Anatase Coating Improves Implant Osseointegration In Vivo

Titanium is the gold standard among materials used for prosthetic devices because of its good mechanical and chemical properties. When exposed to oxygen, titanium becomes an oxide that is biocompatible and able to induce osseointegration. There are three allotropic forms of titanium dioxide: brookite, rutile, and anatase. Anatase can be prepared as a colloidal suspension and then used to coat surfaces. Anatase coating (AC) can potentially have specific biologic effects. We test the effect of AC on bone throughout an in vivo study by using dental implants covered with AC and then inserted in rabbit tibia. The histologic analysis has demonstrated that 1) bone growth is more evident around AC fixtures than in controls and 2) a more mature bone is present in the periimplant AC surface than in controls. Therefore, we have demonstrated that AC enhances implant osseointegration.

[1]  R. Advíncula,et al.  Osteoblast adhesion and matrix mineralization on sol-gel-derived titanium oxide. , 2006, Biomaterials.

[2]  Yongsoo Jeong,et al.  Microstructural characterization of biomedical titanium oxide film fabricated by electrochemical method , 2005 .

[3]  T. Peltola,et al.  TF-XRD examination of surface-reactive TiO2 coatings produced by heat treatment and CO2 laser treatment. , 2005, Biomaterials.

[4]  Yoshiaki Toyama,et al.  Osseointegration of a hydroxyapatite-coated multilayered mesh stem. , 2004, Biomaterials.

[5]  Jai-Young Koak,et al.  Improved biological performance of Ti implants due to surface modification by micro-arc oxidation. , 2004, Biomaterials.

[6]  Yongnian Yan,et al.  Preparation of porous anatase titania film , 2004 .

[7]  S. Volinia,et al.  Analysis of MG63 osteoblastic-cell response to a new nanoporous implant surface by means of a microarray technology. , 2004, Clinical oral implants research.

[8]  Niklaus P Lang,et al.  Critical review of immediate implant loading. , 2003, Clinical oral implants research.

[9]  T. Troczynski,et al.  Apatite formation on TiO2 anatase microspheres , 2003 .

[10]  M. Maitz,et al.  Structure and properties of titanium oxide layers prepared by metal plasma immersion ion implantation and deposition , 2003 .

[11]  Yong Han,et al.  Structure and in vitro bioactivity of titania-based films by micro-arc oxidation , 2003 .

[12]  C. Lohmann,et al.  Autologous osteoblasts enhance osseointegration of porous titanium implants , 2003, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[13]  R. Thull,.  Physicochemical principles of tissue material interactions. , 2002, Biomolecular engineering.

[14]  Ann Wennerberg,et al.  Resonance frequency and removal torque analysis of implants with turned and anodized surface oxides. , 2002, Clinical oral implants research.

[15]  Yong Han,et al.  Porous nanocrystalline titania films by plasma electrolytic oxidation , 2002 .

[16]  K E Tanner,et al.  Titanium in Medicine , 2002 .

[17]  L. Hanley,et al.  Preparation and analysis of macroporous TiO2 films on Ti surfaces for bone-tissue implants. , 2001, Journal of biomedical materials research.

[18]  H. Ishizawa,et al.  Hydrothermal precipitation of hydroxyapatite on anodic titanium oxide films containing Ca and P , 1999 .

[19]  S. Santavirta,et al.  Potential of coatings in total hip replacement. , 2005, Clinical orthopaedics and related research.