Non-thermal Biological Effects of Microwaves

The aim of this paper is to overview the diverse biological effects of non-thermal microwaves (NT MWs) and complex dependence of these effects on various physical and biological parameters. Besides dependencies on frequency and modulation, the available data suggest dependencies of the NT MW effects on intermittence and coherence time of exposure, polarization, static magnetic filed, electromagnetic stray field, genotype, gender, physiological and individual factors, cell density during of exposure and indicate that duration of exposure may be not less important than power density (PD) for the NT MW effects. Further evaluation of these dependencies are needed for understanding the mechanisms by which NT MWs affect biological systems, planning in vivo and epidemiological studies, developing medical treatments, setting safety standards, and minimizing the adverse effects of MWs from mobile communication.

[1]  W. R. Adey,et al.  DNA synthesis and cell proliferation in C6 glioma and primary glial cells exposed to a 836.55 MHz modulated radiofrequency field. , 1997, Bioelectromagnetics.

[2]  B. Costall,et al.  Mobile phone use facilitates memory in male, but not female, subjects , 2003, Neuroreport.

[3]  I. Belyaev,et al.  Resonance Effect of Microwaves on the Genome Conformational State of E. coli Cells , 1992, Zeitschrift für Naturforschung C - A Journal of Biosciences.

[4]  D Krause,et al.  Bioeffects induced by exposure to microwaves are mitigated by superposition of ELF noise. , 1997, Bioelectromagnetics.

[5]  N. Kuster,et al.  Exposure to pulse‐modulated radio frequency electromagnetic fields affects regional cerebral blood flow , 2005, The European journal of neuroscience.

[6]  C. Papageorgiou,et al.  Gender related differences on the EEG during a simulated mobile phone signal , 2004, Neuroreport.

[7]  Selection Rules on Helicity during Discrete Transitions of the Genome Conformational State in Intact and X-Rayed Cells of E.Coli in Millimeter Range of Electromagnetic Field , 1992 .

[8]  M. Geffard,et al.  Antibody responses of mice exposed to low-power microwaves under combined, pulse-and-amplitude modulation. , 1991, Bioelectromagnetics.

[9]  I. Belyaev,et al.  Effect of static magnetic field on E. coli cells and individual rotations of ion-protein complexes. , 2001, Bioelectromagnetics.

[10]  Kravchenko Vg,et al.  Resonance effect of low-intensity millimeter waves on the chromatin conformational state of rat thymocytes , 1994 .

[11]  S Banik,et al.  Bioeffects of microwave--a brief review. , 2003, Bioresource technology.

[12]  I. Belyaev,et al.  Evidence for Dependence of Resonant Frequency of Millimeter Wave Interaction with Escherichia coli K12 Cells on Haploid Genome Length , 1993 .

[13]  Franz Adlkofer,et al.  Non-thermal DNA breakage by mobile-phone radiation (1800 MHz) in human fibroblasts and in transformed GFSH-R17 rat granulosa cells in vitro. , 2005, Mutation research.

[14]  M. Protopopova,et al.  915 MHz microwaves and 50 Hz magnetic field affect chromatin conformation and 53BP1 foci in human lymphocytes from hypersensitive and healthy persons , 2005, Bioelectromagnetics.

[15]  Vladimir N. Binhi,et al.  Magnetobiology: Underlying Physical Problems , 2002 .

[16]  M. Gulisano,et al.  Exposure to global system for mobile communication (GSM) cellular phone radiofrequency alters gene expression, proliferation, and morphology of human skin fibroblasts. , 2002, Oncology research.

[17]  K. H. Mild,et al.  Use of cellular or cordless telephones and the risk for non-Hodgkin’s lymphoma , 2005, International archives of occupational and environmental health.

[18]  Niels Kuster,et al.  The FASEB Journal express article 10.1096/fj.04-3549fje. Published online August 22, 2005. , 2022 .

[19]  I. Belyaev,et al.  Resonance Effect of Low-Intensity Millimeter Waves on the Chromatin Conformational State of Rat Thymocytes , 1994, Zeitschrift fur Naturforschung. C, Journal of biosciences.

[20]  J. Elder,et al.  Induction of calcium-ion efflux from brain tissue by radiofrequency radiation: effect of sample number and modulation frequency on the power-density window. , 1980, Bioelectromagnetics.

