Heme oxygenase-1 mediates the protective role of quercetin against ethanol-induced rat hepatocytes oxidative damage.

[1]  Liegang Liu,et al.  Quercetin protects against ethanol-induced oxidative damage in rat primary hepatocytes. , 2010, Toxicology in vitro : an international journal published in association with BIBRA.

[2]  S. Ryter,et al.  Protective functions of heme oxygenase-1 and carbon monoxide in the respiratory system. , 2007, Antioxidants & redox signaling.

[3]  Liegang Liu,et al.  Heme oxygenase-1 upregulated by Ginkgo biloba extract: potential protection against ethanol-induced oxidative liver damage. , 2007, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[4]  A. Nussler,et al.  Quercetin protects human hepatocytes from ethanol-derived oxidative stress by inducing heme oxygenase-1 via the MAPK/Nrf2 pathways. , 2007, Journal of hepatology.

[5]  B. Wung,et al.  Piceatannol upregulates endothelial heme oxygenase-1 expression via novel protein kinase C and tyrosine kinase pathways. , 2006, Pharmacological research.

[6]  Stefan O Mueller,et al.  Effects of cell culture conditions on primary rat hepatocytes-cell morphology and differential gene expression. , 2006, Toxicology.

[7]  J. González‐Gallego,et al.  Quercetin decreases oxidative stress, NF-kappaB activation, and iNOS overexpression in liver of streptozotocin-induced diabetic rats. , 2005, The Journal of nutrition.

[8]  Hui-Yi Lin,et al.  Quercetin, but not rutin and quercitrin, prevention of H2O2-induced apoptosis via anti-oxidant activity and heme oxygenase 1 gene expression in macrophages. , 2005, Biochemical pharmacology.

[9]  R. McCuskey,et al.  Ethanol binging exacerbates sinusoidal endothelial and parenchymal injury elicited by acetaminophen. , 2005, Journal of hepatology.

[10]  J. Jia,et al.  Treatment of patients with alcoholic liver disease. , 2005, Hepatobiliary & pancreatic diseases international : HBPD INT.

[11]  U. Settmacher,et al.  Heme oxygenase-1 protects human hepatocytes in vitro against warm and cold hypoxia. , 2004, Journal of hepatology.

[12]  C. Mancuso.  Heme oxygenase and its products in the nervous system. , 2004, Antioxidants & redox signaling.

[13]  A. Nussler,et al.  Induction of heme oxygenase-1 in human hepatocytes to protect them from ethanol-induced cytotoxicity. , 2004, Biomedical and environmental sciences : BES.

[14]  C. B. Pickett,et al.  The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress. , 2004, Free radical biology & medicine.

[15]  T. Cheng,et al.  Mechanism of Heme Oxygenase-1 Gene Induction by Quercetin in Rat Aortic Smooth Muscle Cells , 2004, Pharmacology.

[16]  C. Rice-Evans,et al.  Flavonoids: antioxidants or signalling molecules? , 2004, Free radical biology & medicine.

[17]  A. I. Rojo,et al.  Regulation of Heme Oxygenase-1 Expression through the Phosphatidylinositol 3-Kinase/Akt Pathway and the Nrf2 Transcription Factor in Response to the Antioxidant Phytochemical Carnosol* , 2004, Journal of Biological Chemistry.

[18]  A. Cederbaum,et al.  Oxidative stress, toxicology, and pharmacology of CYP2E1. , 2004, Annual review of pharmacology and toxicology.

[19]  I. Iglesias,et al.  Quercetin, a flavonoid antioxidant, prevents and protects against ethanol-induced oxidative stress in mouse liver. , 2003, Biological & pharmaceutical bulletin.

[20]  K. Nakahira,et al.  Protective role of heme oxygenase-1 induction in carbon tetrachloride-induced hepatotoxicity. , 2003, Biochemical pharmacology.

[21]  Carl G. Figdor,et al.  Different Faces of the Heme-Heme Oxygenase System in Inflammation , 2003, Pharmacological Reviews.

[22]  K. Nakashima,et al.  PI3K is a key molecule in the Nrf2‐mediated regulation of antioxidative proteins by hemin in human neuroblastoma cells , 2003, FEBS letters.

[23]  T. Kietzmann,et al.  Transcriptional Regulation of Heme Oxygenase-1 Gene Expression by MAP Kinases of the JNK and p38 Pathways in Primary Cultures of Rat Hepatocytes* , 2003, The Journal of Biological Chemistry.

