All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3.

[1]  M. Scott,et al.  Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification. , 2003, Developmental biology.

[2]  W. Talbot,et al.  Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development , 2003, Development.

[3]  C. Hui,et al.  Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development. , 2003, Genes & development.

[4]  Jens Böse,et al.  Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity. , 2002, Genes & development.

[5]  A. McMahon,et al.  A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. , 2002, Genes & development.

[6]  A. Joyner,et al.  A novel gene, GliH1, with homology to the Gli zinc finger domain not required for mouse development , 2002, Mechanisms of Development.

[7]  A. Joyner,et al.  Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway. , 2002, Development.

[8]  Rolf Zeller,et al.  Progression of Vertebrate Limb Development Through SHH-Mediated Counteraction of GLI3 , 2002, Science.

[9]  Yina Li,et al.  Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity , 2002, Nature.

[10]  A. Joyner,et al.  Gli1 can rescue the in vivo function of Gli2. , 2001, Development.

[11]  P. Ingham,et al.  Hedgehog signaling in animal development: paradigms and principles. , 2001, Genes & development.

[12]  A. McMahon,et al.  The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides. , 2001, Developmental biology.

[13]  D. Rowitch,et al.  Sonic hedgehog Promotes G1 Cyclin Expression and Sustained Cell Cycle Progression in Mammalian Neuronal Precursors , 2000, Molecular and Cellular Biology.

[14]  M. Nakafuku,et al.  Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3 , 2000, Mechanisms of Development.

[15]  T. Jessell.  Neuronal specification in the spinal cord: inductive signals and transcriptional codes , 2000, Nature Reviews Genetics.

[16]  T. Kornberg,et al.  Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities. , 2000, Development.

[17]  C. Chiang,et al.  Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3 , 2000, Nature Neuroscience.

[18]  A. Joyner,et al.  Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation. , 2000, Development.

[19]  Philip A Beachy,et al.  Hedgehog-Regulated Processing of Gli3 Produces an Anterior/Posterior Repressor Gradient in the Developing Vertebrate Limb , 2000, Cell.

[20]  T. Kornberg,et al.  Ci: a complex transducer of the hedgehog signal. , 1999, Trends in genetics : TIG.

[21]  M. Nakafuku,et al.  Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling. , 1999, Development.

[22]  T. Jessell,et al.  A Sonic Hedgehog–Independent, Retinoid-Activated Pathway of Neurogenesis in the Ventral Spinal Cord , 1999, Cell.

[23]  Konrad Basler,et al.  Hedgehog Controls Limb Development by Regulating the Activities of Distinct Transcriptional Activator and Repressor Forms of Cubitus interruptus , 1999, Cell.

[24]  Yasunori Tanaka,et al.  Sonic Hedgehog-induced Activation of the Gli1Promoter Is Mediated by GLI3* , 1999, The Journal of Biological Chemistry.

[25]  L. Biesecker,et al.  GLI3 mutations in human disorders mimic Drosophila cubitus interruptus protein functions and localization. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[26]  D. Kalderon,et al.  Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator , 1998, Nature.

[27]  A. Joyner,et al.  Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system. , 1998, Development.

[28]  J. Rossant,et al.  Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. , 1998, Development.

[29]  M. Tsai,et al.  Mediation of Sonic hedgehog-induced expression of COUP-TFII by a protein phosphatase. , 1997, Science.

[30]  E. B. Goodwin,et al.  Conservation of the C.elegans tra‐2 3′UTR translational control , 1997, The EMBO journal.

[31]  A. Ruiz i Altaba,et al.  Gli1 is a target of Sonic hedgehog that induces ventral neural tube development. , 1997, Development.

[32]  A. Gurney,et al.  Control of Cell Pattern in the Neural Tube by the Zinc Finger Transcription Factor and Oncogene Gli-1 , 1997, Neuron.

[33]  A. Joyner,et al.  A mouse model of Greig cephalo–polysyndactyly syndrome: the extra–toesJ mutation contains an intragenic deletion of the Gli3 gene , 1993, Nature Genetics.

[34]  K. Kinzler,et al.  GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity , 1990, Molecular and cellular biology.

[35]  A. LaMantia,et al.  High-resolution mapping of the Gli3 mutation Extra-toesJ reveals a 51.5-kb deletion , 2001, Mammalian Genome.