Severe asthma in adults: what are the important questions?
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W. Busse | L. Boulet | K. Rabe | M. Humbert | G. Joos | L. Fabbri | Susan J Wilson | S. Dahlén | P. Sterk | S. Holgate | C. Brightling | S. Wenzel | M. Castro | B. Levy | P. Chanez | J. Antó | E. Bel | I. Vachier | M. Gaga | G. Anderson | B. Dahlen | J. Anto | S. Wilson | B. Dahlén
[1] Martyn R Partridge,et al. British Guideline on the Management of Asthma , 2008, Thorax.
[2] I. Rahman,et al. Oxidative stress in asthma and COPD: antioxidants as a therapeutic strategy. , 2006, Pharmacology & therapeutics.
[3] R. Folz,et al. A novel bronchial ring bioassay for the evaluation of small airway smooth muscle function in mice. , 2006, American journal of physiology. Lung cellular and molecular physiology.
[4] S. Dahlén,et al. Bronchial responsiveness to leukotriene D4 is resistant to inhaled fluticasone propionate. , 2006, The Journal of allergy and clinical immunology.
[5] M. Hasegawa,et al. Airflow limitation and airway dimensions in chronic obstructive pulmonary disease. , 2006, American journal of respiratory and critical care medicine.
[6] K. Lødrup Carlsen,et al. Soluble CD14 at 2 yr of age: Gender‐related effects of tobacco smoke exposure, recurrent infections and atopic diseases , 2006, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.
[7] W. Cushman,et al. Resistant or Difficult‐to‐Treat Hypertension , 2006, The Journal of Clinical Hypertension.
[8] Deborah Jarvis,et al. Prognostic factors of asthma severity: a 9-year international prospective cohort study. , 2006, The Journal of allergy and clinical immunology.
[9] S. Johnston. Macrolide antibiotics and asthma treatment. , 2006, The Journal of allergy and clinical immunology.
[10] I. Buchan,et al. Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials. , 2006, JAMA.
[11] E. Bel. "Hot stuff": bronchial thermoplasty for asthma. , 2006, American journal of respiratory and critical care medicine.
[12] A. McWilliams,et al. Bronchial thermoplasty for asthma. , 2006, American journal of respiratory and critical care medicine.
[13] K. Rabe,et al. Alveolar nitric oxide versus measures of peripheral airway dysfunction in severe asthma , 2006, European Respiratory Journal.
[14] Choon-Sik Park,et al. A disintegrin and metalloproteinase 33 protein in patients with asthma: Relevance to airflow limitation. , 2006, American journal of respiratory and critical care medicine.
[15] Vernon M. Chinchilli,et al. β-Adrenergic Receptor Polymorphisms and Response to Salmeterol , 2006 .
[16] L. Boulet,et al. Determining asthma treatment by monitoring sputum cell counts: effect on exacerbations , 2006, European Respiratory Journal.
[17] I. Adcock,et al. Update on glucocorticoid action and resistance. , 2006, The Journal of allergy and clinical immunology.
[18] S. Wenzel,et al. Managing severe asthma. , 2006, The Journal of allergy and clinical immunology.
[19] I. Pavord,et al. Evidence of a role of tumor necrosis factor alpha in refractory asthma. , 2006, The New England journal of medicine.
[20] W. Busse,et al. 6. Asthma: Factors underlying inception, exacerbation, and disease progression , 2006, Journal of Allergy and Clinical Immunology.
[21] M. Everard. The relationship between respiratory syncytial virus infections and the development of wheezing and asthma in children , 2006, Current opinion in allergy and clinical immunology.
[22] H. Boushey,et al. Rhinovirus induces airway epithelial gene expression through double-stranded RNA and IFN-dependent pathways. , 2006, American journal of respiratory cell and molecular biology.
[23] I. Adcock,et al. Histone deacetylase 2–mediated deacetylation of the glucocorticoid receptor enables NF-κB suppression , 2006, The Journal of experimental medicine.
[24] S. Wenzel,et al. Gender Differences in IgE-Mediated Allergic Asthma in the Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) Study , 2006, The Journal of asthma : official journal of the Association for the Care of Asthma.
[25] P. Chanez,et al. Are overweight asthmatics more difficult to control? , 2005, Allergy.
[26] A. Woodcock,et al. Study of modifiable risk factors for asthma exacerbations: virus infection and allergen exposure increase the risk of asthma hospital admissions in children , 2005, Thorax.
