Membrane Inlet Mass Spectrometry for Homeland Security and Forensic Applications

AbstractA man-portable membrane inlet mass spectrometer has been built and tested to detect and monitor characteristic odors emitted from the human body and also from threat substances. In each case, a heated membrane sampling probe was used. During human scent monitoring experiments, data were obtained for inorganic gases and volatile organic compounds emitted from human breath and sweat in a confined space. Volatile emissions were detected from the human body at low ppb concentrations. Experiments with compounds associated with narcotics, explosives, and chemical warfare agents were conducted for a range of membrane types. Test compounds included methyl benzoate (odor signature of cocaine), piperidine (precursor in clandestine phencyclidine manufacturing processes), 2-nitrotoluene (breakdown product of TNT), cyclohexanone (volatile signature of plastic explosives), dimethyl methylphosphonate (used in sarin and soman nerve agent production), and 2-chloroethyl ethyl sulfide (simulant compound for sulfur mustard gas). Gas phase calibration experiments were performed allowing sub-ppb LOD to be established. The results showed excellent linearity versus concentration and rapid membrane response times. Graphical Abstractᅟ

[1]  R. M. Ferguson,et al.  A coaxially heated membrane introduction mass spectrometry interface for the rapid and sensitive on-line measurement of volatile and semi-volatile organic contaminants in air and water at parts-per-trillion levels. , 2006, Rapid communications in mass spectrometry : RCM.

[2]  J. Namieśnik,et al.  Development of Techniques of Generation of Gaseous Standard Mixtures , 2005 .

[3]  M Statheropoulos,et al.  The trapped human experiment , 2011, Journal of breath research.

[4]  J. Yinon,et al.  Peer Reviewed: Detection of Explosives by Electronic Noses , 2003 .

[5]  David Smith,et al.  A longitudinal study of ammonia, acetone and propanol in the exhaled breath of 30 subjects using selected ion flow tube mass spectrometry, SIFT-MS , 2006, Physiological measurement.

[6]  Chuji Wang,et al.  Breath Analysis Using Laser Spectroscopic Techniques: Breath Biomarkers, Spectral Fingerprints, and Detection Limits , 2009, Sensors.

[7]  Yehuda Zeiri,et al.  Raman and Infrared Fingerprint Spectroscopy of Peroxide-Based Explosives , 2008, Applied spectroscopy.

[8]  G. Bastiaans,et al.  Detection and identification of explosive RDX by THz diffuse reflection spectroscopy. , 2006, Optics express.

[9]  Andreas Natsch,et al.  Body odour of monozygotic human twins: a common pattern of odorant carboxylic acids released by a bacterial aminoacylase from axilla secretions contributing to an inherited body odour type , 2009, Journal of The Royal Society Interface.

[10]  M Statheropoulos,et al.  Preliminary investigation of using volatile organic compounds from human expired air, blood and urine for locating entrapped people in earthquakes. , 2005, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[11]  W. Potts,et al.  Chemical signals and parasite-mediated sexual selection. , 1998, Trends in ecology & evolution.

[12]  Laurent Dormont,et al.  Human Skin Volatiles: A Review , 2013, Journal of Chemical Ecology.

[13]  P. H. Hemberger,et al.  Membrane introduction mass spectrometry: trends and applications. , 2000, Mass spectrometry reviews.

[14]  The Direct Analysis of Semi-volatile Organic Compounds by Membrane Introduction Mass Spectrometry , 1997 .

[15]  M Statheropoulos,et al.  A study of volatile organic compounds evolved from the decaying human body. , 2005, Forensic science international.

[16]  D. Singh,et al.  Female body odour is a potential cue to ovulation , 2001, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[17]  K Wells,et al.  A review of X-ray explosives detection techniques for checked baggage. , 2012, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[18]  M. Phillips,et al.  Method for the collection and analysis of volatile compounds in the breath. , 1991, Journal of chromatography.

[19]  R. Cataneo,et al.  Volatile organic compounds in breath as markers of lung cancer: a cross-sectional study , 1999, The Lancet.

[20]  Antonella Macagnano,et al.  Human skin odor analysis by means of an electronic nose , 2000 .

[21]  T. Märk,et al.  Investigation of fundamental physical properties of a polydimethylsiloxane (PDMS) membrane using a proton transfer reaction mass spectrometer (PTRMS) , 2004 .

[22]  Kenneth G. Furton,et al.  Analysis of the Uniqueness and Persistence of Human Scent , 2005 .

[23]  S. Telser,et al.  Applications of breath gas analysis in medicine , 2004 .

[24]  Karl Grammer,et al.  The scent of fear. , 2002, Neuro endocrinology letters.

[25]  J. Mattai,et al.  Detection and quantification of apocrine secreted odor‐binding protein on intact human axillary skin , 2004, International journal of cosmetic science.

[26]  David S. Moore,et al.  Recent Advances in Trace Explosives Detection Instrumentation , 2007 .

[27]  Boris Brkić,et al.  Monitoring of human chemical signatures using membrane inlet mass spectrometry. , 2014, Analytical chemistry.

[28]  David Smith,et al.  A longitudinal study of ethanol and acetaldehyde in the exhaled breath of healthy volunteers using selected-ion flow-tube mass spectrometry. , 2006, Rapid communications in mass spectrometry : RCM.

[29]  J. Yinon,et al.  Detection of explosives by electronic noses , 2003 .

[30]  Willem Takken,et al.  Sweaty skin: an invitation to bite? , 2011, Trends in parasitology.

[31]  T. M. Allen,et al.  Environmental applications of membrane introduction mass spectrometry. , 2002, Journal of mass spectrometry : JMS.

[32]  S Haze,et al.  2-Nonenal newly found in human body odor tends to increase with aging. , 2001, The Journal of investigative dermatology.

[33]  Hian Kee Lee,et al.  Headspace liquid-phase microextraction of chlorobenzenes in soil with gas chromatography-electron capture detection. , 2003, Analytical chemistry.

[34]  David Smith,et al.  A longitudinal study of methanol in the exhaled breath of 30 healthy volunteers using selected ion flow tube mass spectrometry, SIFT-MS , 2006, Physiological measurement.

[35]  Sergio Armenta,et al.  A review of recent, unconventional applications of ion mobility spectrometry (IMS). , 2011, Analytica chimica acta.

[36]  P. Španěl,et al.  A longitudinal study of breath isoprene in healthy volunteers using selected ion flow tube mass spectrometry (SIFT-MS) , 2006, Physiological measurement.

[37]  R. Cooks,et al.  Single-sided membrane introduction mass spectrometry for on-line determination of semi-volatile organic compounds in air. , 2001, The Analyst.

[38]  C. Wysocki,et al.  Analyses of volatile organic compounds from human skin , 2008, The British journal of dermatology.

[39]  H. Meuzelaar,et al.  Roving GC/MS: Mapping VOC gradients and trends in space and time , 1996 .

[40]  Boris Brkić,et al.  Oil-in-water monitoring using membrane inlet mass spectrometry. , 2011, Analytical chemistry.

[41]  Zheng Ouyang,et al.  Handheld miniature ion trap mass spectrometers. , 2009, Analytical chemistry.

[42]  R. Cooks,et al.  Improved detection of low vapor pressure compounds in air by serial combination of single-sided membrane introduction with fiber introduction mass spectrometry (SS-MIMS-FIMS). , 2005, The Analyst.

[43]  T. Märk,et al.  Membrane inlet proton transfer reaction mass spectrometry (MI-PTRMS) for direct measurements of VOCs in water , 2004 .

[44]  D. Penn,et al.  Individual and Gender Fingerprints in Body Odour , 2007 .