Surface-enhanced Raman scattering (SERS) for probing internal cellular structure and dynamics

Surface-enhanced Raman scattering (SERS) provides vibrational information about molecules that are located within several nanometers of the surface of a metallic nanoparticle. This review describes the various challenges and successes of applying SERS inside living cells in order to gain information about the internal structure and dynamic processes occurring in the intracellular matrix. In particular, the challenges associated with the introduction of metal nanoparticles into cells are described, as well as the complexity of interpreting SERS spectra from within complex biological environments. Strategies for understanding and improving the specificity of SERS in vivo are also presented.

[1]  A. Kudelski,et al.  Fluctuations of surface-enhanced Raman spectra of CO adsorbed on gold substrates , 2004 .

[2]  George C. Schatz,et al.  Electromagnetic mechanism of SERS , 2006 .

[3]  Olga Lyandres,et al.  Rapid detection of an anthrax biomarker by surface-enhanced Raman spectroscopy. , 2005, Journal of the American Chemical Society.

[4]  R. V. Omkumar,et al.  Growth of gold nanoparticles in human cells. , 2005, Langmuir : the ACS journal of surfaces and colloids.

[5]  Bruce Ravel,et al.  Mechanisms of gold bioaccumulation by filamentous cyanobacteria from gold(III)-chloride complex. , 2006, Environmental science & technology.

[6]  M. Albrecht,et al.  Anomalously intense Raman spectra of pyridine at a silver electrode , 1977 .

[7]  Alyson V. Whitney,et al.  Identification and Characterization of Artists' Red Dyes and Their Mixtures by Surface-Enhanced Raman Spectroscopy , 2007, Applied spectroscopy.

[8]  Bryce J Marquis,et al.  Dynamic measurement of altered chemical messenger secretion after cellular uptake of nanoparticles using carbon-fiber microelectrode amperometry. , 2008, Analytical chemistry.

[9]  Arezou A Ghazani,et al.  Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells. , 2006, Nano letters.

[10]  C. Mirkin,et al.  Nanoparticles with Raman spectroscopic fingerprints for DNA and RNA detection. , 2002, Science.

[11]  R. Álvarez-Puebla,et al.  SERS detection of environmental pollutants in humic acid-gold nanoparticle composite materials. , 2007, The Analyst.

[12]  H. Beier,et al.  Nanofluidic biosensing for beta-amyloid detection using surface enhanced Raman spectroscopy. , 2008, Nano letters.

[13]  Huabing Yin,et al.  A microfluidic‐based system for analysis of single cells based on Ca2+ flux , 2006, Electrophoresis.

[14]  K. Kneipp,et al.  Surface-enhanced Raman scattering in local optical fields of silver and gold nanoaggregates-from single-molecule Raman spectroscopy to ultrasensitive probing in live cells. , 2006, Accounts of chemical research.

[15]  M. Moskovits.  Surface‐enhanced Raman spectroscopy: a brief retrospective , 2005 .

[16]  Naomi J Halas,et al.  Aromatic amino acids providing characteristic motifs in the Raman and SERS spectroscopy of peptides. , 2008, The journal of physical chemistry. B.

[17]  Hong-Wu Tang,et al.  Chemical Probing of Single Cancer Cells with Gold Nanoaggregates by Surface-Enhanced Raman Scattering , 2008, Applied spectroscopy.

[18]  Yanli Liu,et al.  Cellular trajectories of peptide-modified gold particle complexes: comparison of nuclear localization signals and peptide transduction domains. , 2004, Bioconjugate chemistry.

[19]  Chad A Mirkin,et al.  Raman dye-labeled nanoparticle probes for proteins. , 2003, Journal of the American Chemical Society.

[20]  Peidong Yang,et al.  Surface-enhanced Raman spectroscopy for trace arsenic detection in contaminated water. , 2008, Angewandte Chemie.

[21]  Janina Kneipp,et al.  In vivo molecular probing of cellular compartments with gold nanoparticles and nanoaggregates. , 2006, Nano letters.

[22]  D. A. Stuart,et al.  Surface-enhanced Raman spectroscopy of half-mustard agent. , 2006, The Analyst.

[23]  Martin Moskovits,et al.  Surface-enhanced Raman spectroscopy for DNA detection by nanoparticle assembly onto smooth metal films. , 2007, Journal of the American Chemical Society.