[27] P. Howarth,et al. Tumour necrosis factor (TNFalpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthma. , 2005, Thorax.
[28] E. Bleecker,et al. Aspirin sensitivity and severity of asthma: evidence for irreversible airway obstruction in patients with severe or difficult-to-treat asthma. , 2005, The Journal of allergy and clinical immunology.
[29] Charles A. Johnson,et al. Severity assessment in asthma: An evolving concept. , 2005, The Journal of allergy and clinical immunology.
[30] A. Zwinderman,et al. Risk factors of frequent exacerbations in difficult-to-treat asthma , 2005, European Respiratory Journal.
[31] J. Cidlowski,et al. Antiinflammatory action of glucocorticoids--new mechanisms for old drugs. , 2005, The New England journal of medicine.
[32] S. Wenzel,et al. Defective apoptotic cell phagocytosis attenuates prostaglandin E2 and 15-hydroxyeicosatetraenoic acid in severe asthma alveolar macrophages. , 2005, American journal of respiratory and critical care medicine.
[33] Carolyn A. Lall,et al. Beneficial and harmful effects of oscillatory mechanical strain on airway smooth muscle. , 2005, Canadian journal of physiology and pharmacology.
[34] L. Palmer,et al. Diminished lipoxin biosynthesis in severe asthma. , 2005, American journal of respiratory and critical care medicine.
[35] W. Hop,et al. Titrating steroids on exhaled nitric oxide in children with asthma: a randomized controlled trial. , 2005, American journal of respiratory and critical care medicine.
[36] J. Uddin,et al. Design, synthesis and bioactions of novel stable mimetics of lipoxins and aspirin-triggered lipoxins. , 2005, Prostaglandins, leukotrienes, and essential fatty acids.
[37] C. Lemière,et al. Differences in airway remodeling between subjects with severe and moderate asthma. , 2005, The Journal of allergy and clinical immunology.
[38] R. Scott,et al. Differential proteolytic enzyme activity in eosinophilic and neutrophilic asthma. , 2005, American journal of respiratory and critical care medicine.
[39] L. Borish,et al. Total serum IgE levels in a large cohort of patients with severe or difficult-to-treat asthma. , 2005, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
[40] P. Gibson,et al. Interleukin-10 gene expression in acute virus-induced asthma. , 2005, American journal of respiratory and critical care medicine.
[41] J. Malo. Asthma may be more severe if it is work-related. , 2005, American journal of respiratory and critical care medicine.
[42] P. Thompson,et al. Plasma concentrations of dietary and nondietary antioxidants are low in severe asthma , 2005, European Respiratory Journal.
[43] P. Sly,et al. Lyn-Deficient Mice Develop Severe, Persistent Asthma: Lyn Is a Critical Negative Regulator of Th2 Immunity 1 , 2005, The Journal of Immunology.
[44] J. Cowan,et al. Use of exhaled nitric oxide measurements to guide treatment in chronic asthma. , 2005, The New England journal of medicine.
[45] L. Boulet,et al. Patterns and determinants of compliance with inhaled steroids in adults with asthma. , 2005, Canadian respiratory journal.
[46] E. Cook,et al. Relationships among quality of life, severity, and control measures in asthma: an evaluation using factor analysis. , 2005, The Journal of allergy and clinical immunology.
[47] E. Ford. Current reviews of allergy and clinical immunology , 2005 .
[48] J Bousquet,et al. Benefits of omalizumab as add‐on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE , 2005, Allergy.
[49] R. Poulton,et al. Sex differences in the relation between body mass index and asthma and atopy in a birth cohort. , 2005, American journal of respiratory and critical care medicine.
[50] S. Wenzel,et al. Increased TGF-β2 in severe asthma with eosinophilia , 2005 .
[51] J. Bousquet,et al. Severe asthma is associated with a loss of LX4, an endogenous anti-inflammatory compound. , 2005, The Journal of allergy and clinical immunology.
[52] N. Thomson,et al. Asthma and cigarette smoking , 2004, European Respiratory Journal.
[53] E. Israel,et al. Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial , 2004, The Lancet.
[54] L. Grinberg,et al. Abnormal alveolar attachments with decreased elastic fiber content in distal lung in fatal asthma. , 2004, American journal of respiratory and critical care medicine.
[55] N. Zamel,et al. Effect of Fluticasone/Salmeterol and Monteleukast on Total Exhaled, Bronchial, and Alveolar Nitric Oxide in Asthmatics , 2004 .