[21]  Mirta Tkalec,et al.  Influence of 400, 900, and 1900 MHz electromagnetic fields on Lemna minor growth and peroxidase activity , 2005, Bioelectromagnetics.

[22]  D. House,et al.  Calcium-ion efflux from brain tissue: power-density versus internal field-intensity dependencies at 50-MHz RF radiation. , 1980, Bioelectromagnetics.

[23]  Lars Malmgren,et al.  Nerve cell damage in mammalian brain after exposure to microwaves from GSM mobile phones. , 2003, Environmental health perspectives.

[24]  S. Kamışlı,et al.  Ginkgo biloba prevents mobile phone-induced oxidative stress in rat brain. , 2004, Clinica chimica acta; international journal of clinical chemistry.

[25]  R. Tarone,et al.  Mobile phone use and acoustic neuromas. , 2005, Epidemiology.

[26]  B Hocking,et al.  Mobile phone use and risk of acoustic neuroma , 2006, British Journal of Cancer.

[27]  B. Persson,et al.  Nonthermal GSM microwaves affect chromatin conformation in human lymphocytes similar to heat shock , 2004, IEEE Transactions on Plasma Science.

[28]  Henry C. Lai Biological Effects of Radiofrequency Electromagnetic Field , 2005 .

[29]  A. Pakhomov,et al.  A Comprehensive Review of the Research on Biological Effects of Pulsed Radiofrequency Radiation in Russia and the Former Soviet Union , 2000 .

[30]  A. Ahlbom Guidelines for limiting exposure to time-varying electric, magnetic, and electromagnetic fields (up to 300 GHz) , 1998 .

[31]  C. Blackman,et al.  Power density, field intensity, and carrier frequency determinants of RF-energy-induced calcium-ion efflux from brain tissue. , 1980, Bioelectromagnetics.

[32]  W. Heyer,et al.  Extremely high frequency electromagnetic fields at low power density do not affect the division of exponential phase Saccharomyces cerevisiae cells. , 1997, Bioelectromagnetics.

[33]  I. Belyaev Some biophysical aspects of the genetic effect of low-intensity millimeter waves , 1992 .

[34]  W. Grundler Intensity- and frequency-dependent effects of microwaves on cell growth rates , 1992 .

[35]  W. R. Adey,et al.  Effects of weak amplitude-modulated microwave fields on calcium efflux from awake cat cerebral cortex. , 1982, Bioelectromagnetics.

[36]  F. Kaiser Coherent oscillations - their role in the interaction of weak ELM-fields with cellular systems , 1995 .

[37]  I. Belyaev,et al.  Regularities of separate and combined effects of circularly polarized millimeter waves on E. coli cells at different phases of culture growth , 1993 .

[38]  D Krause,et al.  Role of modulation on the effect of microwaves on ornithine decarboxylase activity in L929 cells. , 1997, Bioelectromagnetics.

[39]  N. D. Devyatkov,et al.  Low intensity millimeter waves in medicine and biology. , 2000, Critical reviews in biomedical engineering.

[40]  I. Belyaev,et al.  Cell-to-cell communication in response of E. coli cells at different phases of growth to low-intensity microwaves. , 2002, Biochimica et biophysica acta.

[41]  I. Belyaev,et al.  COOPERATIVE RESPONSE OF ESCHERICHIA COLI CELLS TO THE RESONANCE EFFECT OF MILLIMETER WAVES AT SUPER LOW INTENSITY , 1994 .

[42]  W. R. Adey,et al.  Increased ornithine decarboxylase activity in cultured cells exposed to low energy modulated microwave fields and phorbol ester tumor promoters. , 1988, Cancer research.

[43]  Gert Frølund Pedersen,et al.  Review of Radio Science 1996-1999 , 1999 .

[44]  Lennart Hardell,et al.  MOBILE TELEPHONES AND CANCER—A REVIEW OF EPIDEMIOLOGICAL EVIDENCE , 2004, Journal of toxicology and environmental health. Part B, Critical reviews.

[45]  S. Velizarov,et al.  CHANGES IN CELLULAR PROTEINS DUE TO ENVIRONMENTAL NON-IONIZING RADIATION. I. HEAT-SHOCK PROTEINS , 2001 .

