Effects of particulate matter (PM(10), PM(2.5) and PM(1)) on the cardiovascular system.

Several studies have demonstrated that exposure to particulate matter (PM) of different size fractions is associated with an increased risk of cardiovascular disease (CVD). In this review, we have taken into consideration the possible correlation between the "short term" and "long term" effects of PM exposure and the onset of CVDs as well as the possible molecular mechanisms by which PM elicits the development of these events. Particularly, it is here underlined that these adverse health effects depend not only on the level of PM concentration in the air but also on its particular internal composition. Furthermore, we have also synthesized the findings gleaned from those few studies indicating that PM produced by tobacco smoke can give rise to cardiovascular injury.

[1]  Annette Peters,et al.  Translocation and potential neurological effects of fine and ultrafine particles a critical update , 2006, Particle and Fibre Toxicology.

[2]  F. Gilliland,et al.  Ambient Air Pollution and Atherosclerosis in Los Angeles , 2004, Environmental health perspectives.

[3]  Folate supplementation and cardiovascular disease. , 2006 .

[4]  M F Hoylaerts,et al.  Passage of intratracheally instilled ultrafine particles from the lung into the systemic circulation in hamster. , 2001, American journal of respiratory and critical care medicine.

[5]  S Nava,et al.  Elemental characterization of PM10, PM2.5 and PM1 in the town of Genoa (Italy). , 2006, Chemosphere.

[6]  R. Burnett,et al.  Effects of particulate and gaseous air pollution on cardiorespiratory hospitalizations. , 1999, Archives of environmental health.

[7]  J. Schwartz,et al.  Air Pollution, Smoking, and Plasma Homocysteine , 2006, Environmental health perspectives.

[8]  W P D LOGAN,et al.  Mortality in the London fog incident, 1952. , 1953, Lancet.

[9]  Ronald W. Williams,et al.  Particulate matter exposure in cars is associated with cardiovascular effects in healthy young men. , 2004, American journal of respiratory and critical care medicine.

[10]  A. Peters,et al.  Respiratory effects are associated with the number of ultrafine particles. , 1997, American journal of respiratory and critical care medicine.

[11]  James L. Repace,et al.  BMC Public Health BioMed Central Research article Air pollution in Boston bars before and after a smoking ban , 2006 .

[12]  Tony Bush,et al.  Chronic Exposure to Outdoor Air Pollution and Markers of Systemic Inflammation , 2009, Epidemiology.

[13]  J. Schwartz,et al.  Short term effects of particulate matter on cause specific mortality: effects of lags and modification by city characteristics , 2005, Occupational and Environmental Medicine.

[14]  A. Peters,et al.  Air Pollution and Inflammation (Interleukin-6, C-Reactive Protein, Fibrinogen) in Myocardial Infarction Survivors , 2007, Environmental health perspectives.

[15]  W. MacNee,et al.  Particulate air pollution and acute health effects , 1995, The Lancet.

[16]  A Plasencia,et al.  Apheis: public health impact of PM10 in 19 European cities , 2004, Journal of Epidemiology and Community Health.

[17]  R. Elton,et al.  Particulate air pollution and the blood , 1999, Thorax.

[18]  Chun-Yuh Yang,et al.  Air pollution and hospital admissions for cardiovascular disease in Taipei, Taiwan. , 2005, Environmental research.

[19]  J. Schwartz,et al.  Effects of exposure to air pollution on blood coagulation , 2007, Journal of thrombosis and haemostasis : JTH.

[20]  W G Kreyling,et al.  Negligible clearance of ultrafine particles retained in healthy and affected human lungs , 2006, European Respiratory Journal.

[21]  D L Davis,et al.  Reassessment of the lethal London fog of 1952: novel indicators of acute and chronic consequences of acute exposure to air pollution. , 2001, Environmental health perspectives.

[22]  W. Cascio,et al.  Exposure to Concentrated Ambient Air Particles Alters Hematologic Indices in Humans , 2003, Inhalation toxicology.

[23]  C. Liau,et al.  Urban air pollution increases plasma fibrinogen and plasminogen activator inhibitor-1 levels in susceptible patients , 2006, European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology.

[24]  R. Burnett,et al.  Cardiovascular Mortality and Long-Term Exposure to Particulate Air Pollution: Epidemiological Evidence of General Pathophysiological Pathways of Disease , 2003, Circulation.

[25]  David C Christiani,et al.  The association of particulate air metal concentrations with heart rate variability. , 2002, Environmental health perspectives.

