PCSK9 regulates pyroptosis via mtDNA damage in chronic myocardial ischemia

[1]  J. Mehta,et al.  NLRP3 inflammasome via IL-1β regulates PCSK9 secretion , 2020, Theranostics.

[2]  G. Dubyak,et al.  N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis , 2020, Nature Communications.

[3]  Jia Hu,et al.  NLRP3 inflammasome-mediated pyroptosis contributes to the pathogenesis of non-ischemic dilated cardiomyopathy , 2020, Redox biology.

[4]  A. Poltorak,et al.  cFLIPL protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation , 2020, Science.

[5]  J. Lupón,et al.  Role of PCSK9 in the course of ejection fraction change after ST‐segment elevation myocardial infarction: a pilot study , 2020, ESC heart failure.

[6]  S. Saito,et al.  Pyroptosis is a critical inflammatory pathway in the placenta from early onset preeclampsia and in human trophoblasts exposed to hypoxia and endoplasmic reticulum stressors , 2019, Cell Death & Disease.

[7]  J. Mehta,et al.  Blood flow patterns regulate PCSK9 secretion via MyD88 mediated proinflammatory cytokines. , 2019, Cardiovascular research.

[8]  A. Gotto,et al.  PCSK9 and inflammation: a review of experimental and clinical evidence. , 2019, European heart journal. Cardiovascular pharmacotherapy.

[9]  N. Chattipakorn,et al.  PCSK9 inhibitor improves cardiac function and reduces infarct size in rats with ischaemia/reperfusion injury: Benefits beyond lipid‐lowering effects , 2019, Journal of cellular and molecular medicine.

[10]  Masafumi Takahashi.  Cell-Specific Roles of NLRP3 Inflammasome in Myocardial Infarction. , 2019, Journal of cardiovascular pharmacology.

[11]  Z. Xia,et al.  Propofol directly induces caspase-1-dependent macrophage pyroptosis through the NLRP3-ASC inflammasome , 2019, Cell Death & Disease.

[12]  F. Shao,et al.  Innate immunity to intracellular LPS , 2019, Nature Immunology.

[13]  Zan Huang,et al.  Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation , 2019, Journal of molecular cell biology.

[14]  J. Mehta,et al.  PCSK9 expression in the ischaemic heart and its relationship to infarct size, cardiac function, and development of autophagy , 2018, Cardiovascular research.

[15]  J. Mehta,et al.  PCSK9 regulates expression of scavenger receptors and ox-LDL uptake in macrophages , 2018, Cardiovascular research.

[16]  J. Mehta,et al.  Inflammation, Autophagy, and Apoptosis After Myocardial Infarction , 2018, Journal of the American Heart Association.

[17]  M. Adorni,et al.  PCSK9 induces a pro-inflammatory response in macrophages , 2018, Scientific Reports.

[18]  R. Schulz,et al.  Oxidized low-density lipoprotein (oxLDL) affects load-free cell shortening of cardiomyocytes in a proprotein convertase subtilisin/kexin 9 (PCSK9)-dependent way , 2017, Basic Research in Cardiology.

[19]  Si Ming Man,et al.  Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases , 2017, Immunological reviews.

[20]  J. Mehta,et al.  Role of NLRP3 inflammasome in the pathogenesis of cardiovascular diseases , 2017, Basic Research in Cardiology.

[21]  J. Mehta,et al.  Cross-Talk Between PCSK9 and Damaged mtDNA in Vascular Smooth Muscle Cells: Role in Apoptosis. , 2016, Antioxidants & redox signaling.

[22]  A. Sahebkar,et al.  Effect of monoclonal antibodies to PCSK9 on high-sensitivity C-reactive protein levels: a meta-analysis of 16 randomized controlled treatment arms. , 2016, British journal of clinical pharmacology.

[23]  Patrick W Serruys,et al.  PCSK9 in relation to coronary plaque inflammation: Results of the ATHEROREMO-IVUS study. , 2016, Atherosclerosis.

[24]  Lesley Burgess,et al.  PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial , 2015, The Lancet.

[25]  A. Quyyumi,et al.  Plasma PCSK9 Levels Are Elevated with Acute Myocardial Infarction in Two Independent Retrospective Angiographic Studies , 2014, PloS one.

[26]  A. Wree,et al.  NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice , 2014, Hepatology.

[27]  D. Yellon,et al.  Myocardial ischemia-reperfusion injury: a neglected therapeutic target. , 2013, The Journal of clinical investigation.

[28]  J. Mehta,et al.  Abrogation of lectin-like oxidized LDL receptor-1 attenuates acute myocardial ischemia-induced renal dysfunction by modulating systemic and local inflammation. , 2012, Kidney international.

[29]  O. Palyha,et al.  Discovery of a new role of human resistin in hepatocyte low-density lipoprotein receptor suppression mediated in part by proprotein convertase subtilisin/kexin type 9. , 2012, Journal of the American College of Cardiology.

[30]  E. Fisher,et al.  Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[31]  Lawrence Buja,et al.  Modes of myocardial cell injury and cell death in ischemic heart disease. , 1998, Circulation.

[32]  M. Rekhter,et al.  Graft permeabilization facilitates gene therapy of transplant arteriosclerosis in a rabbit model. , 1998, Circulation.