LC-MS/MS assay coupled with carboxylic acid magnetic bead affinity capture to quantitatively measure cationic host defense peptides (HDPs) in complex matrices with application to preclinical pharmacokinetic studies.

[1]  R. Sashidhar,et al.  Antiaflatoxigenic effects of selected antifungal peptides , 2019, Peptides.

[2]  K. Rajasekaran,et al.  Control of Aspergillus flavus growth and aflatoxin production in transgenic maize kernels expressing a tachyplesin-derived synthetic peptide, AGM182. , 2018, Plant science : an international journal of experimental plant biology.

[3]  L. E. Clemens,et al.  Designed Host Defense Peptides for the Treatment of Bacterial Keratitis , 2017, Investigative ophthalmology & visual science.

[4]  Perry G Wang,et al.  Matrix effects and application of matrix effect factor. , 2017, Bioanalysis.

[5]  M. Roudbary,et al.  Antimicrobial Peptides As Biologic and Immunotherapeutic Agents against Cancer: A Comprehensive Overview , 2017, Front. Immunol..

[6]  A. Gautam,et al.  THPdb: Database of FDA-approved peptide and protein therapeutics , 2017, PloS one.

[7]  Guangshun Wang,et al.  Host defense antimicrobial peptides as antibiotics: design and application strategies. , 2017, Current opinion in chemical biology.

[8]  B. Deslouches,et al.  Antimicrobial peptides with selective antitumor mechanisms: prospect for anticancer applications , 2017, Oncotarget.

[9]  Daria Mochly-Rosen,et al.  Peptidomimetic therapeutics: scientific approaches and opportunities. , 2017, Drug discovery today.

[10]  Erin E. Gill,et al.  The immunology of host defence peptides: beyond antimicrobial activity , 2016, Nature Reviews Immunology.

[11]  Robert E W Hancock,et al.  Host defense peptides: front-line immunomodulators. , 2014, Trends in immunology.

[12]  Hideoki Ogawa,et al.  The innate defense regulator peptides IDR‐HH2, IDR‐1002, and IDR‐1018 modulate human neutrophil functions , 2013, Journal of leukocyte biology.

[13]  Olga M. Pena,et al.  Synthetic Cationic Peptide IDR-1018 Modulates Human Macrophage Differentiation , 2013, PloS one.

[14]  R. Bodnar,et al.  An IP-10 (CXCL10)-Derived Peptide Inhibits Angiogenesis , 2012, PloS one.

[15]  L. Hooper,et al.  Epithelial antimicrobial defence of the skin and intestine , 2012, Nature Reviews Immunology.

[16]  Robert E. W. Hancock,et al.  Modulating immunity as a therapy for bacterial infections , 2012, Nature Reviews Microbiology.

[17]  G. Schneider,et al.  Designing antimicrobial peptides: form follows function , 2011, Nature Reviews Drug Discovery.

[18]  R. Hancock,et al.  Potential of immunomodulatory host defense peptides as novel anti-infectives , 2009, Trends in Biotechnology.

[19]  Y. Michotte,et al.  Validation of bioanalytical LC-MS/MS assays: evaluation of matrix effects. , 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[20]  M. N. Melo,et al.  Antimicrobial peptides: linking partition, activity and high membrane-bound concentrations , 2009, Nature Reviews Microbiology.

[21]  R. Hancock,et al.  Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies , 2006, Nature Biotechnology.

[22]  Kanniah Rajasekaran,et al.  Disease resistance conferred by the expression of a gene encoding a synthetic peptide in transgenic cotton (Gossypium hirsutum L.) plants. , 2005, Plant biotechnology journal.

[23]  C. Hawkey,et al.  Rdp58 Is a Novel and Potentially Effective Oral Therapy for Ulcerative Colitis , 2005, Inflammatory bowel diseases.

[24]  Cleveland,et al.  Transgenic expression of a gene encoding a synthetic antimicrobial peptide results in inhibition of fungal growth in vitro and in planta. , 2000, Plant science : an international journal of experimental plant biology.

[25]  Y. Shai,et al.  Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides. , 1999, Biochimica et biophysica acta.

[26]  Ji Ming Wang,et al.  β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6 , 1999 .

[27]  Robert E W Hancock,et al.  Antimicrobial Peptides: An Introduction. , 2017, Methods in molecular biology.

[28]  J. Jaynes,et al.  Structure/Function Link Between Cytokine Domains and Natural and Designed Lytic Peptides: Medical Promise , 2012 .