[46]  W. R. Adey,et al.  Low frequency amplitude modulated microwave fields change calcium efflux rates from synaptosomes. , 1982, Bioelectromagnetics.

[47]  Jukka Juutilainen,et al.  Apoptosis induced by ultraviolet radiation is enhanced by amplitude modulated radiofrequency radiation in mutant yeast cells , 2004, Bioelectromagnetics.

[48]  H. Lai,et al.  Melatonin and a spin-trap compound block radiofrequency electromagnetic radiation-induced DNA strand breaks in rat brain cells. , 1997, Bioelectromagnetics.

[49]  A Basten,et al.  Lymphomas in E mu-Pim1 transgenic mice exposed to pulsed 900 MHZ electromagnetic fields. , 1997, Radiation research.

[50]  Fehmi Ozguner,et al.  Oxidative Stress‐Mediated Skin Damage in an Experimental Mobile Phone Model Can Be Prevented by Melatonin , 2004, The Journal of dermatology.

[51]  Valentina Maggini,et al.  Individual responsiveness to induction of micronuclei in human lymphocytes after exposure in vitro to 1800-MHz microwave radiation. , 2005, Mutation research.

[52]  I. Belyaev,et al.  Power-Dependent Rearrangement in the Spectrum of Resonance Effect of Millimeter Waves on the Genome Conformational State of Escherichia Coli Cells , 1997 .

[53]  Alwyn C. Scott,et al.  Nonlinear Science: Emergence and Dynamics of Coherent Structures , 1999 .

[54]  I. Belyaev,et al.  Effects of ethidium bromide on DNA loop organisation in human lymphocytes measured by anomalous viscosity time dependence and single cell gel electrophoresis. , 1999, Biochimica et biophysica acta.

[55]  H. Fröhlich Long-range coherence and energy storage in biological systems , 1968 .

[56]  P. Raskmark,et al.  Changes in cell proliferation due to environmental non-ionizing radiation: 2. Microwave radiation , 1998 .

[57]  N. Kuster,et al.  High frequency electromagnetic fields (GSM signals) affect gene expression levels in tumor suppressor p53‐deficient embryonic stem cells , 2004, Bioelectromagnetics.

[58]  Andreas Karabarbounis,et al.  Effect of GSM 900-MHz Mobile Phone Radiation on the Reproductive Capacity of Drosophila melanogaster , 2004 .

[59]  H. Lai,et al.  Single- and double-strand DNA breaks in rat brain cells after acute exposure to radiofrequency electromagnetic radiation. , 1996, International journal of radiation biology.

[60]  I. Belyaev,et al.  Cell-density dependent effects of low-dose ionizing radiation on E. coli cells. , 2003, Radiatsionnaia biologiia, radioecologiia.

[61]  Leeka Kheifets,et al.  Epidemiology of Health Effects of Radiofrequency Exposure , 2004, Environmental health perspectives.

[62]  Fritz Keilmann,et al.  Resonant Cellular Effects of Low Intensity Microwaves , 1988 .

[63]  I. Belyaev,et al.  Chromosome DNA as a Target of Resonant Interaction Between Escherichia Coli Cells and Low–Intensity Millimeter Waves , 1992 .

[64]  W. Stone Cell and Molecular Biology Associated with Radiation Fields of Mobile Telephones , 1999 .

[65]  B. Bianco,et al.  Zeeman-Stark modeling of the RF EMF interaction with ligand binding. , 2000, Bioelectromagnetics.

[66]  L. S. Kinney,et al.  Multiple power-density windows and their possible origin. , 1989, Bioelectromagnetics.

[67]  I. Belyaev,et al.  Existence of selection rules on helicity during discrete transitions of the genome conformational state of E. Coli cells exposed to low-level millimetre radiation , 1992 .

[68]  Guglielmo d'Ambrosio,et al.  Cytogenetic damage in human lymphocytes following GMSK phase modulated microwave exposure , 2002, Bioelectromagnetics.

[69]  I. Belyaev,et al.  Effects of Weak ELF on E. Coli Cells and Human Lymphocytes: Role of Genetic, Physiological, and Physical Parameters , 1999 .