[26]  R. D. Morris,et al.  Airborne particulates and hospital admissions for cardiovascular disease: a quantitative review of the evidence. , 2001, Environmental health perspectives.

[27]  C. Karagiannidis,et al.  Particulate matter inhalation during hay storing activity induces systemic inflammation and platelet aggregation , 2009, European Journal of Applied Physiology.

[28]  J. Schwartz,et al.  Air pollution and emergency admissions in Boston, MA , 2006, Journal of Epidemiology and Community Health.

[29]  Duanping Liao,et al.  Ambient Particulate Air Pollution and Ectopy—The Environmental Epidemiology of Arrhythmogenesis in Women's Health Initiative Study, 1999–2004 , 2008, Journal of toxicology and environmental health. Part A.

[30]  Benoit Nemery,et al.  Diesel Exhaust Particles in Lung Acutely Enhance Experimental Peripheral Thrombosis , 2003, Circulation.

[31]  Inhalation of Steady‐State Sidestream Smoke From One Cigarette Promotes Arteriosclerotic Plaque Development , 1994, Circulation.

[32]  J. Kaufman,et al.  Association between short term exposure to fine particulate matter and heart rate variability in older subjects with and without heart disease , 2005, Thorax.

[33]  P. Hopke,et al.  Characterization of fine aerosol and its inorganic components at two rural locations in New York State , 2008, Environmental monitoring and assessment.

[34]  W. Kreyling,et al.  Translocation of Inhaled Ultrafine Particles to the Brain , 2004, Inhalation toxicology.

[35]  H. Wichmann,et al.  Elemental composition and sources of fine and ultrafine ambient particles in Erfurt, Germany. , 2003, The Science of the total environment.

[36]  Alan D. Lopez,et al.  Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data , 2006, The Lancet.

[37]  Antonella Zanobetti,et al.  The Effect of Particulate Air Pollution on Emergency Admissions for Myocardial Infarction: A Multicity Case-Crossover Analysis , 2005, Environmental health perspectives.

[38]  David G. Anderson,et al.  Exposure to Concentrated Ambient Particles Does Not Affect Vascular Function in Patients with Coronary Heart Disease , 2008, Environmental health perspectives.

[39]  Lung-Chi Chen,et al.  Effects of Subchronic Exposures to Concentrated Ambient Particles (CAPs) in Mice: V. CAPs Exacerbate Aortic Plaque Development in Hyperlipidemic Mice , 2005, Inhalation toxicology.

[40]  F Forastiere,et al.  Associations of traffic related air pollutants with hospitalisation for first acute myocardial infarction: the HEAPSS study , 2006, Occupational and Environmental Medicine.

[41]  Li-Te Chang,et al.  Association of Heart Rate Variability of the Elderly with Personal Exposure to PM1, PM1–2.5, and PM2.5–10 , 2007, Bulletin of environmental contamination and toxicology.

[42]  J. Hogg,et al.  Interaction of alveolar macrophages and airway epithelial cells following exposure to particulate matter produces mediators that stimulate the bone marrow. , 2002, American journal of respiratory cell and molecular biology.

[43]  J. Hogg,et al.  Phagocytosis of small carbon particles (PM10) by alveolar macrophages stimulates the release of polymorphonuclear leukocytes from bone marrow. , 1997, American journal of respiratory and critical care medicine.

[44]  J. Miranda,et al.  Proinflammatory and cytotoxic effects of Mexico City air pollution particulate matter in vitro are dependent on particle size and composition. , 2003, Environmental health perspectives.

[45]  V. Salomaa,et al.  Associations of Fine and Ultrafine Particulate Air Pollution With Stroke Mortality in an Area of Low Air Pollution Levels , 2007, Stroke.

[46]  J. Schwartz,et al.  The temporal pattern of respiratory and heart disease mortality in response to air pollution. , 2003, Environmental health perspectives.

[47]  J Schwartz,et al.  Air pollution and daily mortality in seven major cities of Korea, 1991-1997. , 2000, Environmental research.

[48]  P. Dias,et al.  Influences of the weather and air pollutants on cardiovascular disease in the metropolitan area of São Paulo. , 2007, Environmental research.

[49]  S. Nardini,et al.  A survey on policies of smoking control in Italian hospitals. , 2003, Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace.

[50]  J. Samet,et al.  Air Pollution and Cardiovascular Disease: A Statement for Healthcare Professionals From the Expert Panel on Population and Prevention Science of the American Heart Association , 2004, Circulation.

