Intracellular CHO Cell Metabolite Profiling Reveals Steady‐State Dependent Metabolic Fingerprints in Perfusion Culture
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Massimo Morbidelli | Miroslav Soos | Renato Zenobi | Marie R G Kopp | M. Morbidelli | R. Zenobi | M. Šoóš | Daniel J Karst | Robert F Steinhoff | Elisa Serra | Marie R. G. Kopp | E. Serra | Daniel J. Karst | Robert F. Steinhoff
[1] R. Goodacre,et al. Metabolite profiling of CHO cells: Molecular reflections of bioprocessing effectiveness. , 2015, Biotechnology journal.
[2] R. Goodacre,et al. Metabolite profiling of recombinant CHO cells: designing tailored feeding regimes that enhance recombinant antibody production. , 2011, Biotechnology and bioengineering.
[3] Yao-ming Huang,et al. Perfusion seed cultures improve biopharmaceutical fed‐batch production capacity and product quality , 2014, Biotechnology progress.
[4] Massimo Morbidelli,et al. Characterization and comparison of ATF and TFF in stirred bioreactors for continuous mammalian cell culture processes , 2016 .
[5] Dong-Yup Lee,et al. Metabolomics-driven approach for the improvement of Chinese hamster ovary cell growth: overexpression of malate dehydrogenase II. , 2010, Journal of biotechnology.
[6] I. Gout,et al. Coenzyme A biosynthetic machinery in mammalian cells. , 2014, Biochemical Society transactions.
[7] Konstantin B Konstantinov,et al. White paper on continuous bioprocessing. May 20-21, 2014 Continuous Manufacturing Symposium. , 2015, Journal of pharmaceutical sciences.
[8] Rashmi Kshirsagar,et al. Concentrated fed-batch cell culture increases manufacturing capacity without additional volumetric capacity. , 2016, Journal of biotechnology.
[9] Thomas Ryll,et al. Maximizing productivity of CHO cell‐based fed‐batch culture using chemically defined media conditions and typical manufacturing equipment , 2010, Biotechnology progress.
[10] T. Traut,et al. Physiological concentrations of purines and pyrimidines , 1994, Molecular and Cellular Biochemistry.
[11] M. Butler,et al. Effect of temperature on nucleotide pools and monoclonal antibody production in a mouse hybridoma , 1994, Biotechnology and bioengineering.
[12] Thomas K. Villiger,et al. Evaluating the impact of cell culture process parameters on monoclonal antibody N-glycosylation. , 2014, Journal of biotechnology.
[13] Konstantin Konstantinov,et al. End-to-end integrated fully continuous production of recombinant monoclonal antibodies. , 2015, Journal of biotechnology.
[14] I. Gout,et al. EDC4 interacts with and regulates the dephospho‐CoA kinase activity of CoA synthase , 2012, FEBS letters.
[15] T. Ryll,et al. Improved ion-pair high-performance liquid chromatographic method for the quantification of a wide variety of nucleotides and sugar-nucleotides in animal cells. , 1991, Journal of chromatography.
[16] Dong-Yup Lee,et al. Metabolomics-based identification of apoptosis-inducing metabolites in recombinant fed-batch CHO culture media. , 2011, Journal of biotechnology.
[17] Nathan E Lewis,et al. The emerging CHO systems biology era: harnessing the 'omics revolution for biotechnology. , 2013, Current opinion in biotechnology.
[18] M. Klapa,et al. Metabolic profiling reveals that time related physiological changes in mammalian cell perfusion cultures are bioreactor scale independent. , 2013, Metabolic engineering.
[19] Sen Xu,et al. High-density mammalian cell cultures in stirred-tank bioreactor without external pH control. , 2016, Journal of biotechnology.
[20] Natarajan Vijayasankaran,et al. Understanding the intracellular effect of enhanced nutrient feeding toward high titer antibody production process , 2011, Biotechnology and bioengineering.
[21] J. Goergen,et al. Intracellular nucleotide and nucleotide sugar contents of cultured CHO cells determined by a fast, sensitive, and high-resolution ion-pair RP-HPLC. , 2006, Analytical biochemistry.
[22] Dong-Yup Lee,et al. LC‐MS‐based metabolic characterization of high monoclonal antibody‐producing Chinese hamster ovary cells , 2012, Biotechnology and bioengineering.
[23] D. E. Atkinson. Regulation of enzyme function. , 1969, Annual review of microbiology.
[24] Charles L. Cooney,et al. White Paper on Continuous Bioprocessing , 2014 .
[25] T. Ryll,et al. Intracellular ribonucleotide pools as a tool for monitoring the physiological state of in vitro cultivated mammalian cells during production processes , 1992, Biotechnology and bioengineering.
[26] Nicholas E. Timmins,et al. Metabolite profiling of CHO cells with different growth characteristics , 2012, Biotechnology and bioengineering.
[27] F. Wurm. Production of recombinant protein therapeutics in cultivated mammalian cells , 2004, Nature Biotechnology.
[28] Massimo Morbidelli,et al. High‐throughput nucleoside phosphate monitoring in mammalian cell fed‐batch cultivation using quantitative matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry , 2015, Biotechnology journal.
[29] Niki S. C. Wong,et al. Combined in silico modeling and metabolomics analysis to characterize fed‐batch CHO cell culture , 2012, Biotechnology and bioengineering.
[30] D. Berkich,et al. Rate-limiting step and control of coenzyme A synthesis in cardiac muscle. , 1982, The Journal of biological chemistry.
[31] Massimo Morbidelli,et al. Microarray-based MALDI-TOF mass spectrometry enables monitoring of monoclonal antibody production in batch and perfusion cell cultures. , 2016, Methods.
[32] K. Jefimovs,et al. Self-aliquoting microarray plates for accurate quantitative matrix-assisted laser desorption/ionization mass spectrometry. , 2013, Analytical chemistry.
[33] Chetan T Goudar,et al. Metabolomics for high-resolution monitoring of the cellular physiological state in cell culture engineering. , 2010, Metabolic engineering.
[34] Characterization of intrinsic variability in time‐series metabolomic data of cultured mammalian cells , 2015, Biotechnology and bioengineering.
[35] Michael C. Borys,et al. The use of ‘Omics technology to rationally improve industrial mammalian cell line performance , 2016, Biotechnology and bioengineering.
[36] T. Traut. Allosteric Regulatory Enzymes , 2007 .