Chorea and contraceptives: Case report with pet study and review of the literature

Chorea is a well‐recognized but rare complication of oral contraceptive use. A 27‐year‐old woman developed right hemichorea while taking an oral contraceptive (OC). No other causes of chorea were found. A positron emission tomography (PET) study with 18F‐fluorodeoxyglucose demonstrated a dense focus of increased glucose metabolism involving the body of the left caudate nucleus. To our knowledge, this is the first report of a PET study in a patient with OC‐induced chorea in the absence of systemic lupus erythematosus or antiphospholipid antibodies. © 2003 Movement Disorder Society

[1]  H. Herzog,et al.  Normal striatal glucose consumption in two patients with benign hereditary chorea as measured by positron emission tomography , 1990, Journal of Neurology.

[2]  H. Fukuda,et al.  A new diagnostic method for chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma based on serum metallothionein, copper, and zinc levels. , 2002, Biological & pharmaceutical bulletin.

[3]  B. Şaylan,et al.  Sydenham's chorea: clinical findings and comparison of the efficacies of sodium valproate and carbamazepine regimens , 2002, Brain and Development.

[4]  J. Vandenbroucke,et al.  Female hormones and thrombosis. , 2002, Arteriosclerosis, thrombosis, and vascular biology.

[5]  M. Terreri,et al.  Sydenham's chorea - clinical and evolutive characteristics , 2002, Sao Paulo medical journal = Revista paulista de medicina.

[6]  A. Danek,et al.  Reduction of striatal glucose metabolism in McLeod choreoacanthocytosis , 2001, Journal of neurology, neurosurgery, and psychiatry.

[7]  T. Klockgether,et al.  Chorea and antiphospholipid antibodies: Treatment with methotrexate , 2001, Neurology.

[8]  M. Mańczak,et al.  Oxidase activity of ceruloplasmin and concentrations of copper and zinc in serum of cancer patients. , 2001, Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements.

[9]  S. Lo,et al.  Estrogen improves motor disability in parkinsonian postmenopausal women with motor fluctuations , 2000, Neurology.

[10]  P. Blanchet,et al.  Short-term effects of high-dose 17β-estradiol in postmenopausal PD patients , 1999, Neurology.

[11]  P. Orellana,et al.  [Chorea induced by oral contraceptives. Report of two cases]. , 1999, Revista medica de Chile.

[12]  H. Brenner,et al.  Effect of oral contraceptive progestins on serum copper concentration , 1998, European Journal of Clinical Nutrition.

[13]  D. Milne,et al.  Copper intake and assessment of copper status. , 1998, The American journal of clinical nutrition.

[14]  S. Aquilonius,et al.  Reversible chorea in primary antiphospholipid syndrome , 1998, Movement disorders : official journal of the Movement Disorder Society.

[15]  Á. Chamorro,et al.  Chorea in the Antiphospholipid Syndrome: Clinical, Radiologic, and Immunologic Characteristics of 50 Patients from Our Clinics and the Recent Literature , 1997, Medicine.

[16]  T. Ishikawa,et al.  Alternating hemichorea in primary antiphospholipid syndrome , 1994, Neurology.

[17]  A. Luxen,et al.  Reversible striatal hypermetabolism in a case of sydenham's chorea , 1993, Movement disorders : official journal of the Movement Disorder Society.

[18]  N. Quinn,et al.  Hormone replacement therapy induced chorea. , 1991, BMJ.

[19]  M. Muenter,et al.  An unusual cause of recurrent chorea , 1991, Movement disorders : official journal of the Movement Disorder Society.

[20]  J. Palermo-neto,et al.  Influences of estrogen and/or progesterone on some dopamine related behavior in rats. , 1990, General pharmacology.

[21]  G. Hughes,et al.  The “Primary” Antiphospholipid Syndrome: Major Clinical and Serological Features , 1989, Medicine.

[22]  K. Ma,et al.  Chorea as the initial presentation of oral contraceptive related systemic lupus erythematosus. , 1989 .

[23]  Gatter Ra,et al.  Chorea as the initial presentation of oral contraceptive induced systemic lupus erythematosus. , 1988 .

[24]  G. Hughes,et al.  Complications of oral contraceptives and antiphospholipid antibodies: reply to the letter by Bruneau et al. , 1988, Arthritis and rheumatism.

[25]  Hughes Gr,et al.  Antiphospholipid antibodies and chorea. , 1988 .

[26]  E. Wolters,et al.  Oral contraceptive induced paraballism , 1987, Clinical Neurology and Neurosurgery.

[27]  G. Hughes,et al.  Chorea in systemic lupus erythematosus and "lupus-like" disease: association with antiphospholipid antibodies. , 1987, Seminars in arthritis and rheumatism.

[28]  C. Nahmias,et al.  Regional cerebral glucose metabolism in SLE chorea: Further evidence that striatal hypometabolism is not a correlate of chorea , 1987, Movement disorders : official journal of the Movement Disorder Society.

[29]  R. Hichwa,et al.  PET scan investigations of Huntington's disease: Cerebral metabolic correlates of neurological features and functional decline , 1986, Annals of neurology.

[30]  M. Dougados,et al.  Human parvovirus arthropathy. , 1986, Arthritis and rheumatism.

[31]  W. Koller,et al.  Estrogen treatment of dyskinetic disorders , 1982, Neurology.

[32]  W. Wadlington,et al.  Chorea Associated with the Use of Oral Contraceptives , 1981, Clinical pediatrics.

[33]  P. Green Chorea induced by oral contraceptives , 1980, Neurology.

[34]  P. Bédard,et al.  Female sexual hormones influence motor behaviour in rats after lesion of the entopeduncular nucleus , 1980, Neuroscience Letters.

[35]  D. Dove,et al.  Chorea associated with oral contraceptive therapy. , 1980, American journal of obstetrics and gynecology.

[36]  W. Weiner,et al.  Chorea induced by oral contraceptives , 1979, Neurology.

[37]  W. Weiner,et al.  Modification of postsynaptic dopaminergic sensitivity by female sex hormones. , 1979, Life sciences.

[38]  E. T. Gamboa,et al.  Chorea associated with oral contraceptive therapy. , 1971, Archives of neurology.

[39]  E. Bickerstaff Involuntary movements and the pill. , 1969, British medical journal.

[40]  F. Sj An attack of chorea complicating oral contraceptive therapy. , 1966 .