[51]  W. MacNee,et al.  Role of inflammation in cardiopulmonary health effects of PM. , 2005, Toxicology and Applied Pharmacology.

[52]  A. Peters,et al.  Exposure to traffic and the onset of myocardial infarction. , 2004, The New England journal of medicine.

[53]  P. Maccallum Markers of hemostasis and systemic inflammation in heart disease and atherosclerosis in smokers. , 2005, Proceedings of the American Thoracic Society.

[54]  D. Levy,et al.  Prediction of coronary heart disease using risk factor categories. , 1998, Circulation.

[55]  N. Englert Fine particles and human health--a review of epidemiological studies. , 2004, Toxicology letters.

[56]  C. Sioutas,et al.  Circulating Biomarkers of Inflammation, Antioxidant Activity, and Platelet Activation Are Associated with Primary Combustion Aerosols in Subjects with Coronary Artery Disease , 2008, Environmental health perspectives.

[57]  W. MacNee,et al.  Adenoviral E1A primes alveolar epithelial cells to PM(10)-induced transcription of interleukin-8. , 2001, American journal of physiology. Lung cellular and molecular physiology.

[58]  L. Sheppard,et al.  Long-term exposure to air pollution and incidence of cardiovascular events in women. , 2007, The New England journal of medicine.

[59]  Xavier Querol,et al.  Comparative PM10-PM2.5 source contribution study at rural, urban and industrial sites during PM episodes in Eastern Spain. , 2004, The Science of the total environment.

[60]  I. Shapira,et al.  Short-term exposure to air pollution and inflammation-sensitive biomarkers. , 2008, Environmental research.

[61]  J Schwartz,et al.  Short-term effects of particulate air pollution on cardiovascular diseases in eight European cities , 2002, Journal of epidemiology and community health.

[62]  J. Schwartz,et al.  Exposure to particulate air pollution and risk of deep vein thrombosis. , 2008, Archives of internal medicine.

[63]  R Boffi,et al.  Particulate matter from tobacco versus diesel car exhaust: an educational perspective , 2004, Tobacco Control.

[64]  F. Ballester,et al.  Air pollution and cardiovascular admissions association in Spain: results within the EMECAS project , 2006, Journal of Epidemiology and Community Health.

[65]  Klaus Mann,et al.  Residential Exposure to Traffic Is Associated With Coronary Atherosclerosis , 2007, Circulation.

[66]  F. Dominici,et al.  Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases. , 2006, JAMA.

[67]  Rebecca Hubbard,et al.  A community study of the effect of particulate matter on blood measures of inflammation and thrombosis in an elderly population , 2007, Environmental health : a global access science source.

[68]  W. Mcdonnell,et al.  Long-term inhalable particles and other air pollutants related to mortality in nonsmokers. , 1999, American journal of respiratory and critical care medicine.

[69]  L. Sheppard,et al.  Coagulation markers in healthy human subjects exposed to diesel exhaust. , 2007, Thrombosis research.

[70]  N. Pirrone,et al.  Particle Size Distributions and Elemental Composition of Atmospheric Particulate Matter in Southern Italy , 2008, Journal of the Air & Waste Management Association.

[71]  M. Khazaei,et al.  The pharmacology of particulate matter air pollution-induced cardiovascular dysfunction. , 2007, Pharmacology & therapeutics.

[72]  S. Grambow,et al.  Seasonal Variations in Air Pollution Particle-Induced Inflammatory Mediator Release and Oxidative Stress , 2005, Environmental health perspectives.

[73]  Wolfgang Kreyling,et al.  Ultrafine Particles Exert Prothrombotic but Not Inflammatory Effects on the Hepatic Microcirculation in Healthy Mice In Vivo , 2004, Circulation.

[74]  P. Whincup,et al.  Associations between cigarette smoking, pipe/cigar smoking, and smoking cessation, and haemostatic and inflammatory markers for cardiovascular disease. , 2005, European heart journal.

[75]  F. Dominici,et al.  Potential Confounding of Particulate Matter on the Short-Term Association between Ozone and Mortality in Multisite Time-Series Studies , 2007, Environmental health perspectives.

[76]  A. Peters,et al.  Ambient Air Pollution Is Associated With Increased Risk of Hospital Cardiac Readmissions of Myocardial Infarction Survivors in Five European Cities , 2005, Circulation.

[77]  J. Hogg,et al.  Phagocytosis of particulate air pollutants by human alveolar macrophages stimulates the bone marrow. , 2000, American journal of physiology. Lung cellular and molecular physiology.