[24]  R. Tsien,et al.  Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein , 2004, Nature Biotechnology.

[25]  Xiao-Hong Nancy Xu,et al.  Real-time probing of membrane transport in living microbial cells using single nanoparticle optics and living cell imaging. , 2004, Biochemistry.

[26]  Richard P Van Duyne,et al.  Lactate and sequential lactate-glucose sensing using surface-enhanced Raman spectroscopy. , 2007, Analytical chemistry.

[27]  Hong-Wu Tang,et al.  Probing intrinsic and extrinsic components in single osteosarcoma cells by near-infrared surface-enhanced Raman scattering. , 2007, Analytical chemistry.

[28]  N. Pieczonka,et al.  Chemically selective sensing through layer-by-layer incorporation of biorecognition into thin film substrates for surface-enhanced resonance Raman scattering. , 2006, Journal of the American Chemical Society.

[29]  Michael S. Feld,et al.  Surface-Enhanced Raman Spectroscopy in Single Living Cells Using Gold Nanoparticles , 2002 .

[30]  Y. Ozaki,et al.  Removal of Interference Signals Due to Water from in vivo Near-Infrared (NIR) Spectra of Blood Glucose by Region Orthogonal Signal Correction (ROSC) , 2004, Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.

[31]  Cees Otto,et al.  Noninvasive imaging of protein metabolic labeling in single human cells using stable isotopes and Raman microscopy. , 2008, Analytical chemistry.

[32]  R. V. Van Duyne,et al.  Localized surface plasmon resonance spectroscopy and sensing. , 2007, Annual review of physical chemistry.

[33]  Bayden R. Wood,et al.  Raman excitation wavelength investigation of single red blood cells in vivo , 2002 .

[34]  R. V. Van Duyne,et al.  A frequency domain existence proof of single-molecule surface-enhanced Raman spectroscopy. , 2007, Journal of the American Chemical Society.

[35]  N. Shah,et al.  Surface-enhanced Raman spectroscopy. , 2008, Annual review of analytical chemistry.

[36]  Priyabrata Mukherjee,et al.  The use of microorganisms for the formation of metal nanoparticles and their application , 2005, Applied Microbiology and Biotechnology.

[37]  Martin Moskovits,et al.  A heterogeneous PNA-based SERS method for DNA detection. , 2007, Journal of the American Chemical Society.

[38]  Cees Otto,et al.  Hybrid confocal Raman fluorescence microscopy on single cells using semiconductor quantum dots. , 2007, Nano letters.

[39]  Sudhakar R. Sainkar,et al.  Fungus-mediated synthesis of silver nanoparticles and their immobilization in the mycelial matrix: a novel biological approach to nanoparticle synthesis , 2001 .

[40]  H. Hamaguchi,et al.  Behaviors of the “Raman Spectroscopic Signature of Life” in Single Living Fission Yeast Cells under Different Nutrient, Stress, and Atmospheric Conditions , 2007, Applied spectroscopy.

[41]  Louis E. Brus,et al.  Surface Enhanced Raman Spectroscopy of Individual Rhodamine 6G Molecules on Large Ag Nanocrystals , 1999 .

[42]  R. Tsien,et al.  green fluorescent protein , 2020, Catalysis from A to Z.

[43]  Ximei Qian,et al.  Surface-enhanced Raman nanoparticle beacons based on bioconjugated gold nanocrystals and long range plasmonic coupling. , 2008, Journal of the American Chemical Society.

[44]  S. Aștilean,et al.  Bridging biomolecules with nanoparticles: surface‐enhanced Raman scattering from colon carcinoma and normal tissue , 2008 .

[45]  R. L. Jones,et al.  Unique cellular interaction of silver nanoparticles: size-dependent generation of reactive oxygen species. , 2008, The journal of physical chemistry. B.

[46]  Olga Lyandres,et al.  Real-time glucose sensing by surface-enhanced Raman spectroscopy in bovine plasma facilitated by a mixed decanethiol/mercaptohexanol partition layer. , 2005, Analytical chemistry.

[47]  Y. Ozaki,et al.  Surface-Enhanced Raman Spectroscopy , 2005 .

[48]  Sophia V. Kyriacou,et al.  Using nanoparticle optics assay for direct observation of the function of antimicrobial agents in single live bacterial cells. , 2004, Biochemistry.

[49]  M. Kowshik,et al.  Extracellular synthesis of silver nanoparticles by a silver-tolerant yeast strain MKY3 , 2002 .

