Reference bias in the Illumina Isaac aligner

Alex J. Cornish *, Daniel Chubb *, Anna Frangou, Phuc H. Hoang, Martin Kaiser, David C. Wedge and Richard S. Houlston 1 Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SM2 5NG 2, UK, Nuffield Department of Medicine, Big Data Institute University of Oxford, OX3 7LF 3, UK, Molecular Diagnostics Theme, Oxford NIHR Biomedical Research Centre, Oxford, OX3 7LF 3, UK, Division of Molecular Pathology, The Institute of Cancer Research, London SM2 5NG 5, UK and Manchester Cancer Research Centre, University of Manchester, M20 4GJ, UK

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