Evidence of intrinsic differences in the light scattering properties of tumorigenic and nontumorigenic cells

The objective of this study was to determine whether there are intrinsic differences in the light scattering properties of tumorigenic and nontumorigenic cells from a multistep carcinogenesis model.

[1]  William S. Bickel,et al.  Stokes vectors, Mueller matrices, and polarized scattered light , 1985 .

[2]  N Ramanujam,et al.  Development of a multivariate statistical algorithm to analyze human cervical tissue fluorescence spectra acquired in vivo , 1996, Lasers in surgery and medicine.

[3]  B. Wilson,et al.  A diffusion theory model of spatially resolved, steady-state diffuse reflectance for the noninvasive determination of tissue optical properties in vivo. , 1992, Medical physics.

[4]  J. Fujimoto,et al.  In vivo endoscopic optical biopsy with optical coherence tomography. , 1997, Science.

[5]  J Beuthan,et al.  The spatial variation of the refractive index in biological cells. , 1996, Physics in medicine and biology.

[6]  L. O. Svaasand,et al.  Boundary conditions for the diffusion equation in radiative transfer. , 1994, Journal of the Optical Society of America. A, Optics, image science, and vision.

[7]  L Kunzschughart,et al.  Oncogene-associated transformation of rodent fibroblasts is accompanied by large morphologic and metabolic alterations. , 1995, Oncology reports.

[8]  J. Freyer,et al.  Differential regulation of cyclin-dependent kinase inhibitors in monolayer and spheroid cultures of tumorigenic and nontumorigenic fibroblasts. , 1998, Cancer research.

[9]  E. Sevick-Muraca,et al.  Quantitative optical spectroscopy for tissue diagnosis. , 1996, Annual review of physical chemistry.

[10]  Angela A. Eick,et al.  Mechanisms of light scattering from biological cells relevant to noninvasive optical-tissue diagnostics. , 1998, Applied optics.

[11]  A. Welch,et al.  A review of the optical properties of biological tissues , 1990 .

[12]  R. Steiner,et al.  Spatially resolved absolute diffuse reflectance measurements for noninvasive determination of the optical scattering and absorption coefficients of biological tissue. , 1996, Applied optics.

[13]  Robert A. Weinberg,et al.  Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes , 1983, Nature.

[14]  E R Anderson,et al.  Frequency-domain photon migration measurements of normal and malignant tissue optical properties in a human subject. , 1997, Applied optics.

[15]  Rick E. Sneed,et al.  In vivo cancer diagnosis of the esophagus using differential normalized fluorescence (DNF) indices , 1995, Lasers in surgery and medicine.

[16]  I J Bigio,et al.  Spectroscopic diagnosis of bladder cancer with elastic light scattering , 1995, Lasers in surgery and medicine.

[17]  J. Fisher.  Photons, physiatrics, and physicians: a practical guide to understanding laser light interaction with living tissue, part I. , 1992, Journal of clinical laser medicine & surgery.

[18]  Michael B. Wallace,et al.  Observation of periodic fine structure in reflectance from biological tissue: A new technique for measuring nuclear size distribution , 1998 .

[19]  A H Hielscher,et al.  Influence of particle size and concentration on the diffuse backscattering of polarized light from tissue phantoms and biological cell suspensions. , 1997, Applied optics.

[20]  H. J. van Staveren,et al.  Light scattering in Intralipid-10% in the wavelength range of 400-1100 nm. , 1991, Applied optics.

[21]  A Hielscher,et al.  Diffuse backscattering Mueller matricesof highly scattering media. , 1997, Optics express.

[22]  T J Flotte,et al.  Ultraviolet laser‐induced fluorescence of colonic tissue: Basic biology and diagnostic potential , 1992, Lasers in surgery and medicine.

[23]  J. Mourant,et al.  Ultraviolet and visible spectroscopies for tissue diagnostics: fluorescence spectroscopy and elastic-scattering spectroscopy. , 1997, Physics in medicine and biology.

[24]  J M Schmitt,et al.  Turbulent nature of refractive-index variations in biological tissue. , 1996, Optics letters.

[25]  T. Kitai,et al.  Contribution of the mitochondrial compartment to the optical properties of the rat liver: a theoretical and practical approach. , 1994, Biophysical journal.

[26]  Britton Chance,et al.  Influence of blood vessels on the measurement of hemoglobin oxygenation as determined by time-resolved reflectance spectroscopy. , 1995, Medical physics.

[27]  J. Mourant,et al.  Elastic scattering spectroscopy as a diagnostic tool for differentiating pathologies in the gastrointestinal tract: preliminary testing. , 1996, Journal of biomedical optics.