[70]  M. Harms-Ringdahl,et al.  Effects of gamma rays in the 0.5-50-cGy range on the conformation of chromatin in mammalian cells. , 1996, Radiation research.

[71]  Lars Malmgren,et al.  Microwaves from GSM Mobile Telephones Affect 53BP1 and γ-H2AX Foci in Human Lymphocytes from Hypersensitive and Healthy Persons , 2005, Environmental health perspectives.

[72]  I. Belyaev,et al.  COMBINED EFFECTS OF CIRCULARLY POLARIZED MICROWAVES AND ETHIDIUM BROMIDE ON E. coli CELLS , 1999 .

[73]  ICNIRP Guidelines GUIDELINES FOR LIMITING EXPOSURE TO TIME-VARYING , 1998 .

[74]  P Raskmark,et al.  The effects of radiofrequency fields on cell proliferation are non-thermal. , 1999, Bioelectrochemistry and bioenergetics.

[75]  N. Kuster,et al.  Electromagnetic fields, such as those from mobile phones, alter regional cerebral blood flow and sleep and waking EEG , 2002, Journal of sleep research.

[76]  W. R. Adey,et al.  Alterations in protein kinase activity following exposure of cultured human lymphocytes to modulated microwave fields. , 1984, Bioelectromagnetics.

[77]  T. Litovitz,et al.  The role of coherence time in the effect of microwaves on ornithine decarboxylase activity. , 1993, Bioelectromagnetics.

[78]  Fehmi Ozguner,et al.  Biological and morphological effects on the reproductive organ of rats after exposure to electromagnetic field. , 2005, Saudi medical journal.

[79]  Fehmi Ozguner,et al.  Prevention of mobile phone induced skin tissue changes by melatonin in rat: an experimental study , 2004, Toxicology and industrial health.

[80]  I. Belyaev,et al.  Cooperativity in E. coli cell response to resonance effect of weak extremely low frequency electromagnetic field , 1995 .

[81]  K. H. Mild,et al.  Ionizing radiation, cellular telephones and the risk for brain tumours , 2001, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation.

[82]  A. Pál,et al.  IS THERE A RELATIONSHIP BETWEEN CELL PHONE USE AND SEMEN QUALITY? , 2005, Archives of andrology.

[83]  Bertil R. R. Persson,et al.  Blood‐brain barrier permeability in rats exposed to electromagnetic fields used in wireless communication , 1997, Wirel. Networks.

[84]  Kjell Hansson Mild,et al.  Further aspects on cellular and cordless telephones and brain tumours. , 2003, International journal of oncology.

[85]  M. Harms-Ringdahl,et al.  Effects of zero magnetic field on the conformation of chromatin in human cells. , 1997, Biochimica et biophysica acta.

[86]  T. Litovitz,et al.  Chronic electromagnetic field exposure decreases HSP70 levels and lowers cytoprotection , 2002, Journal of cellular biochemistry.

[87]  David W. P. Thomas,et al.  Cell biology: Non-thermal heat-shock response to microwaves , 2000, Nature.

[88]  K. V. Lukashevsky,et al.  SWITCHING OF PROPHAGE LAMBDA GENES IN ESCHERICHIA COLI BY MILLIMETRE WAVES , 1990 .

[89]  I. Belyaev,et al.  Frequency-dependent effects of ELF magnetic field on chromatin conformation in Escherichia coli cells and human lymphocytes. , 2001, Biochimica et biophysica acta.

[90]  Igor Belyaev,et al.  Nonthermal effects of extremely high-frequency microwaves on chromatin conformation in cells in vivo-dependence on physical, physiological, and genetic factors , 2000 .

[91]  Y. Akyel,et al.  Current state and implications of research on biological effects of millimeter waves: a review of the literature. , 1998, Bioelectromagnetics.

[92]  Fehmi Ozguner,et al.  Oxidative damage in the kidney induced by 900-MHz-emitted mobile phone: protection by melatonin. , 2005, Archives of medical research.

[93]  V A Polunin,et al.  Resonance effect of millimeter waves in the power range from 10(-19) to 3 x 10(-3) W/cm2 on Escherichia coli cells at different concentrations. , 1996, Bioelectromagnetics.