Cigarette smoke preferentially induces full length ACE2 expression in differentiated primary human airway cultures but does not alter the efficiency of cellular SARS-CoV-2 infection

[1]  G. Screaton,et al.  Analysis of SARS-CoV-2 in Nasopharyngeal Samples from Patients with COVID-19 Illustrates Population Variation and Diverse Phenotypes, Placing the Growth Properties of Variants of Concern in Context with Other Lineages , 2022, mSphere.

[2]  Frances E. Muldoon,et al.  Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity , 2022, Nature.

[3]  G. Gao,et al.  Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2 , 2022, Cell.

[4]  Benjamin J. Polacco,et al.  Evolution of enhanced innate immune evasion by SARS-CoV-2 , 2021, Nature.

[5]  Fabian J Theis,et al.  Determinants of expression of SARS‐CoV‐2 entry‐related genes in upper and lower airways , 2021, Allergy.

[6]  A. Davenport,et al.  Differential expression in humans of the viral entry receptor ACE2 compared with the short deltaACE2 isoform lacking SARS-CoV-2 binding sites , 2021, Scientific Reports.

[7]  S. Glantz,et al.  Smoking is associated with worse outcomes of COVID-19 particularly among younger adults: a systematic review and meta-analysis , 2021, BMC Public Health.

[8]  P. Lehner,et al.  Topical TMPRSS2 inhibition prevents SARS-CoV-2 infection in differentiated primary human airway cells , 2021, bioRxiv.

[9]  Ruth R. Montgomery,et al.  Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes , 2021, PLoS biology.

[10]  D. Baralle,et al.  A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection , 2021, Nature Genetics.

[11]  T. Spector,et al.  Current smoking and COVID-19 risk: results from a population symptom app in over 2.4 million people , 2021, Thorax.

[12]  K. Plath,et al.  Direct Exposure to SARS-CoV-2 and Cigarette Smoke Increases Infection Severity and Alters the Stem Cell-Derived Airway Repair Response , 2020, Cell Stem Cell.

[13]  G. Nolan,et al.  ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs , 2020, Nature Communications.

[14]  Ho Min Kim,et al.  Three-Dimensional Human Alveolar Stem Cell Culture Models Reveal Infection Response to SARS-CoV-2 , 2020, Cell Stem Cell.

[15]  S. Gamblin,et al.  Tissue-specific and interferon-inducible expression of non-functional ACE2 through endogenous retroelement co-option , 2020, Nature Genetics.

[16]  L. Prokunina-Olsson,et al.  Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length SARS-CoV-2 receptor , 2020, Nature Genetics.

[17]  Esben B. Svenningsen,et al.  SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate , 2020, Nature Communications.

[18]  S. Glantz,et al.  Smoking is associated with worse outcomes of COVID-19 particularly among younger adults: A systematic review and meta-analysis , 2020, medRxiv.

[19]  D. Meyerholz,et al.  Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract , 2020, EBioMedicine.

[20]  Fabian J Theis,et al.  Determinants of SARS-CoV-2 receptor gene expression in upper and lower airways , 2020, medRxiv.

[21]  T. Solomon,et al.  Methods of Inactivation of SARS-CoV-2 for Downstream Biological Assays , 2020, The Journal of infectious diseases.

[22]  M. Chung,et al.  SARS-CoV-2 and ACE2: The biology and clinical data settling the ARB and ACEI controversy , 2020, EBioMedicine.

[23]  K. Plath,et al.  Direct exposure to SARS-CoV-2 and cigarette smoke increases infection severity and alters the stem cell-derived airway repair response , 2020, bioRxiv.

[24]  K. Bhaskaran,et al.  OpenSAFELY: factors associated with COVID-19 death in 17 million patients , 2020, Nature.

[25]  A. Majeed,et al.  Smoking, SARS-CoV-2 and COVID-19: A review of reviews considering implications for public health policy and practice , 2020, Tobacco induced diseases.

[26]  J. Turgeon,et al.  ACE2 as a Therapeutic Target for COVID-19; Its Role in Infectious Processes and Regulation by Modulators of the RAAS System , 2020, Journal of clinical medicine.

[27]  I. Solomon,et al.  In situ detection of SARS-CoV-2 in lungs and airways of patients with COVID-19 , 2020, Modern Pathology.

[28]  G. Joos,et al.  Increased expression of ACE2, the SARS-CoV-2 entry receptor, in alveolar and bronchial epithelium of smokers and COPD subjects , 2020, European Respiratory Journal.

[29]  Lisa E. Gralinski,et al.  SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract , 2020, Cell.

[30]  P. Horby,et al.  Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study , 2020, BMJ.

[31]  D. Sin,et al.  Smoking, ACE-2 and COVID-19: ongoing controversies , 2020, European Respiratory Journal.

[32]  K. Farsalinos,et al.  Editorial: Nicotine and SARS-CoV-2: COVID-19 may be a disease of the nicotinic cholinergic system , 2020, Toxicology Reports.

[33]  R. Vettor,et al.  Reply to: “Current smoking is not associated with COVID-19” , 2020, European Respiratory Journal.

[34]  Patrizia Russo,et al.  COVID-19 and smoking: is nicotine the hidden link? , 2020, European Respiratory Journal.