[78]  S. Allender,et al.  Cardiovascular disease in Europe , 2009, European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology.

[79]  W. Mitzner,et al.  Exposure to inhaled particulate matter impairs cardiac function in senescent mice. , 2008, American journal of physiology. Regulatory, integrative and comparative physiology.

[80]  Hiroshi Ishii,et al.  Alveolar macrophage-epithelial cell interaction following exposure to atmospheric particles induces the release of mediators involved in monocyte mobilization and recruitment , 2005, Respiratory research.

[81]  W. Cascio,et al.  Effect of ambient particulate matter exposure on hemostasis. , 2007, Translational research : the journal of laboratory and clinical medicine.

[82]  L. Mortelmans,et al.  Passage of Inhaled Particles Into the Blood Circulation in Humans , 2002, Circulation.

[83]  W. Lawrence Beeson,et al.  The Association between Fatal Coronary Heart Disease and Ambient Particulate Air Pollution: Are Females at Greater Risk? , 2005, Environmental health perspectives.

[84]  G. Oberdörster,et al.  Translocation and effects of ultrafine particles outside of the lung. , 2006, Clinics in occupational and environmental medicine.

[85]  R. Brook,et al.  Acute Blood Pressure Responses in Healthy Adults During Controlled Air Pollution Exposures , 2005, Environmental health perspectives.

[86]  M Greaves,et al.  The procoagulant potential of environmental particles (PM10) , 2005, Occupational and Environmental Medicine.

[87]  Gerhard Scheuch,et al.  Deposition, retention, and translocation of ultrafine particles from the central airways and lung periphery. , 2008, American journal of respiratory and critical care medicine.

[88]  R. Haining,et al.  Outdoor air pollution, mortality, and hospital admissions from coronary heart disease in Sheffield, UK: a small-area level ecological study. , 2005, European heart journal.

[89]  Judith C Chow,et al.  Chemical composition of PM2.5 and PM10 in Mexico City during winter 1997. , 2002, The Science of the total environment.

[90]  J. Schwartz,et al.  Reduction in fine particulate air pollution and mortality: Extended follow-up of the Harvard Six Cities study. , 2006, American journal of respiratory and critical care medicine.

[91]  J. Hogg,et al.  The effect of repeated exposure to particulate air pollution (PM10) on the bone marrow. , 2001, American journal of respiratory and critical care medicine.

[92]  David C Christiani,et al.  PM2.5 metal exposures and nocturnal heart rate variability: a panel study of boilermaker construction workers , 2008, Environmental health : a global access science source.

[93]  J. Loscalzo,et al.  Homocysteine and atherothrombosis. , 1998, The New England journal of medicine.

[94]  J. Hogg,et al.  Particulate air pollution induces progression of atherosclerosis. , 2002, Journal of the American College of Cardiology.

[95]  T. Sandström,et al.  Ischemic and thrombotic effects of dilute diesel-exhaust inhalation in men with coronary heart disease. , 2007, The New England journal of medicine.

[96]  W. Cascio,et al.  Ultrafine particulate matter exposure augments ischemia reperfusion injury in mice , 2006, American journal of physiology. Heart and circulatory physiology.

[97]  Scott L. Zeger,et al.  Spatial and Temporal Variation in PM2.5 Chemical Composition in the United States for Health Effects Studies , 2007, Environmental health perspectives.

[98]  Robert D Brook,et al.  Cardiovascular effects of air pollution. , 2008, Clinical science.

[99]  M. Virtanen,et al.  Mortality and air pollution in Helsinki. , 1998, Archives of environmental health.

[100]  Noah Nd,et al.  Letter: Meningococcal infections. , 1975 .

[101]  Joel Schwartz,et al.  Air Pollution and Hospital Admissions for Ischemic and Hemorrhagic Stroke Among Medicare Beneficiaries , 2005, Stroke.

[102]  R. Doll,et al.  Mortality in relation to alcohol consumption: a prospective study among male British doctors. , 2004, International journal of epidemiology.

[103]  J. Hogg,et al.  Particulate matter air pollution stimulates monocyte release from the bone marrow. , 2004, American journal of respiratory and critical care medicine.

[104]  C. Pope,et al.  Ischemic Heart Disease Events Triggered by Short-Term Exposure to Fine Particulate Air Pollution , 2006, Circulation.

[105]  J. Dartigues,et al.  Effects of particulate air pollution on systolic blood pressure: A population-based approach. , 2006, Environmental research.

