Activation of Wnt/β‐catenin signaling in a subpopulation of murine prostate luminal epithelial cells induces high grade prostate intraepithelial neoplasia

Wnt/β‐catenin signaling is important for prostate development and cancer in humans. Activation of this pathway in differentiated luminal cells of mice induces high‐grade prostate intraepithelial neoplasia (HGPIN). Though the cell of origin of prostate cancer has yet to be conclusively identified, a castration‐resistant Nkx3.1‐expressing cell (CARN) may act as a cell of origin for prostate cancer.

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