Photocatalytic Synthesis of Materials for Regenerative Medicine Using Complex Oxides with β-pyrochlore Structure

Graft copolymerization of methyl methacrylate onto cod collagen was carried out under visible light irradiation (λ = 400–700 nm) at 20–25 °C using the RbTe1.5W0.5O6, CsTeMoO6, and RbNbTeO6 complex oxides with β-pyrochlore structure as photocatalysts. The as-prepared materials were characterized by X-ray diffraction, scanning electron microscopy, and UV-Vis diffuse reflectance spectroscopy. It was also found that RbNbTeO6 with β-pyrochlore structure was not able to photocatalyze the reaction. Enzymatic hydrolysis of the obtained graft copolymers proceeds with the formation of peptides with a molecular weight (MW) of about 20 and 10 kDa. In contrast to collagen, which decomposes predominantly to peptides with MW of about 10 kDa, the ratio of fractions with MW of about 10 kDa and 20 kDa differs much less, their changes are symbatic, and the content of polymers with MW of more than 20 kDa is about 70% after 1 h in the case of graft copolymers. The data obtained indicate that synthetic fragments grafted to the collagen macromolecule do not prevent the hydrolysis of the peptide bonds but change the rate of polymer degradation. This is important for creating network matrix scaffolds based on graft copolymers by cross-linking peptides, which are products of enzymatic hydrolysis.

[1]  E. Suleimanov,et al.  Visible light-induced degradation of organic dyes by niobium tellurium oxides ANbTeO6 (A = Rb, Cs) with β-pyrochlore structure , 2022, Materials Letters.

[2]  A. P. Gorshkov,et al.  Regulating of MnO2 photocatalytic activity in degradation of organic dyes by polymorphic engineering , 2022, Solid State Sciences.

[3]  Shin‐ya Takizawa,et al.  Photofunctional molecular assembly for artificial photosynthesis: Beyond a simple dye sensitization strategy , 2022, Coordination Chemistry Reviews.

[4]  S. Haider,et al.  Influence of the Physical Inclusion of ZrO2/TiO2 Nanoparticles on Physical, Mechanical, and Morphological Characteristics of PMMA-Based Interim Restorative Material , 2022, BioMed research international.

[5]  F. Ozel,et al.  Scheelite-type BaMoO4 and BaWO4 based dye sensitized photocatalytic hydrogen evolution by water splitting , 2022, Journal of Physics and Chemistry of Solids.

[6]  Chuanruo Yang,et al.  LiXO2(X = Co, Rh, Ir) and solar light photocatalytic water splitting for hydrogen generation. , 2022, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[7]  N. A. Ludin,et al.  An overview of co‐catalysts on metal oxides for photocatalytic water splitting , 2022, International Journal of Energy Research.

[8]  D. Fukina,et al.  Features of the electronic structure and photocatalytic properties under visible light irradiation for RbTe1.5W0.5O6 with β-pyrochlore structure , 2022, Solid State Sciences.

[9]  M. Egorikhina,et al.  Cod Gelatin as an Alternative to Cod Collagen in Hybrid Materials for Regenerative Medicine , 2022, Macromolecular Research.

[10]  N. Valetova,et al.  Synthesis of Polymethyl-Methacrylate–Collagen-Graft Copolymer Using a Complex Oxide RbTe1.5W0.5O6 Photocatalyst , 2022, Polymer Science, Series D.

[11]  B. Fang,et al.  Properties, optimized morphologies, and advanced strategies for photocatalytic applications of WO3 based photocatalysts. , 2022, Journal of hazardous materials.

[12]  S. Han,et al.  Peptide ligases: A Novel and potential enzyme toolbox for catalytic cross-linking of protein/peptide-based biomaterial scaffolds for tissue engineering. , 2022, Enzyme and microbial technology.

[13]  B. Ni,et al.  Defect engineering of oxide perovskites for catalysis and energy storage: synthesis of chemistry and materials science. , 2021, Chemical Society reviews.