[56] S. Wenzel,et al. Transforming growth factor-beta2 induces bronchial epithelial mucin expression in asthma. , 2004, The American journal of pathology.
[57] N. Zamel,et al. Risk factors for near-fatal asthma. , 2004, Chest.
[58] A. Zwinderman,et al. "Refractory" eosinophilic airway inflammation in severe asthma: effect of parenteral corticosteroids. , 2004, American journal of respiratory and critical care medicine.
[59] M. Bihl,et al. Dysfunctional interaction of C/EBPalpha and the glucocorticoid receptor in asthmatic bronchial smooth-muscle cells. , 2004, The New England journal of medicine.
[60] M. Sanak,et al. Functional effects and gender association of COX-2 gene polymorphism G-765C in bronchial asthma. , 2004, The Journal of allergy and clinical immunology.
[61] Anticholinergic agents for chronic asthma in adults. , 2004, The Cochrane database of systematic reviews.
[62] I. Adcock,et al. Histone acetylase and deacetylase activity in alveolar macrophages and blood mononocytes in asthma. , 2004, American journal of respiratory and critical care medicine.
[63] S. Gabriel,et al. Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids. , 2004, Human molecular genetics.
[64] D. Postma,et al. Polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in asthma , 2004, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
[65] S. Tsiodras,et al. Clarithromycin reduces the severity of bronchial hyperresponsiveness in patients with asthma , 2004, European Respiratory Journal.
[66] S. Shore,et al. Obesity and asthma: directions for research. , 2004, American journal of respiratory and critical care medicine.
[67] J. Bousquet,et al. Efficacy and safety of a recombinant anti‐immunoglobulin E antibody (omalizumab) in severe allergic asthma , 2004, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
[68] J. Fredberg. Bronchospasm and its biophysical basis in airway smooth muscle , 2004, Respiratory research.
[69] E. Silverman,et al. Asthma steroid pharmacogenetics: a study strategy to identify replicated treatment responses. , 2004, Proceedings of the American Thoracic Society.
[70] P. Barnes. Corticosteroid resistance in airway disease. , 2004, Proceedings of the American Thoracic Society.
[71] I. Adcock,et al. Glucocorticoids: effects on gene transcription. , 2004, Proceedings of the American Thoracic Society.
[72] S. Wenzel,et al. Distinguishing severe asthma phenotypes: role of age at onset and eosinophilic inflammation. , 2004, The Journal of allergy and clinical immunology.
[73] E. Bel. Clinical phenotypes of asthma. , 2004, Current opinion in pulmonary medicine.
[74] A. Custovic,et al. Allergens, viruses, and asthma exacerbations. , 2004, Proceedings of the American Thoracic Society.
[75] P. Gibson,et al. Azoles for allergic bronchopulmonary aspergillosis associated with asthma. , 2004, The Cochrane database of systematic reviews.
[76] J. Bousquet,et al. High levels of urinary leukotriene E4 excretion in steroid treated patients with severe asthma. , 2003, Respiratory medicine.
[77] D. Postma,et al. The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma , 2003, European Respiratory Journal.
[78] J. Bousquet,et al. Glucocorticoid receptor-binding characteristics in severe asthma , 2003, European Respiratory Journal.
[79] S. Dahlén,et al. Biochemical and clinical evidence that aspirin-intolerant asthmatic subjects tolerate the cyclooxygenase 2-selective analgetic drug celecoxib. , 2003, The Journal of allergy and clinical immunology.
[80] S. Wenzel. Severe asthma: epidemiology, pathophysiology and treatment. , 2003, The Mount Sinai journal of medicine, New York.
[81] I. Sayers,et al. Inhaled corticosteroids and long acting β2 agonists can help patients with COPD , 2003, Thorax.
[82] R. Djukanović,et al. The role of the epidermal growth factor receptor in sustaining neutrophil inflammation in severe asthma , 2003, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
[83] F. Ricciardolo,et al. Multiple roles of nitric oxide in the airways , 2003, Thorax.
[84] P. Gibson,et al. Gastro-oesophageal reflux treatment for asthma in adults and children. , 2003, The Cochrane database of systematic reviews.
[85] T. Casale,et al. Omalizumab, a recombinant humanized anti-IgE antibody, reduces asthma-related emergency room visits and hospitalizations in patients with allergic asthma. , 2003, The Journal of allergy and clinical immunology.
[86] P. Howarth,et al. Increased expression of p21(waf) cyclin-dependent kinase inhibitor in asthmatic bronchial epithelium. , 2003, American journal of respiratory cell and molecular biology.
