4′-α-C-Branched N,O-nucleosides: synthesis and biological properties

[1]  A. Rescifina,et al.  Enantioselective synthesis of N, O-psiconucleosides , 2003 .

[2]  A. Rescifina,et al.  Enantioselective syntheses and cytotoxicity of N,O-nucleosides. , 2003, Journal of medicinal chemistry.

[3]  Erik De Clercq,et al.  New anti‐HIV agents and targets , 2002, Medicinal research reviews.

[4]  A. Rescifina,et al.  Modified nucleosides. A general and diastereoselective approach to N, O-psiconucleosides , 2002 .

[5]  J. Grassi,et al.  Synthesis of haptens for the development of immunoassays for the monitoring of intracellular anti-HIV nucleosides and nucleotides , 2001 .

[6]  M. Matsuoka,et al.  4′-Ethynyl Nucleoside Analogs: Potent Inhibitors of Multidrug-Resistant Human Immunodeficiency Virus Variants In Vitro , 2001, Antimicrobial Agents and Chemotherapy.

[7]  Erik De Clercq,et al.  New developments in anti-HIV chemotherapy , 2001 .

[8]  S. Shuto,et al.  Nucleosides and nucleotides. 185. Synthesis and biological activities of 4'alpha-C-branched-chain sugar pyrimidine nucleosides. , 1999, Journal of medicinal chemistry.

[9]  S. Grelli,et al.  Identification of nuclei from apoptotic, necrotic, and viable lymphoid cells by using multiparameter flow cytometry. , 1999, Cytometry.

[10]  E. Beers Programmed cell death during plant growth and development , 1997, Cell Death and Differentiation.

[11]  S. Grelli,et al.  Herpes simplex virus 2 causes apoptotic infection in monocytoid cells , 1997, Cell Death and Differentiation.

[12]  M. Fukushima,et al.  Nucleosides and Nucleotides. 158. 1-(3-C-Ethynyl-β-d-ribo-pentofuranosyl)- cytosine, 1-(3-C-Ethynyl-β-d-ribo-pentofuranosyl)uracil, and Their Nucleobase Analogues as New Potential Multifunctional Antitumor Nucleosides with a Broad Spectrum of Activity1 , 1996 .

[13]  E. Santaniello,et al.  Baker’s Yeast Mediated Biohydrogenation of 2-Substituted Allyl Alcohols: Synthesis of Enantiomerically Pure (2S)-3-Benzyloxy-2-methyl-1-propanol , 1996 .

[14]  A. Rescifina,et al.  Modified dideoxynucleosides: Synthesis of 2′-N-alkyl-3′-hydroxyalkyl-1′,2′-isoxazolidinyl thymidine and 5-fluorouridine derivatives , 1996 .

[15]  A. Matsuda,et al.  Nucleosides and nucleotides. 141. Chemical stability of a new antitumor nucleoside, 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine in alkaline medium: formation of 2'-C-cyano-2'-deoxy-1-beta-D-ribo-pentofuranosylcytosine and its antitumor activity. , 1995, Journal of medicinal chemistry.

[16]  Y. Cheng,et al.  Anticancer activity of beta-L-dioxolane-cytidine, a novel nucleoside analogue with the unnatural L configuration. , 1995, Cancer research.

[17]  A. Matsuda,et al.  2′-C-Cyano-2′-deoxy-1-β-D-arabinofuranosylcytosine (CNDAC): A Mechanism-Based DNA-Strand-Breaking Antitumor Nucleoside1 , 1995 .

[18]  W. Hong,et al.  Synthesis and antitumor activity of a series of [2-substituted-4,5-bis(aminomethyl)-1,3-dioxolane]platinum(II) complexes. , 1994, Journal of medicinal chemistry.

[19]  J. G. Cory,et al.  2'-Deoxy-2'-methylene derivatives of adenosine, guanosine, tubercidin, cytidine and uridine as inhibitors of L1210 cell growth in culture. , 1994, Biochemical pharmacology.

