Identification of Models for Glucose Blood Values in Diabetics by Grammatical Evolution

One the most relevant application areas of artificial intelligence and machine learning in general is medical research. We here focus on research dedicated to diabetes, a disease that affects a high percentage of the population worldwide and that is an increasing threat due to the advance of the sedentary life in the big cities. Most recent studies estimate that it affects about more than 410 million people in the world. In this chapter we discuss a set of techniques based on GE to obtain mathematical models of the evolution of blood glucose along the time. These models help diabetic patients to improve the control of blood sugar levels and thus, improve their quality of life. We summarize some recent works on data preprocessing and design of grammars that have proven to be valuable in the identification of prediction models for type 1 diabetics. Furthermore, we explain the data augmentation method which is used to sample new data sets.

[1]  Martin A. Tanner,et al.  From EM to Data Augmentation: The Emergence of MCMC Bayesian Computation in the 1980s , 2010, 1104.2210.

[2]  José Ignacio Hidalgo,et al.  Compilable Phenotypes: Speeding-Up the Evaluation of Glucose Models in Grammatical Evolution , 2016, EvoApplications.

[3]  Anthony Brabazon,et al.  Foundations in Grammatical Evolution for Dynamic Environments , 2009, Studies in Computational Intelligence.

[4]  W. Ward,et al.  A review of artificial pancreas technologies with an emphasis on bi‐hormonal therapy , 2013, Diabetes, obesity & metabolism.

[5]  D. Cox,et al.  Evaluating Clinical Accuracy of Systems for Self-Monitoring of Blood Glucose , 1987, Diabetes Care.

[6]  José Ignacio Hidalgo,et al.  Modeling glycemia in humans by means of Grammatical Evolution , 2014, Appl. Soft Comput..

[7]  Sébastien Vérel,et al.  Local Optima Networks of NK Landscapes With Neutrality , 2011, IEEE Transactions on Evolutionary Computation.

[8]  Conor Ryan A rebuttal to Whigham, Dick, and Maclaurin by one of the inventors of Grammatical Evolution: Commentary on “On the Mapping of Genotype to Phenotype in Evolutionary Algorithms” by Peter A. Whigham, Grant Dick, and James Maclaurin , 2017, Genetic Programming and Evolvable Machines.

[9]  Lovekesh Vig,et al.  ODE - Augmented Training Improves Anomaly Detection in Sensor Data from Machines , 2016, ArXiv.

[10]  Joaquín Aranda,et al.  Symbolic Regression for Marine Vehicles Identification , 2015 .

[11]  Heinz Mühlenbein,et al.  The Equation for Response to Selection and Its Use for Prediction , 1997, Evolutionary Computation.

[12]  José Ignacio Hidalgo,et al.  Predicting Glycemia in Diabetic Patients By Evolutionary Computation and Continuous Glucose Monitoring , 2016, GECCO.

[13]  Grant Dick,et al.  On the mapping of genotype to phenotype in evolutionary algorithms , 2017, Genetic Programming and Evolvable Machines.

[14]  José Ignacio Hidalgo,et al.  glUCModel: A monitoring and modeling system for chronic diseases applied to diabetes , 2014, J. Biomed. Informatics.

[15]  José Ignacio Hidalgo,et al.  Data Based Prediction of Blood Glucose Concentrations Using Evolutionary Methods , 2017, Journal of Medical Systems.

[16]  Lenore Cowen,et al.  Augmented training of hidden Markov models to recognize remote homologs via simulated evolution , 2009, Bioinform..

[17]  Conor Ryan,et al.  Grammatical Evolution by Grammatical Evolution: The Evolution of Grammar and Genetic Code , 2004, EuroGP.

[18]  José Ignacio Hidalgo,et al.  Data-Based Identification of Prediction Models for Glucose , 2015, GECCO.

[19]  José Ignacio Hidalgo,et al.  Enhancing Grammatical Evolution Through Data Augmentation: Application to Blood Glucose Forecasting , 2017, EvoApplications.

[20]  J. Weissberg-Benchell,et al.  Insulin pump therapy: a meta-analysis. , 2003, Diabetes care.

[21]  Sébastien Vérel,et al.  A study of NK landscapes' basins and local optima networks , 2008, GECCO '08.

[22]  Michael Affenzeller,et al.  Complexity Measures for Multi-objective Symbolic Regression , 2015, EUROCAST.

[23]  B H Ginsberg,et al.  A new consensus error grid to evaluate the clinical significance of inaccuracies in the measurement of blood glucose. , 2000, Diabetes care.

[24]  S. Shapiro,et al.  An Analysis of Variance Test for Normality (Complete Samples) , 1965 .

[25]  Giovanni Sparacino,et al.  Glucose Concentration can be Predicted Ahead in Time From Continuous Glucose Monitoring Sensor Time-Series , 2007, IEEE Transactions on Biomedical Engineering.

[26]  Birtha Hansen,et al.  Insulin administration: selecting the appropriate needle and individualizing the injection technique , 2011, Expert opinion on drug delivery.

[27]  Martin Pelikan,et al.  Marginal Distributions in Evolutionary Algorithms , 2007 .