[35]  Y. Bossé,et al.  Tobacco Smoking Increases the Lung Gene Expression of ACE2, the Receptor of SARS-CoV-2 , 2020, American journal of respiratory and critical care medicine.

[36]  O. Perski,et al.  The association of smoking status with SARS-CoV-2 infection, hospitalisation and mortality from COVID-19: A living rapid evidence review (version 5) , 2020, Qeios.

[37]  D. Meyerholz,et al.  Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract , 2020, bioRxiv.

[38]  O. Tsang,et al.  Comparative tropism, replication kinetics, and cell damage profiling of SARS-CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and laboratory studies of COVID-19: an observational study , 2020, The Lancet Microbe.

[39]  A. Spanevello,et al.  The pivotal link between ACE2 deficiency and SARS-CoV-2 infection , 2020, European Journal of Internal Medicine.

[40]  Martin Stahl,et al.  Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2 , 2020, Cell.

[41]  Jiaofeng Huang,et al.  The impact of COPD and smoking history on the severity of COVID‐19: A systemic review and meta‐analysis , 2020, Journal of medical virology.

[42]  R. Crystal,et al.  Intermittent exposure to whole cigarette smoke alters the differentiation of primary small airway epithelial cells in the air-liquid interface culture , 2020, Scientific Reports.

[43]  K. Yuen,et al.  Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2 , 2020, Cell.

[44]  C. Lindskog,et al.  The protein expression profile of ACE2 in human tissues , 2020, bioRxiv.

[45]  Jason M. Sheltzer,et al.  Cigarette Smoke Exposure and Inflammatory Signaling Increase the Expression of the SARS-CoV-2 Receptor ACE2 in the Respiratory Tract , 2020, bioRxiv.

[46]  Linqi Zhang,et al.  Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor , 2020, Nature.

[47]  D. Sin,et al.  ACE-2 expression in the small airway epithelia of smokers and COPD patients: implications for COVID-19 , 2020, European Respiratory Journal.

[48]  Fabian J Theis,et al.  SARS-CoV-2 Receptor ACE2 is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Enriched in Specific Cell Subsets Across Tissues , 2020, SSRN Electronic Journal.

[49]  Fabian J Theis,et al.  SARS-CoV-2 Entry Genes Are Most Highly Expressed in Nasal Goblet and Ciliated Cells within Human Airways , 2020, Nature Medicine.

[50]  G. Herrler,et al.  SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor , 2020, Cell.

[51]  Wenying Lu,et al.  Smoking Upregulates Angiotensin-Converting Enzyme-2 Receptor: A Potential Adhesion Site for Novel Coronavirus SARS-CoV-2 (Covid-19) , 2020, Journal of clinical medicine.

[52]  T. Thatcher,et al.  Cigarette smoke dampens antiviral signaling in small airway epithelial cells by disrupting TLR3 cleavage. , 2018, American journal of physiology. Lung cellular and molecular physiology.

[53]  R. Hajar Smoking , 2018, Heart views : the official journal of the Gulf Heart Association.

[54]  G. Evan,et al.  SOX2 Drives Bronchial Dysplasia in a Novel Organotypic Model of Early Human Squamous Lung Cancer , 2017, American journal of respiratory and critical care medicine.

[55]  O. Eickelberg,et al.  Cigarette smoke alters primary human bronchial epithelial cell differentiation at the air-liquid interface , 2015, Scientific Reports.

[56]  C. Zhang,et al.  Angiotensin-converting enzyme 2 and angiotensin 1–7: novel therapeutic targets , 2014, Nature Reviews Cardiology.

[57]  A. Guerrero-Plata,et al.  Cigarette smoke suppresses TLR-7 stimulation in response to virus infection in plasmacytoid dendritic cells. , 2011, Toxicology in vitro : an international journal published in association with BIBRA.

[58]  Wei Zhang,et al.  Cigarette smoke extract suppresses the RIG-I-initiated innate immune response to influenza virus in the human lung. , 2011, American journal of physiology. Lung cellular and molecular physiology.

[59]  B. Zuraw,et al.  Cigarette smoke decreases innate responses of epithelial cells to rhinovirus infection. , 2011, American journal of respiratory cell and molecular biology.

[60]  M. Modestou,et al.  Inhibition of IFN-γ-dependent antiviral airway epithelial defense by cigarette smoke , 2010, Respiratory research.

[61]  J. Penninger,et al.  Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis. , 2010, Circulation journal : official journal of the Japanese Circulation Society.

[62]  Ralph S. Baric,et al.  Severe Acute Respiratory Syndrome Coronavirus Infection of Human Ciliated Airway Epithelia: Role of Ciliated Cells in Viral Spread in the Conducting Airways of the Lungs , 2005, Journal of Virology.

[63]  S. Perlman,et al.  ACE2 Receptor Expression and Severe Acute Respiratory Syndrome Coronavirus Infection Depend on Differentiation of Human Airway Epithelia , 2005, Journal of Virology.

[64]  Mark Chappell,et al.  A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury , 2005, Nature Medicine.

[65]  S. Rennard Cigarette smoke in research. , 2004, American journal of respiratory cell and molecular biology.