterization of ternary complexes of piroxicam and alanine with transition metals: uranyl binary and ternary complexes of piroxicam. Spectroscopic characterization and properties of metal complexes. , 2005, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[79]  G. Psomas,et al.  Mononuclear metal complexes with piroxicam: synthesis, structure and biological activity. , 2005, Journal of inorganic biochemistry.

[80]  G. Mohamed,et al.  Synthesis, investigation and spectroscopic characterization of piroxicam ternary complexes of Fe(II), Fe(III), Co(II), Ni(II), Cu(II) and Zn(II) with glycine and DL-phenylalanine. , 2004, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[81]  G. Gehad,et al.  Preparation and spectroscopic characterisation of metal complexes of piroxicam , 2004 .

[82]  M. Zayed,et al.  Structure investigation, spectral, thermal, X-ray and mass characterization of piroxicam and its metal complexes. , 2004, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[83]  E. Korpi,et al.  Receptor subtype-dependent positive and negative modulation of GABA(A) receptor function by niflumic acid, a nonsteroidal anti-inflammatory drug. , 2003, Molecular pharmacology.

[84]  M. Kubicki,et al.  Organotin-Drug Interactions. Organotin Adducts of Lornoxicam, Synthesis and Characterisation of the First Complexes of Lornoxicam , 2003 .

[85]  R. Cini,et al.  Synthesis, X-ray structure and molecular modelling analysis of cobalt(II), nickel(II), zinc(II) and cadmium(II) complexes of the widely used anti-inflammatory drug meloxicam , 2002 .

[86]  E. Baran,et al.  Vibrational Spectrum of a Platinum Complex of Piroxicam , 1999 .

[87]  R. Poli Open-Shell Organometallics as a Bridge between Werner-Type and Low-Valent Organometallic Complexes. The Effect of the Spin State on the Stability, Reactivity, and Structure. , 1996, Chemical reviews.

[88]  C. Rossi,et al.  Metal complexes of the antiinflammatory drug piroxicam , 1990 .

[89]  N. Turro,et al.  Mixed-ligand complexes of ruthenium(II): factors governing binding to DNA , 1989 .

[90]  J. Lombardino,et al.  Synthesis and antiinflammatory activity of some 3-carboxamides of 2-alkyl-4-hydroxy-2H-1,2-benzothiazine 1,1-dioxide. , 1971, Journal of medicinal chemistry.

[91]  J. V. Braun Über Benzo‐polymethylen‐Verbindungen, X.: Oxydativer Abbau von Tetralin und substituierten Tetralinen zu Phthalonsäuren und Phthalsäuren , 1923 .

[92]  T. Khayamian,et al.  The piroxicam complex of cobalt(II); synthesis in two different ionic liquids, structure, DNA- and BSA interaction and molecular modeling , 2014 .

[93]  P. Fey,et al.  Extended Spectrum β-Lactamase (ESBL)-Producing Enterobacteriaceae , 2012, Drugs.

[94]  C. Moote Efficacy of Nonsteroidal Anti-Inflammatory Drugs in the Management of Postoperative Pain , 2012, Drugs.

[95]  A. Bryskier,et al.  Classification and Structure-Activity Relationships of Fluoroquinolones , 2012, Drugs.

[96]  Jun-Ming Zhang,et al.  Nonopioid analgesics. , 2007, Anesthesiology clinics.

[97]  J. Vane,et al.  Mechanism of action of anti-inflammatory drugs. , 1997, Advances in experimental medicine and biology.

[98]  K. Matsui,et al.  A New Method for the Preparation of Secondary Amines. VIII: Synthesis of Phenylalkanolamines@@@フェニルアルカノールアミンの合成 , 1956 .