EFFECT OF MELATONIN ON SERUM GLUCOSE AND BODY WEIGHT IN STREPTOZOTOCIN INDUCED DIABETES IN ALBINO RATS.

BACKGROUND It has been demonstrated in experimental animal models that oxidative stress causes persistent and chronic hyperglycaemia, causing reduction in antioxidant defence system, ultimately leading to accumulation of free radicals. This study, was performed to observe the effect of melatonin on serum glucose and body weights in streptozotocin induced diabetes in albino rats. METHODS Forty healthy adult male albino rats were included in the study and divided equally into 4 groups for 6 weeks. Group-A was taken as control. Group-B received streptozotocin I/P in a dose of 37 mg/kg body weight. Group-C received 10 mg/100 ml melatonin in drinking water and Group-D received only melatonin. RESULTS Streptozotocin significantly increased serum glucose and decreased weight in group B animals, whereas in group C, melatonin significantly restored serum glucose but could not restore the body weights reduced by streptozotocin. There was a significant reduction in body weight in melatonin treated group D animals. CONCLUSION Melatonin decreases oxidative stress and hyperglycemia, but cannot restore the body weight reduced by streptozotocin. In fact, it further reduces body weight both in diabetic and normal state.

[1]  H. Raza,et al.  Streptozotocin-Induced Cytotoxicity, Oxidative Stress and Mitochondrial Dysfunction in Human Hepatoma HepG2 Cells , 2012, International journal of molecular sciences.

[2]  A. Yashin,et al.  Melatonin increases both life span and tumor incidence in female CBA mice. , 2001, The journals of gerontology. Series A, Biological sciences and medical sciences.

[3]  O. Naseer,et al.  Short‐term effects of streptozotocin‐induced diabetes on the electrocardiogram, physical activity and body temperature in rats , 2005, Experimental physiology.

[4]  M. Lamy-Freund,et al.  Permeability of pure lipid bilayers to melatonin , 1995, Journal of pineal research.

[5]  A. Bolzán,et al.  Genotoxicity of streptozotocin. , 2002, Mutation research.

[6]  N. Aksoy,et al.  Melatonin inhibits lipid peroxidation and stimulates the antioxidant status of diabetic rats , 2001, Journal of pineal research.

[7]  A. Alonso,et al.  Insulin sensitivity in streptozotocin‐induced diabetic rats treated with different doses of 17β‐oestradiol or progesterone , 2007, Experimental physiology.

[8]  V. Bhor,et al.  Oxidative damage and altered antioxidant enzyme activities in the small intestine of streptozotocin-induced diabetic rats. , 2004, The international journal of biochemistry & cell biology.

[9]  S. B. Peres,et al.  Melatonin enhances leptin expression by rat adipocytes in the presence of insulin. , 2005, American journal of physiology. Endocrinology and metabolism.

[10]  H. Canatan,et al.  Comparative analysis of the protective effects of melatonin and vitamin E on streptozocin‐induced diabetes mellitus , 2002, Journal of pineal research.

[11]  I. Bazwinsky,et al.  Increased melatonin synthesis in pineal glands of rats in streptozotocin induced type 1 diabetes , 2008, Journal of pineal research.

[12]  A. Meki,et al.  Oxidative stress in streptozotocin-induced diabetic rats: effects of garlic oil and melatonin. , 2003, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.

[13]  L. Fuentes-Broto,et al.  Significance and application of melatonin in the regulation of brown adipose tissue metabolism: relation to human obesity , 2011, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[14]  A. Matsumoto,et al.  Daily Melatonin Administration to Middle-Aged Male Rats Suppresses Body Weight, Intraabdominal Adiposity, and Plasma Leptin and Insulin Independent of Food Intake and Total Body Fat1. , 2000, Endocrinology.

[15]  S. Naqvi,et al.  Altered Liver Morphology and Enzymes in Streptozotocin Induced Diabetic Rats , 2009 .

[16]  A. Jagielski,et al.  Melatonin‐induced modulation of glucose metabolism in primary cultures of rabbit kidney‐cortex tubules , 2005, Journal of pineal research.

[17]  S. Abdeen,et al.  Effect of green tea on kidney tubules of diabetic rats , 2008, British Journal of Nutrition.

[18]  G. Jerums,et al.  Prevention of albuminuria by aminoguanidine or ramipril in streptozotocin-induced diabetic rats is associated with the normalization of glomerular protein kinase C. , 2000, Diabetes.

[19]  C. K. Song,et al.  Seasonal Changes in Adiposity: the Roles of the Photoperiod, Melatonin and Other Hormones, and Sympathetic Nervous System , 2002, Experimental biology and medicine.

[20]  N. Vaziri,et al.  Melatonin ameliorates oxidative stress, inflammation, proteinuria, and progression of renal damage in rats with renal mass reduction. , 2008, American journal of physiology. Renal physiology.