Progranulin Stimulates the In Vitro Maturation of Pro-Cathepsin D at Acidic pH.

[1]  C. Haass,et al.  Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice , 2018, Molecular Neurodegeneration.

[2]  D. Krainc,et al.  Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients , 2017, Human molecular genetics.

[3]  Tuancheng Feng,et al.  Regulation of cathepsin D activity by the FTLD protein progranulin , 2017, Acta Neuropathologica.

[4]  W. Robberecht,et al.  Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo , 2017, Human molecular genetics.

[5]  Param Priya Singh,et al.  Progranulin, lysosomal regulation and neurodegenerative disease , 2017, Nature Reviews Neuroscience.

[6]  Walter G. Park,et al.  Global Protease Activity Profiling Provides Differential Diagnosis of Pancreatic Cysts , 2017, Clinical Cancer Research.

[7]  Susan L Cotman,et al.  Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis , 2017, Science Translational Medicine.

[8]  T. Beach,et al.  Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes , 2017, Human molecular genetics.

[9]  V. Turk,et al.  Lysosomal cathepsins and their regulation in aging and neurodegeneration , 2016, Ageing Research Reviews.

[10]  Tanya M. Teslovich,et al.  Prosaposin is a regulator of progranulin levels and oligomerization , 2016, Nature Communications.

[11]  Ying Sun,et al.  Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin , 2015, The Journal of cell biology.

[12]  Robert V Farese,et al.  Progranulin Protects against Amyloid β Deposition and Toxicity in Alzheimer’s Disease Mouse Models , 2014, Nature Medicine.

[13]  D. Kay,et al.  Progranulin Gene Delivery Protects Dopaminergic Neurons in a Mouse Model of Parkinson’s Disease , 2014, PloS one.

[14]  E. Kremmer,et al.  Common pathobiochemical hallmarks of progranulin-associated frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis , 2014, Acta Neuropathologica.

[15]  S. Pereson,et al.  Cellular ageing, increased mortality and FTLD‐TDP‐associated neuropathology in progranulin knockout mice , 2012, The Journal of pathology.

[16]  C. Sephton,et al.  Progranulin: A Proteolytically Processed Protein at the Crossroads of Inflammation and Neurodegeneration* , 2012, The Journal of Biological Chemistry.

[17]  Katherine R. Smith,et al.  Strikingly different clinicopathological phenotypes determined by progranulin-mutation dosage. , 2012, American journal of human genetics.

[18]  L. Raymond,et al.  Synaptic dysfunction in progranulin-deficient mice , 2012, Neurobiology of Disease.

[19]  Andrea Ballabio,et al.  TFEB Links Autophagy to Lysosomal Biogenesis , 2011, Science.

[20]  L. Petrucelli,et al.  Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging. , 2010, The American journal of pathology.

[21]  A. Bateman,et al.  The granulin gene family: from cancer to dementia , 2009, BioEssays : news and reviews in molecular, cellular and developmental biology.

[22]  A. Ballabio,et al.  A Gene Network Regulating Lysosomal Biogenesis and Function , 2009, Science.

[23]  F. Lovat,et al.  Proepithelin regulates prostate cancer cell biology by promoting cell growth, migration, and anchorage-independent growth. , 2009, The American journal of pathology.

[24]  H. Kalbacher,et al.  Cathepsin D: a cellular roadmap. , 2008, Biochemical and biophysical research communications.

[25]  Martin Fusek,et al.  Cathepsin D--many functions of one aspartic protease. , 2008, Critical reviews in oncology/hematology.

[26]  F. Ni,et al.  Structure dissection of human progranulin identifies well‐folded granulin/epithelin modules with unique functional activities , 2008, Protein science : a publication of the Protein Society.

[27]  J. Ježek,et al.  Cathepsin D propeptide: mechanism and regulation of its interaction with the catalytic core. , 2006, Biochemistry.

[28]  C. van Broeckhoven,et al.  Progranulin mutations in ubiquitin-positive frontotemporal dementia linked to chromosome 17q21. , 2006, Current Alzheimer research.

[29]  V. Vetvicka,et al.  Role of activation peptide of procathepsin D in proliferation and invasion of lung cancer cells. , 2006, Anticancer research.

[30]  S. Melquist,et al.  Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17 , 2006, Nature.

[31]  K. Blennow,et al.  The Cathepsin D rs17571 polymorphism: effects on CSF tau concentrations in Alzheimer disease , 2006, Human mutation.

[32]  P. Saftig,et al.  Cathepsin D deficiency is associated with a human neurodegenerative disorder. , 2006, American journal of human genetics.