[106]  B. Brunekreef,et al.  Air pollution and mortality in the Netherlands: are the elderly more at risk? , 2003, European Respiratory Journal.

[107]  J. Hogg,et al.  Particulate matter induces cytokine expression in human bronchial epithelial cells. , 2001, American journal of respiratory cell and molecular biology.

[108]  J. Hogg,et al.  Particulate matter air pollution exposure promotes recruitment of monocytes into atherosclerotic plaques. , 2008, American journal of physiology. Heart and circulatory physiology.

[109]  S. Ebrahim,et al.  Folate supplementation and cardiovascular disease , 2005, The Lancet.

[110]  B. Nemery,et al.  The Meuse Valley fog of 1930: an air pollution disaster , 2001, The Lancet.

[111]  Ronald W. Williams,et al.  Daily variation of particulate air pollution and poor cardiac autonomic control in the elderly. , 1999, Environmental health perspectives.

[112]  J. Hogg,et al.  Contribution of IL-1β and TNF-α to the initiation of the peripheral lung response to atmospheric particulates (PM10) , 2004 .

[113]  Chang-Chuan Chan,et al.  The effect of urban air pollution on inflammation, oxidative stress, coagulation, and autonomic dysfunction in young adults. , 2007, American journal of respiratory and critical care medicine.

[114]  J. Sznajder,et al.  Ambient particulate matter accelerates coagulation via an IL-6-dependent pathway. , 2007, The Journal of clinical investigation.

[115]  H. Kan,et al.  Season, Sex, Age, and Education as Modifiers of the Effects of Outdoor Air Pollution on Daily Mortality in Shanghai, China: The Public Health and Air Pollution in Asia (PAPA) Study , 2008, Environmental health perspectives.

[116]  Antonella Zanobetti,et al.  Ambient Pollution and Blood Pressure in Cardiac Rehabilitation Patients , 2004, Circulation.

[117]  R. Haining,et al.  Outdoor Air Pollution and Stroke in Sheffield, United Kingdom: A Small-Area Level Geographical Study , 2005, Stroke.

[118]  D. Hatsukami,et al.  Effects of cigarette reduction on cardiovascular risk factors and subjective measures. , 2005, Chest.

[119]  W. Cascio,et al.  Altered Heart-Rate Variability in Asthmatic and Healthy Volunteers Exposed to Concentrated Ambient Coarse Particles , 2004, Inhalation toxicology.

[120]  Alireza Afshari,et al.  Indoor particles affect vascular function in the aged: an air filtration-based intervention study. , 2008, American journal of respiratory and critical care medicine.

[121]  J Schwartz,et al.  Oxygen saturation, pulse rate, and particulate air pollution: A daily time-series panel study. , 1999, American journal of respiratory and critical care medicine.

[122]  P. Vinzents,et al.  Exposure to ambient concentrations of particulate air pollution does not influence vascular function or inflammatory pathways in young healthy individuals , 2008, Particle and Fibre Toxicology.

[123]  Alexandra Schneider,et al.  Air pollution and markers of inflammation and coagulation in patients with coronary heart disease. , 2006, American journal of respiratory and critical care medicine.

[124]  W. Kreyling,et al.  Ultrafine particle-lung interactions: does size matter? , 2006, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

[125]  Paul Switzer,et al.  Air change rates of motor vehicles and in-vehicle pollutant concentrations from secondhand smoke , 2008, Journal of Exposure Science and Environmental Epidemiology.

[126]  Ioanna Tzoulaki,et al.  C-Reactive Protein, Interleukin-6, and Soluble Adhesion Molecules as Predictors of Progressive Peripheral Atherosclerosis in the General Population: Edinburgh Artery Study , 2005, Circulation.

[127]  M F Hoylaerts,et al.  Ambient air pollution and acute myocardial infarction , 2005, Journal of thrombosis and haemostasis : JTH.

[128]  G. Esposito,et al.  Characterisation of gaseous and particulate atmospheric pollutants in the East Mediterranean by diffusion denuder sampling lines , 2009, Environmental monitoring and assessment.

[129]  W. Heger,et al.  Consumer exposure to biocides - identification of relevant sources and evaluation of possible health effects , 2010, Environmental health : a global access science source.

[130]  R. D'Agostino,et al.  Concept and usefulness of cardiovascular risk profiles. , 2004, American heart journal.

[131]  Magnus Svartengren,et al.  No Significant Translocation of Inhaled 35-nm Carbon Particles to the Circulation in Humans , 2006, Inhalation toxicology.