Bet v 1‐like pollen allergens of multiple Fagales species can sensitize atopic individuals

In the temperate climate zone of the Northern hemisphere, Fagales pollen allergy represents the main cause of winter/spring pollinosis. Among Fagales trees, pollen allergies are strongly associated within the Betulaceae and the Fagaceae families. It is widely accepted that Fagales pollen allergies are initiated by sensitization against Bet v 1, the birch pollen major allergen, although evidence is accumulating that the allergenic activity of some Bet v 1‐like molecules has been underestimated.

[1]  María Martín,et al.  Ongoing and future developments at the Universal Protein Resource , 2010, Nucleic Acids Res..

[2]  C. Alessandri,et al.  Cross‐sectional survey on immunoglobulin E reactivity in 23 077 subjects using an allergenic molecule‐based microarray detection system , 2010, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[3]  Donald F. Conrad,et al.  A Protein Allergen Microarray Detects Specific IgE to Pollen Surface, Cytoplasmic, and Commercial Allergen Extracts , 2010, PloS one.

[4]  Martin Himly,et al.  Antigen Aggregation Decides the Fate of the Allergic Immune Response , 2009, The Journal of Immunology.

[5]  P. Briza,et al.  The Influence of Recombinant Production on the Immunologic Behavior of Birch Pollen Isoallergens , 2009, PloS one.

[6]  R. Van Ree,et al.  Standardization of allergen products: 1. Detailed characterization of GMP‐produced recombinant Bet v 1.0101 as biological reference preparation , 2009, Allergy.

[7]  P. Briza,et al.  Immunologic characterization of isoforms of Car b 1 and Que a 1, the major hornbeam and oak pollen allergens , 2009, Allergy.

[8]  F. Horak,et al.  The allergen profile of beech and oak pollen , 2008, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[9]  S. Bonini,et al.  Allergenic pollen and pollen allergy in Europe , 2007, Allergy.

[10]  Christian Harwanegg,et al.  Protein microarrays for the diagnosis of allergic diseases: state-of-the-art and future development , 2006, Clinical chemistry and laboratory medicine.

[11]  H. Breiteneder,et al.  Crystal structure of the major celery allergen Api g 1: molecular analysis of cross-reactivity. , 2005, Journal of molecular biology.

[12]  S. Vieths,et al.  Development of a functional in vitro assay as a novel tool for the standardization of allergen extracts in the human system , 2005, Allergy.

[13]  R. Valenta,et al.  Transition from a Botanical to a Molecular Classification in Tree Pollen Allergy: Implications for Diagnosis and Therapy , 2004, International Archives of Allergy and Immunology.

[14]  E. Goormaghtigh,et al.  The optimization of protein secondary structure determination with infrared and circular dichroism spectra. , 2004, European journal of biochemistry.

[15]  D. Soltis,et al.  Phylogenetic Relationships in Fagales Based on DNA Sequences from Three Genomes , 2004, International Journal of Plant Sciences.

[16]  A. Mari,et al.  Fagales pollen sensitization in a birch‐free area: a respiratory cohort survey using Fagales pollen extracts and birch recombinant allergens (rBet v 1, rBet v 2, rBet v 4) , 2003, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[17]  T. Haahtela,et al.  Different IgE Reactivity Profiles in Birch Pollen-Sensitive Patients from Six European Populations Revealed by Recombinant Allergens: An Imprint of Local Sensitization , 2002, International Archives of Allergy and Immunology.

[18]  C. Montanari,et al.  Biochemical and immunochemical characterization of hop-hornbeam (Ostrya Carpinifolia Scop.) pollen , 2000 .

[19]  S. Manchester,et al.  Phylogeny and evolution of the Betulaceae as inferred from DNA sequences, morphology, and paleobotany. , 1999, American journal of botany.

[20]  R. Aalberse,et al.  How far can we simplify in vitro diagnostics for Fagales tree pollen allergy? A study with three whole pollen extracts and purified natural and recombinant allergens , 1999, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[21]  R. Valenta,et al.  Recombinant birch pollen allergens (rBet v 1 and rBet v 2) contain most of the IgE epitopes present in birch, alder, hornbeam, hazel, and oak pollen: a quantitative IgE inhibition study with sera from different populations. , 1998, The Journal of allergy and clinical immunology.

[22]  D. Barber,et al.  Pollinosis due to Australian pine (Casuarina): an aerobiologic and clinical study in southern Spain , 1997, Allergy.

[23]  Flemming M. Poulsen,et al.  X-ray and NMR structure of Bet v 1, the origin of birch pollen allergy , 1996, Nature Structural Biology.

[24]  K. Hoffmann‐Sommergruber,et al.  Purification, characterization and N-terminal amino acid sequence of a new major allergen from European chestnut pollen--Cas s 1. , 1993, Biochemical and biophysical research communications.

[25]  K. Hoffmann‐Sommergruber,et al.  Four recombinant isoforms of Cor a I, the major allergen of hazel pollen, show different IgE-binding properties. , 1993, European journal of biochemistry.

[26]  K. Hoffmann‐Sommergruber,et al.  Complementary DNA cloning and expression in Escherichia coli of Aln g I, the major allergen in pollen of alder (Alnus glutinosa). , 1992, The Journal of allergy and clinical immunology.

[27]  R. Lockey,et al.  Nasal and bronchial provocation challenges with bayberry (Myrica cerifera) pollen extract. , 1992, The Journal of allergy and clinical immunology.

[28]  R. Valenta,et al.  The gene coding for the major birch pollen allergen Betv1, is highly homologous to a pea disease resistance response gene. , 1989, The EMBO journal.

[29]  F. Vuilleumier An atlas of past and Present Pollen Maps for Europe: 0-13000 Years Ago , 1987 .

[30]  S. Bonini,et al.  Allergenic pollen and pollinosis in Europe , 1991 .