[33]  D. Neary,et al.  Genetic associations between cathepsin D exon 2 C→T polymorphism and Alzheimer’s disease, and pathological correlations with genotype , 2006, Journal of Neurology, Neurosurgery & Psychiatry.

[34]  N. Katunuma,et al.  Processing of human cathepsin D is independent of its catalytic function and auto-activation: involvement of cathepsins L and B. , 2006, Journal of biochemistry.

[35]  H. Grosch,et al.  Purified recombinant human prosaposin forms oligomers that bind procathepsin D and affect its autoactivation. , 2004, The Biochemical journal.

[36]  G. Serrero,et al.  PC cell-derived growth factor (PCDGF/GP88, progranulin) stimulates migration, invasiveness and VEGF expression in breast cancer cells. , 2004, Carcinogenesis.

[37]  Matthew Bogyo,et al.  Cathepsin V, a Novel and Potent Elastolytic Activity Expressed in Activated Macrophages* , 2004, Journal of Biological Chemistry.

[38]  J. Estève,et al.  Keeping Data Continuous when Analyzing the Prognostic Impact of a Tumor Marker: An Example with Cathepsin D in Breast Cancer , 2003, Breast Cancer Research and Treatment.

[39]  B. Dunn.  Structure and mechanism of the pepsin-like family of aspartic peptidases. , 2002, Chemical reviews.

[40]  F. Jessen,et al.  Cerebrospinal fluid levels of &bgr;-amyloid(42) in patients with Alzheimer's disease are related to the exon 2 polymorphism of the cathepsin D gene , 2002 .

[41]  L. Juliano,et al.  Cathepsin B Activity Regulation , 2001, The Journal of Biological Chemistry.

[42]  M. Baumann,et al.  A mutation in the ovine cathepsin D gene causes a congenital lysosomal storage disease with profound neurodegeneration , 2000, The EMBO journal.

[43]  W. Vranken,et al.  Design and solution structure of a well-folded stack of two beta-hairpins based on the amino-terminal fragment of human granulin A. , 2000, Biochemistry.

[44]  J. Pauls,et al.  A genetic variation of cathepsin D is a major risk factor for Alzheimer's disease , 2000, Annals of neurology.

[45]  V. Turk,et al.  Autocatalytic processing of recombinant human procathepsin B is a bimolecular process , 1999, FEBS letters.

[46]  D. Stover,et al.  Mechanisms and kinetics of procathepsin D activation. , 1999, European journal of biochemistry.

[47]  A. Bateman,et al.  Progranulin gene expression regulates epithelial cell growth and promotes tumor growth in vivo. , 1999, Cancer research.

[48]  V. Vetvicka,et al.  Analysis of the interaction of procathepsin D activation peptide with breast cancer cells , 1997, International journal of cancer.

[49]  J. Chirgwin,et al.  Role of glycosylation in the expression of human procathepsin D. , 1995, Journal of cell science.

[50]  V. Vetvicka,et al.  Effect of human procathepsin D on proliferation of human cell lines. , 1994, Cancer letters.

[51]  G. Conner,et al.  Isolation and characterization of a stable activation intermediate of the lysosomal aspartyl protease cathepsin D. , 1992, Biochemistry.

[52]  Y. Kishimoto,et al.  Saposin proteins: structure, function, and role in human lysosomal storage disorders , 1991, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[53]  A. Samarel,et al.  Effects of cysteine protease inhibitors on rabbit cathepsin D maturation. , 1989, The American journal of physiology.

[54]  H. Rochefort,et al.  Autocrine growth stimulation of the MCF 7 breast cancer cells by the estrogen-regulated 52 K protein. , 1986, Endocrinology.

[55]  M. James,et al.  Molecular structure of an aspartic proteinase zymogen, porcine pepsinogen, at 1.8 Å resolution , 1986, Nature.

[56]  K. von Figura,et al.  Processing of human cathepsin D in lysosomes in vitro. , 1985, The Journal of biological chemistry.

[57]  K. von Figura,et al.  Lysosomal enzyme precursors in human fibroblasts. Activation of cathepsin D precursor in vitro and activity of beta-hexosaminidase A precursor towards ganglioside GM2. , 1982, European journal of biochemistry.

[58]  G. Blobel,et al.  Biosynthesis of a lysosomal enzyme. Partial structure of two transient and functionally distinct NH2-terminal sequences in cathepsin D. , 1981, The Journal of biological chemistry.

[59]  I. Touitou,et al.  Missense polymorphism (C/T224) in the human cathepsin D pro-fragment determined by polymerase chain reaction--single strand conformational polymorphism analysis and possible consequences in cancer cells. , 1994, European journal of cancer.

[60]  K. von Figura,et al.  Lysosomal enzymes and their receptors. , 1986, Annual review of biochemistry.