[14]  E. A. Zakharychev,et al.  Changes in the Molecular Characteristics of Bovine and Marine Collagen in the Presence of Proteolytic Enzymes as a Stage Used in Scaffold Formation , 2021, Marine drugs.

[15]  F. Kapteijn,et al.  Surface functionalized N-C-TiO2/C nanocomposites derived from metal-organic framework in water vapour for enhanced photocatalytic H2 generation , 2021 .

[16]  Can Li,et al.  Surface assembly of cobalt species for simultaneous acceleration of interfacial charge separation and catalytic reactions on Cd0.9Zn0.1S photocatalyst , 2021, Chinese Journal of Catalysis.

[17]  Ying Chen,et al.  Switching between Thermal Initiation and Photoinitiation Redirects RAFT-Mediated Polymerization-Induced Self-Assembly , 2021 .

[18]  J. Lalevée,et al.  Radical photoinitiation with LEDs and applications in the 3D printing of composites. , 2021, Chemical Society reviews.

[19]  E. Suleimanov,et al.  Features of Polymerization of Methyl Methacrylate using a Photocatalyst—the Complex Oxide RbTe1.5W0.5O6 , 2021, Journal of Inorganic and Organometallic Polymers and Materials.

[20]  O. Pandey,et al.  Group V Elements (V, Nb and Ta) Doped CeO2 Particles for Efficient Photo-Oxidation of Methylene Blue Dye , 2020, Journal of Inorganic and Organometallic Polymers and Materials.

[21]  H. Ding,et al.  A review: Synthesis, modification and photocatalytic applications of ZnIn2S4 , 2020, Journal of Materials Science & Technology.

[22]  W. Mao,et al.  Fabrication of highly efficient Bi2WO6/CuS composite for visible-light photocatalytic removal of organic pollutants and Cr(VI) from wastewater , 2020, Frontiers of Environmental Science & Engineering.

[23]  A. Markin,et al.  Synthesis of Biodegradable Grafted Copolymers of Gelatin and Polymethyl Methacrylate , 2020, Polymer Science, Series D.

[24]  M. Sadjadi,et al.  Synthesis and Characterization of a Perovskite Nanocomposite of CdTiO3@S with Orthorhombic Structure: Investigation of Photoluminescence Properties and Its Photocatalytic Performance for the Degradation of Congo Red and Crystal Violet Under Sunlight , 2020, Journal of Inorganic and Organometallic Polymers and Materials.

[25]  Hui Wang,et al.  Study on Ag2WO4/g-C3N4 Nanotubes as an Efficient Photocatalyst for Degradation of Rhodamine B , 2020, Journal of Inorganic and Organometallic Polymers and Materials.

[26]  M. D. Domenico,et al.  Synthesis, characterization, and application of polypyrrole/TiO2 composites in photocatalytic processes: A review , 2020 .

[27]  Hafiz M.N. Iqbal,et al.  TiO2 Nanoparticles and Epoxy-TiO2 Nanocomposites: A Review of Synthesis, Modification Strategies, and Photocatalytic Potentialities , 2020, Journal of Inorganic and Organometallic Polymers and Materials.

[28]  Yu-hua Fan,et al.  Three Different Co(II) Metal–Organic Frameworks Based on 4,4′-Bis(imidazolyl)diphenyl Ether: Syntheses, Crystal Structure and Photocatalytic Properties , 2020, Journal of Inorganic and Organometallic Polymers and Materials.

[29]  Zhijun Ren,et al.  Historical development and prospects of photocatalysts for pollutant removal in water. , 2020, Journal of hazardous materials.

[30]  A. Mitin,et al.  Enzymatic Hydrolysis of Marine Collagen and Fibrinogen Proteins in the Presence of Thrombin , 2020, Marine drugs.

