Systematic Reviews of Genetic Association Studies

Gurdeep S. Sagoo and colleagues describe key components of the methodology for undertaking systematic reviews and meta-analyses of genetic association studies.

[1]  Nikolaos A Patsopoulos,et al.  Bmc Medical Research Methodology Open Access Reporting of Human Genome Epidemiology (huge) Association Studies: an Empirical Assessment , 2022 .

[2]  Siobhan M. Dolan,et al.  Assessment of cumulative evidence on genetic associations: interim guidelines. , 2008, International journal of epidemiology.

[3]  I. Olkin,et al.  Meta-analysis of observational studies in epidemiology - A proposal for reporting , 2000 .

[4]  D. Blacker,et al.  Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database , 2007, Nature Genetics.

[5]  J. Ioannidis,et al.  Replication validity of genetic association studies , 2001, Nature Genetics.

[6]  Julian PT Higgins,et al.  Bmc Medical Research Methodology Open Access Online Genetic Databases Informing Human Genome Epidemiology , 2007 .

[7]  R. Hanka The Handbook of Research Synthesis , 1994 .

[8]  M. Clarke,et al.  Handsearching versus electronic searching to identify reports of randomized trials. , 2002, The Cochrane database of systematic reviews.

[9]  Thomas A Trikalinos,et al.  Early extreme contradictory estimates may appear in published research: the Proteus phenomenon in molecular genetics research and randomized trials. , 2005, Journal of clinical epidemiology.

[10]  J. Higgins,et al.  Joint effects of the N-acetyltransferase 1 and 2 (NAT1 and NAT2) genes and smoking on bladder carcinogenesis: a literature-based systematic HuGE review and evidence synthesis. , 2007, American journal of epidemiology.

[11]  J. Ioannidis,et al.  Bayesian meta‐analysis and meta‐regression for gene–disease associations and deviations from Hardy–Weinberg equilibrium , 2007, Statistics in medicine.

[12]  J. Thompson,et al.  The choice of a genetic model in the meta-analysis of molecular association studies. , 2005, International journal of epidemiology.

[13]  J. Thompson,et al.  How should we use information about HWE in the meta-analyses of genetic association studies? , 2008, International journal of epidemiology.

[14]  J. Ioannidis,et al.  Establishment of genetic associations for complex diseases is independent of early study findings , 2004, European Journal of Human Genetics.

[15]  J. Ioannidis,et al.  Relative Citation Impact of Various Study Designs in the Health Sciences , 2005, JAMA.

[16]  L. Hedges,et al.  The Handbook of Research Synthesis , 1995 .

[17]  M. McCarthy,et al.  Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes , 2008, Nature Genetics.

[18]  Jonathan Marchini,et al.  Comparing algorithms for genotype imputation. , 2008, American journal of human genetics.

[19]  John P A Ioannidis,et al.  Genetic associations: false or true? , 2003, Trends in molecular medicine.

[20]  John P A Ioannidis,et al.  Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database , 2008, Nature Genetics.

[21]  C. Weinberg,et al.  Reporting, appraising, and integrating data on genotype prevalence and gene-disease associations. , 2002, American journal of epidemiology.

[22]  I. Chalmers The Cochrane Collaboration: Preparing, Maintaining, and Disseminating Systematic Reviews of the Effects of Health Care , 1993, Annals of the New York Academy of Sciences.

[23]  J. Higgins,et al.  Meta‐analysis of genetic association studies under different inheritance models using data reported as merged genotypes , 2008, Statistics in medicine.

[24]  Paolo Vineis,et al.  A road map for efficient and reliable human genome epidemiology , 2006, Nature Genetics.

[25]  D. Altman,et al.  Measuring inconsistency in meta-analyses , 2003, BMJ : British Medical Journal.

[26]  D. Clayton,et al.  Population structure, differential bias and genomic control in a large-scale, case-control association study , 2005, Nature Genetics.

[27]  Claudio J. Verzilli,et al.  Bayesian meta-analysis of genetic association studies with different sets of markers. , 2007, American journal of human genetics.

[28]  Douglas G Altman,et al.  Statistical methods for assessing the influence of study characteristics on treatment effects in ‘meta‐epidemiological’ research , 2002, Statistics in medicine.

[29]  Julian P T Higgins,et al.  Controlling the risk of spurious findings from meta‐regression , 2004, Statistics in medicine.

[30]  John P A Ioannidis,et al.  On the synthesis and interpretation of consistent but weak gene-disease associations in the era of genome-wide association studies. , 2007, International journal of epidemiology.

[31]  Thomas A Trikalinos,et al.  Genetic associations in large versus small studies: an empirical assessment , 2003, The Lancet.

[32]  M. S. Patel,et al.  An introduction to meta-analysis. , 1989, Health Policy.

[33]  J R Teagarden,et al.  Meta‐Analysis: Whither Narrative Review? , 1989, Pharmacotherapy.

[34]  I. Olkin,et al.  Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement , 1999, The Lancet.

[35]  John P. A. Ioannidis,et al.  Methods for meta-analysis in genetic association studies: a review of their potential and pitfalls , 2008, Human Genetics.

[36]  Julian P T Higgins,et al.  Obstacles and opportunities in meta-analysis of genetic association studies , 2005, Genetics in Medicine.

[37]  M. Khoury,et al.  The Human Genome Epidemiology Network. , 1998, American journal of epidemiology.