ASSOCIATION BETWEEN EARLY-ONSET PARKINSON ’ S DISEASE AND MUTATIONS IN THE PARKIN GENE

C HRISTOPH B. L ÜCKING , M.D., A LEXANDRA D ÜRR , M.D., P H .D., V INCENZO B ONIFATI , M.D., J ENNY V AUGHAN , M.D., G IUSEPPE D E M ICHELE , M.D., T HOMAS G ASSER , M.D., B ISWADJIET S. H ARHANGI , M.D., G IUSEPPE M ECO , M.D., P ATRICE D ENÈFLE , P H .D., N ICHOLAS W. W OOD , M.D., P H .D., Y VES A GID , M.D., P H .D., AND A LEXIS B RICE , M.D., FOR THE E UROPEAN C ONSORTIUM ON G ENETIC S USCEPTIBILITY IN P ARKINSON ’ S D ISEASE

[1]  M. Polymeropoulos,et al.  Deletions in the Parkin gene and genetic heterogeneity in a Greek family with early onset Parkinson’s disease , 1998, Human Genetics.

[2]  N. Shimizu,et al.  Molecular genetic analysis of a novel Parkin gene in Japanese families with autosomal recessive juvenile parkinsonism: Evidence for variable homozygous deletions in the Parkin gene in affected individuals , 1998, Annals of neurology.

[3]  B. Müller-Myhsok,et al.  A susceptibility locus for Parkinson's disease maps to chromosome 2p13 , 1998, Nature Genetics.

[4]  S E Ide,et al.  Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. , 1997, Science.

[5]  Paola Piccini,et al.  The role of inheritance in sporadic Parkinson's disease: Evidence from a longitudinal study of dopaminergic function in twins , 1999, Annals of neurology.

[6]  J. Dartigues,et al.  Prevalence of parkinsonism and Parkinson's disease in Europe: the EUROPARKINSON Collaborative Study. European Community Concerted Action on the Epidemiology of Parkinson's disease. , 1997, Journal of neurology, neurosurgery, and psychiatry.

[7]  S. Tsuji,et al.  Familial juvenile parkinsonism , 1994, Neurology.

[8]  A. Rajput.  Pathologic and biochemical studies of juvenile parkinsonism linked to chromosome 6q. , 1999, Neurology.

[9]  L. Bolund,et al.  Protein misfolding and degradation in genetic diseases , 1999, Human mutation.

[10]  Georg Auburger,et al.  The ubiquitin pathway in Parkinson's disease , 1998, Nature.

[11]  M. Farrer,et al.  A chromosome 4p haplotype segregating with Parkinson's disease and postural tremor. , 1999, Human molecular genetics.

[12]  M. Hoehn,et al.  Parkinsonism , 1967, Neurology.

[13]  Y. Agid,et al.  A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. French Parkinson's Disease Genetics Study Group and the European Consortium on Genetic Susceptibility in Parkinson's Disease. , 1999, Human molecular genetics.

[14]  P. Bork,et al.  A novel transactivation domain in parkin. , 1999, Trends in biochemical sciences.

[15]  S. Minoshima,et al.  Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism , 1998, Nature.

[16]  A. Parent,et al.  Cloning of Rat Parkin cDNA and Distribution of Parkin in Rat Brain , 2000, Journal of neurochemistry.

[17]  A. Ishikawa,et al.  Clinical analysis of 17 patients in 12 Japanese families with autosomal-recessive type juvenile parkinsonism , 1996, Neurology.

[18]  A. Lees,et al.  Ageing and Parkinson's disease: substantia nigra regional selectivity. , 1991, Brain : a journal of neurology.

[19]  N. Wood.  Genes and parkinsonism. , 1997, Journal of neurology, neurosurgery, and psychiatry.

[20]  Y. Agid,et al.  Homozygous deletions in parkin gene in European and North African families with autosomal recessive juvenile parkinsonism , 1998, The Lancet.

[21]  A. Brookes,et al.  Point mutations (Thr240Arg and Gln311Stop) [correction of Thr240Arg and Ala311Stop] in the Parkin gene. , 1998, Biochemical and biophysical research communications.