[24]  A. Ohlmann,et al.  Regulation of Heme Oxygenase-1 Gene Expression by Anoxia and Reoxygenation in Primary Rat Hepatocyte Cultures , 2003, Experimental biology and medicine.

[25]  A. Kahraman,et al.  The antioxidative and antihistaminic properties of quercetin in ethanol-induced gastric lesions. , 2003, Toxicology.

[26]  Morihiro Okada,et al.  Nerve growth factor protects against aluminum-mediated cell death. , 2002, Toxicology.

[27]  S. Doré.  Decreased activity of the antioxidant heme oxygenase enzyme: implications in ischemia and in Alzheimer's disease. , 2002, Free radical biology & medicine.

[28]  V. Calabrese,et al.  Caffeic acid phenethyl ester and curcumin: a novel class of heme oxygenase-1 inducers. , 2002, Molecular pharmacology.

[29]  Defeng Wu,et al.  CYP2E1-dependent toxicity and oxidative stress in HepG2 cells. , 2001, Free radical biology & medicine.

[30]  C. T. Migita,et al.  Mechanism of heme degradation by heme oxygenase. , 2000, Journal of inorganic biochemistry.

[31]  G. Ramadori,et al.  Gene regulation of heme oxygenase-1 as a therapeutic target. , 2000, Biochemical pharmacology.

[32]  H. Bonkovsky,et al.  Induction of the heme oxygenase-1 gene by metalloporphyrins. , 2000, Archives of biochemistry and biophysics.

[33]  D. Willis,et al.  Heme oxygenase isoform expression in cellular and antibody‐mediated models of acute inflammation in the rat , 2000, The Journal of pathology.

[34]  C. A. Musonda,et al.  Quercetin inhibits hydrogen peroxide (H2O2)-induced NF-kappaB DNA binding activity and DNA damage in HepG2 cells. , 1998, Carcinogenesis.

[35]  M. Abdel‐Rahman,et al.  Ethanol does not increase the hepatotoxicity of cocaine in primary rat hepatocyte culture. , 1998, Toxicology.

[36]  M. Lean,et al.  Effects of flavonoids and vitamin C on oxidative DNA damage to human lymphocytes. , 1998, The American journal of clinical nutrition.

[37]  M. Maines,et al.  Isolation and characterization of a cDNA from the rat brain that encodes hemoprotein heme oxygenase-3. , 1997, European journal of biochemistry.

[38]  M. Suematsu,et al.  Carbon monoxide: an endogenous modulator of sinusoidal tone in the perfused rat liver. , 1995, The Journal of clinical investigation.

[39]  L. Góth,et al.  A simple method for determination of serum catalase activity and revision of reference range. , 1991, Clinica chimica acta; international journal of clinical chemistry.

[40]  M. Hørder,et al.  International Federation of Clinical Chemistry (IFCC) Scientific Committee, Analytical Section: approved recommendation (1985) on IFCC methods for the measurement of catalytic concentration of enzymes. Part 2. IFCC method for aspartate aminotransferase (L-aspartate: 2-oxoglutarate aminotransferase, , 1986 .

[41]  R. Roeder,et al.  Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. , 1983, Nucleic acids research.

[42]  H. Bergmeyer.  IFCC methods for the measurement of catalytic concentrations of enzymes: Part 3. IFCC method for alanine aminotransferase (L-alanine: 2-oxoglutarate aminotransferase, EC 2.6.1.2)☆ , 1980 .

[43]  B. Mannervik,et al.  Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. , 1979, Biochimica et biophysica acta.

[44]  Y. Kono.  Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase. , 1978, Archives of biochemistry and biophysics.

[45]  Oliver H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.

[46]  H. Forman,et al.  Redox signaling and the MAP kinase pathways , 2003, BioFactors.

[47]  Y. Niida,et al.  Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. , 1999, The Journal of clinical investigation.

[48]  V. Calabrese,et al.  Stress proteins and SH-groups in oxidant-induced cell damage after acute ethanol administration in rat. , 1996, Free radical biology & medicine.

[49]  C. Rice-Evans,et al.  Structure-antioxidant activity relationships of flavonoids and phenolic acids. , 1996, Free radical biology & medicine.

[50]  H. Rouach,et al.  Implication of free radical mechanisms in ethanol-induced cellular injury. , 1992, Free radical biology & medicine.

[51]  S. Aust,et al.  Microsomal lipid peroxidation. , 1978, Methods in enzymology.