[20]  C. Bolm,et al.  Catalyzed Enantioselective Borane Reduction of Ketimine Derivatives , 1994 .

[21]  N. Minakawa,et al.  Nucleosides and nucleotides. 122. 2'-C-cyano-2'-deoxy-1-beta-D-arabinofuranosylcytosine and its derivatives. A new class of nucleoside with a broad antitumor spectrum. , 1993, Journal of medicinal chemistry.

[22]  R. Schinazi,et al.  Deoxycytidine deaminase-resistant stereoisomer is the active form of (+/-)-2',3'-dideoxy-3'-thiacytidine in the inhibition of hepatitis B virus replication. , 1992, The Journal of biological chemistry.

[23]  A. Matsuda,et al.  Antitumor activity of a novel nucleoside, 2'-C-cyano-2'-deoxy-1-beta-D-arabinofuranosylcytosine (CNDAC) against murine and human tumors. , 1992, Cancer letters.

[24]  L. J. Kurz,et al.  4'-Substituted nucleosides as inhibitors of HIV : an unusual oxetane derivative , 1992 .

[25]  K. A. Walker,et al.  Synthesis of 4′-cyanothymidine and analogs as potent inhibitors of HIV. , 1992 .

[26]  D. Stemerick,et al.  Stereospecific method to (E) and (Z) terminal fluoroolefins and its application to the synthesis of 2'-deoxy-2'-fluoromethylenenucleosides as potential inhibitors of ribonucleoside diphosphate reductase , 1991 .

[27]  A. Matsuda,et al.  Nucleosides and nucleotides. 100. 2'-C-cyano-2'-deoxy-1-beta-D-arabinofuranosyl-cytosine (CNDAC): design of a potential mechanism-based DNA-strand-breaking antineoplastic nucleoside. , 1991, Journal of medicinal chemistry.

[28]  Y. Cheng,et al.  Synthesis and anticancer and antiviral activities of various 2'- and 3'-methylidene-substituted nucleoside analogues and crystal structure of 2'-deoxy-2'-methylidenecytidine hydrochloride. , 1991, Journal of medicinal chemistry.

[29]  J. Bollinger,et al.  2'-Deoxy-2'-methylenecytidine and 2'-deoxy-2',2'-difluorocytidine 5'-diphosphates: potent mechanism-based inhibitors of ribonucleotide reductase. , 1991, Journal of medicinal chemistry.

[30]  A. Matsuda,et al.  Antitumor activity of 2'-deoxy-2'-methylidenecytidine, a new 2'-deoxycytidine derivative. , 1991, Cancer research.

[31]  A. Matsuda,et al.  Nucleosides and nucleotides. 97. Synthesis of new broad spectrum antineoplastic nucleosides, 2'-deoxy-2'-methylidenecytidine (DMDC) and its derivatives. , 1991, Journal of medicinal chemistry.

[32]  H. Mitsuya,et al.  Molecular targets for AIDS therapy. , 1990, Science.

[33]  E. Clercq New acquisitions in the development of anti-HIV agents. , 1989 .

[34]  R. Pauwels,et al.  Anti-Hiv-1 Activity of 2′,3′-Dideoxinucleoside Analogues : Structure-Activity Relationship , 1989 .

[35]  A. Matsuda,et al.  Design, synthesis, and antineoplastic activity of 2'-deoxy-2'-methylidenecytidine. , 1988, Journal of medicinal chemistry.

[36]  R. Schinazi,et al.  Synthesis and antiviral activity of various 3'-azido analogues of pyrimidine deoxyribonucleosides against human immunodeficiency virus (HIV-1, HTLV-III/LAV). , 1988, Journal of medicinal chemistry.

[37]  R. Schinazi,et al.  Effect of combinations of acyclovir with vidarabine or its 5'-monophosphate on herpes simplex viruses in cell culture and in mice , 1982, Antimicrobial Agents and Chemotherapy.