Chitosan-Based Quartz Crystal Microbalance for Alcohol Sensing

Short-chain alcohols are a group of volatile organic compounds (VOCs) that are often found in workplaces and laboratories, as well as medical, pharmaceutical, and food industries. Real-time monitoring of alcohol vapors is essential because exposure to alcohol vapors with concentrations of 0.15–0.30 mg·L−1 may be harmful to human health. This study aims to improve the detection capabilities of quartz crystal microbalance (QCM)-based sensors for the analysis of alcohol vapors. The active layer of chitosan was immobilized onto the QCM substrate through a self-assembled monolayer of L-cysteine using glutaraldehyde as a cross-linking agent. Before alcohol analysis, the QCM sensing chip was exposed to humidity because water vapor significantly interferes with QCM gas sensing. The prepared QCM sensor chip was tested for the detection of four different alcohols: n-propanol, ethanol, isoamyl alcohol, and n-amyl alcohol. For comparison, a non-alcohol of acetone was also tested. The prepared QCM sensing chip is selective to alcohols because of hydrogen bond formation between the hydroxyl groups of chitosan and the analyte. The highest response was achieved when the QCM sensing chip was exposed to n-amyl alcohol vapor, with a sensitivity of about 4.4 Hz·mg−1·L. Generally, the sensitivity of the QCM sensing chip is dependent on the molecular weight of alcohol. Moreover, the developed QCM sensing chips are stable after 10 days of repeated measurements, with a rapid response time of only 26 s. The QCM sensing chip provides an alternative method to established analytical methods such as gas chromatography for the detection of short-chain alcohol vapors.

[1]  K. Triyana,et al.  Swelling Behavior in Solvent Vapor Sensing based on Quartz Crystal Microbalance (QCM) Coated Polyacrylonitrile (PAN) Nanofiber , 2018 .

[2]  Jinghong Li,et al.  Interfacial design and functionization on metal electrodes through self-assembled monolayers , 2006 .

[3]  J. D. Winefordner,et al.  Limit of detection. A closer look at the IUPAC definition , 1983 .

[4]  Horn-Jiunn Sheen,et al.  A vapor response mechanism study of surface-modified single-walled carbon nanotubes coated chemiresistors and quartz crystal microbalance sensor arrays. , 2015, Talanta.

[5]  Mehmet Lütfi Yola,et al.  Selective QCM sensor based on atrazine imprinted polymer: Its application to wastewater sample , 2015 .

[6]  Luyu Wang,et al.  Superhydrophilic ZnO nanoneedle array: Controllable in situ growth on QCM transducer and enhanced humidity sensing properties and mechanism , 2018, Sensors and Actuators B: Chemical.

[7]  Kuwat Triyana,et al.  Quartz crystal microbalance coated by PAN nanofibers and PEDOT:PSS for humidity sensor , 2017, 2017 International Seminar on Sensors, Instrumentation, Measurement and Metrology (ISSIMM).

[8]  I. Vieira,et al.  Bean sprout peroxidase biosensor based on l-cysteine self-assembled monolayer for the determination of dopamine , 2008 .

[9]  Kuwat Triyana,et al.  Polyacrylonitrile Nanofiber-Based Quartz Crystal Microbalance for Sensitive Detection of Safrole , 2018, Sensors.

[10]  K. Triyana,et al.  Polyacrylonitrile nanofiber as polar solvent N,N-dimethyl formamide sensor based on quartz crystal microbalance technique , 2018 .

[11]  P. Guyot-Sionnest,et al.  Atomic Layer Deposition of ZnO in Quantum Dot Thin Films , 2009 .

[12]  Guang Li,et al.  Enhanced Dibutyl Phthalate Sensing Performance of a Quartz Crystal Microbalance Coated with Au-Decorated ZnO Porous Microspheres , 2015, Sensors.

[13]  Nagy L. Torad,et al.  Alcohol vapours sensor based on thin polyaniline salt film and quartz crystal microbalance. , 2009, Talanta.

[14]  Xing Meng,et al.  Single‐Crystal‐to‐Single‐Crystal Transformation of a Europium(III) Metal–Organic Framework Producing a Multi‐responsive Luminescent Sensor , 2014 .

[15]  Kuwat Triyana,et al.  Solvent vapor treatment improves mechanical strength of electrospun polyvinyl alcohol nanofibers , 2018, Heliyon.

[16]  Luyu Wang,et al.  High performance formaldehyde detection based on a novel copper (II) complex functionalized QCM gas sensor , 2017 .

[17]  N. Salahuddin,et al.  Chitosan/polyaniline nanofibers coating on the quartz crystal microbalance electrode for gas sensing , 2014 .

[18]  Hua Bai,et al.  Gas Sensors Based on Conducting Polymers , 2007, Sensors (Basel, Switzerland).

[19]  Jacob Fraden,et al.  Handbook of modern sensors , 1997 .

[20]  N. Salahuddin,et al.  Detection of some volatile organic compounds with chitosan-coated quartz crystal microbalance , 2014 .

[21]  Jian Gong,et al.  Fabrication and characterization of poly (vinyl alcohol)/chitosan blend nanofibers produced by electrospinning method , 2007 .

[22]  G. Sauerbrey Verwendung von Schwingquarzen zur Wägung dünner Schichten und zur Mikrowägung , 1959 .

[23]  Kuwat Triyana,et al.  Electrical Conductivity Improvement of Polyvinyl Alcohol Nanofiber by Solvent Vapour Treatment , 2016 .

[24]  Shu’ni Li,et al.  Nonlinear Optical Rod Indium-Imidazoledicarboxylate Framework as Room-Temperature Gas Sensor for Butanol Isomers , 2017 .

[25]  A. Tonkoshkur,et al.  Gas sensitivity of ZnO-based ceramics to vapors of saturated monohydric alcohols , 2013 .

[26]  T. Thundat,et al.  Ultrasensitive Detection of Cu2+ Using a Microcantilever Sensor Modified with L-Cysteine Self-Assembled Monolayer , 2017, Applied Biochemistry and Biotechnology.