[50]  Ken-ichi Yoshida,et al.  Surface enhanced Raman scattering analyses of individual silver nanoaggregates on living single yeast cell wall , 2008 .

[51]  R. Kumar,et al.  Extracellular Synthesis of Gold Nanoparticles by the Fungus Fusarium oxysporum , 2002, Chembiochem : a European journal of chemical biology.

[52]  Alaaldin M. Alkilany,et al.  Gold nanoparticles in biology: beyond toxicity to cellular imaging. , 2008, Accounts of chemical research.

[53]  G. Schatz,et al.  Electromagnetic fields around silver nanoparticles and dimers. , 2004, The Journal of chemical physics.

[54]  J. Irudayaraj,et al.  Intracellular quantification by surface enhanced Raman spectroscopy , 2008 .

[55]  Martin Moskovits,et al.  Detection of sequence-specific protein-DNA interactions via surface enhanced resonance Raman scattering. , 2007, Journal of the American Chemical Society.

[56]  Pablo G. Etchegoin,et al.  Surface Enhanced Raman Scattering Enhancement Factors: A Comprehensive Study , 2007 .

[57]  Huabing Yin,et al.  Characterization of cellular chemical dynamics using combined microfluidic and Raman techniques , 2007, Analytical and bioanalytical chemistry.

[58]  H. Bohr,et al.  Single-Molecule SERS Spectroscopy , 2006 .

[59]  David Schneider,et al.  Cytotoxicity of metal and semiconductor nanoparticles indicated by cellular micromotility. , 2009, ACS nano.

[60]  Jun Chen,et al.  Direct Measurement of Sizes and Dynamics of Single Living Membrane Transporters Using Nanooptics , 2002 .

[61]  Thomas Huser,et al.  Intracellular pH sensors based on surface-enhanced raman scattering. , 2004, Analytical chemistry.

[62]  K. Kneipp,et al.  One- and two-photon excited optical ph probing for cells using surface-enhanced Raman and hyper-Raman nanosensors. , 2007, Nano letters.

[63]  Robert E Campbell,et al.  New biarsenical ligands and tetracysteine motifs for protein labeling in vitro and in vivo: synthesis and biological applications. , 2002, Journal of the American Chemical Society.

[64]  K. Kneipp,et al.  Optical probes for biological applications based on surface-enhanced Raman scattering from indocyanine green on gold nanoparticles. , 2005, Analytical chemistry.

[65]  Martin Moskovits,et al.  Label-Free SERS Detection of Small Proteins Modified to Act as Bifunctional Linkers. , 2008, The journal of physical chemistry. C, Nanomaterials and interfaces.

[66]  R. Tsien,et al.  The Fluorescent Toolbox for Assessing Protein Location and Function , 2006, Science.

[67]  M. Manfait,et al.  Selective analysis of antitumor drug interaction with living cancer cells as probed by surface-enhanced Raman spectroscopy , 2004, European Biophysics Journal.

[68]  Pavel Matousek,et al.  Raman spectroscopy of street samples of cocaine obtained using Kerr gated fluorescence rejection. , 2004, The Analyst.

[69]  R. Gillies,et al.  Simultaneous measurement of intracellular pH and Ca2+ using the fluorescence of SNARF-1 and fura-2. , 1991, The American journal of physiology.

[70]  Joseph Irudayaraj,et al.  Intracellularly grown gold nanoparticles as potential surface-enhanced Raman scattering probes. , 2007, Journal of biomedical optics.

[71]  Andreas Otto,et al.  The ‘chemical’ (electronic) contribution to surface‐enhanced Raman scattering , 2005 .

[72]  J. Lloyd,et al.  Surface-enhanced Raman scattering from intracellular and extracellular bacterial locations. , 2008, Analytical chemistry.

[73]  E. Wang,et al.  Surface enhanced Raman scattering of brilliant green on Ag nanoparticles and applications in living cells as optical probes , 2007 .

[74]  George C Schatz,et al.  Localized surface plasmon resonance nanosensor: a high-resolution distance-dependence study using atomic layer deposition. , 2005, The journal of physical chemistry. B.

[75]  D. L. Jeanmaire,et al.  Surface raman spectroelectrochemistry: Part I. Heterocyclic, aromatic, and aliphatic amines adsorbed on the anodized silver electrode , 1977 .