[87] I. Pavord,et al. Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial , 2002, The Lancet.
[88] I. Pavord,et al. Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids , 2002, Thorax.
[89] A. James,et al. Increased mast cells and neutrophils in submucosal mucous glands and mucus plugging in patients with asthma , 2002, Thorax.
[90] Richard J Martin,et al. Mycoplasma pneumoniae and Chlamydia pneumoniae in asthma: effect of clarithromycin. , 2002, Chest.
[91] I. Pavord,et al. Mast-cell infiltration of airway smooth muscle in asthma. , 2002, The New England journal of medicine.
[92] A. James,et al. Distribution and degranulation of airway mast cells in normal and asthmatic subjects , 2002, European Respiratory Journal.
[93] Christopher E Brightling,et al. A comparison of the validity of different diagnostic tests in adults with asthma. , 2002, Chest.
[94] P Godard,et al. Costs of asthma are correlated with severity: a 1-yr prospective study , 2002, European Respiratory Journal.
[95] P. Gibson,et al. Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma , 2002, European Respiratory Journal.
[96] R. Pauwels,et al. Improvement of aspirin-intolerant asthma by montelukast, a leukotriene antagonist: a randomized, double-blind, placebo-controlled trial. , 2002, American journal of respiratory and critical care medicine.
[97] P. Henricks,et al. Reactive oxygen species as mediators in asthma. , 2001, Pulmonary pharmacology & therapeutics.
[98] I. Adcock,et al. TGFβ1 allele association with asthma severity , 2001, Human Genetics.
[99] W. Busse,et al. Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma. , 2001, The Journal of allergy and clinical immunology.
[100] R. Townley,et al. The anti-IgE antibody omalizumab reduces exacerbations and steroid requirement in allergic asthmatics. , 2001, The European respiratory journal.
[101] P. Barnes,et al. Addition of leukotriene antagonists to therapy in chronic persistent asthma: a randomised double-blind placebo-controlled trial , 2001, The Lancet.
[102] L. Boulet,et al. Evaluation of two different educational interventions for adult patients consulting with an acute asthma exacerbation. , 2001, American journal of respiratory and critical care medicine.
[103] P. Gibson,et al. Heterogeneity of airway inflammation in persistent asthma : evidence of neutrophilic inflammation and increased sputum interleukin-8. , 2001, Chest.
[104] A. Zwinderman,et al. Persistent airflow limitation in adult-onset nonatopic asthma is associated with serologic evidence of Chlamydia pneumoniae infection. , 2001, The Journal of allergy and clinical immunology.
[105] E. Bel,et al. Similar psychological characteristics in mild and severe asthma. , 2001, Journal of psychosomatic research.
[106] C. Lemière,et al. Persistent specific bronchial reactivity to occupational agents in workers with normal nonspecific bronchial reactivity. , 2000, American journal of respiratory and critical care medicine.
[107] J. Virchow,et al. Zafirlukast improves asthma control in patients receiving high-dose inhaled corticosteroids. , 2000, American journal of respiratory and critical care medicine.
[108] C. Jenkins,et al. Optimal asthma control, starting with high doses of inhaled budesonide. , 2000, The European respiratory journal.
[109] J. Spinelli,et al. Polymorphisms in the IL4, IL4RA, and FCERIB genes and asthma severity. , 2000, The Journal of allergy and clinical immunology.
[110] P. Howarth,et al. Involvement of the epidermal growth factor receptor in epithelial repair in asthma , 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[111] M. Kraft,et al. The role of bacterial infections in asthma. , 2000, Clinics in chest medicine.
[112] G. Joos,et al. Role of tachykinins in asthma , 2000, Allergy.
[113] S. Spector,et al. Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions. American Thoracic Society. , 2000, American journal of respiratory and critical care medicine.
[114] G H Guyatt,et al. Development and validation of a questionnaire to measure asthma control. , 1999, The European respiratory journal.
[115] D. Postma,et al. Difficult/therapy-resistant asthma: the need for an integrated approach to define clinical phenotypes, evaluate risk factors, understand pathophysiology and find novel therapies. ERS Task Force on Difficult/Therapy-Resistant Asthma. European Respiratory Society. , 1999, The European respiratory journal.
[116] Third Expert Panel on theDiagnosis,et al. Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma , 1997 .
[117] R. Pauwels,et al. GLOBAL STRATEGY FOR ASTHMA MANAGEMENT AND PREVENTION , 1996 .