[31]  L. Semenycheva,et al.  Molecular Weight Parameters of Collagen from Different Feedstock and Dynamics of Their Change upon Enzymatic Hydrolysis by Pancreatin , 2020, Polymer Science, Series D.

[32]  B. Nair,et al.  Polymethyl methacrylate (PMMA) grafted collagen scaffold reinforced by PdO-TiO2 nanocomposites. , 2020, Materials science & engineering. C, Materials for biological applications.

[33]  H. P. Nagaswarupa,et al.  Enhanced photocatalytic and electrochemical performance of TiO2-Fe2O3 nanocomposite: Its applications in dye decolorization and as supercapacitors , 2020, Scientific Reports.

[34]  L. Semenycheva,et al.  Enzymatic hydrolysis of collagen by pancreatin and thrombin as a step in the formation of scaffolds , 2020, Russian Chemical Bulletin.

[35]  M. Bugrova,et al.  Hydrogel scaffolds based on blood plasma cryoprecipitate and collagen derived from various sources: Structural, mechanical and biological characteristics , 2019, Bioactive materials.

[36]  Ruizhen Guo,et al.  A review of visible light-active photocatalysts for water disinfection: Features and prospects , 2019, Chemical Engineering Journal.

[37]  Z. Cui,et al.  Manufacture and characterisation of EmDerm—novel hierarchically structured bio-active scaffolds for tissue regeneration , 2018, Journal of Materials Science: Materials in Medicine.

[38]  J. Malda,et al.  Mechanical behavior of a soft hydrogel reinforced with three-dimensional printed microfibre scaffolds , 2018, Scientific Reports.

[39]  S. Qin,et al.  Purification and Structural Aspects of Type I Collagen from Walleye Pollock (Theragra chalcogramma) Skin , 2017 .

[40]  E. Oliveros,et al.  Colloidal and Supported TiO2: Toward Nonextractable and Recyclable Photocatalysts for Radical Polymerizations in Aqueous Dispersed Media , 2016 .

[41]  Yonggang Lv,et al.  Application of Collagen Scaffold in Tissue Engineering: Recent Advances and New Perspectives , 2016, Polymers.

[42]  Dietmar W. Hutmacher,et al.  Enhancing structural integrity of hydrogels by using highly organised melt electrospun fibre constructs , 2015 .

[43]  Bruce P. Lee,et al.  Fibrin Gel as an Injectable Biodegradable Scaffold and Cell Carrier for Tissue Engineering , 2015, TheScientificWorldJournal.

[44]  Людмила Леонидовна Семенычева,et al.  Method for production of acetic dispersion of high molecular fish collagen , 2014 .

[45]  Pilar de la Puente,et al.  Cell culture in autologous fibrin scaffolds for applications in tissue engineering. , 2014, Experimental cell research.

[46]  S. Fujisawa,et al.  Tri-n-Butylborane/WaterComplex-Mediated Copolymerization of Methyl Methacrylate with Proteinaceous Materials and Proteins: A Review , 2010 .

[47]  L. Byers The bioorganic chemistry of enzymatic catalysis , 1985 .

[48]  A. P. Gorshkov,et al.  Structure analysis and electronic properties of ATe4+0.5Te6+1.5-xM6+xO6 (A=Rb, Cs, M6+=Mo, W) solid solutions with β-pyrochlore structure , 2021 .

[49]  A. V. Mitin,et al.  Efficacy of Pancreatin and Trypsin Proteases in Enzymatic Hydrolysis of Collagen , 2020, Bulletin of the South Ural State University series "Chemistry".

[50]  G. Zengin,et al.  CHARACTERIZATION OF COLLAGEN DERIVED PRODUCTS PREPARED BY USE OF ALKALI AND DAIRY BY-PRODUCT , 2019, Environmental Engineering and Management Journal.

[51]  T. Frączyk,et al.  Effect of enzymatic hydrolysis on surface activity and surface rheology of type I collagen. , 2016, Colloids and surfaces. B, Biointerfaces.