Primary cutaneous melanoma. Identification of prognostic groups and estimation of individual prognosis for 5093 patients

Background. Numerous investigations have examined prognostic factors for patients with primary cutaneous melanoma. However, only a few studies have been published on the definition of prognostic groups. The first aim of the present study was to determine the relative importance of different prognostic factors in a large collective study. The second aim was to define prognostic groups of patients based on combinations of prognostic factors and to define a model that allows the estimation of individual survival probability.

[1]  A Morabito,et al.  Prognostic factors and risk groups: some results given by using an algorithm suitable for censored survival data. , 1983, Statistics in medicine.

[2]  C. Karakousis,et al.  Tumor thickness and prognosis in clinical stage I malignant melanoma , 1989, Cancer.

[3]  David R. Cox,et al.  Regression models and life tables (with discussion , 1972 .

[4]  P. C. Hughes.  UICC TNM-Atlas. Illustrated guide to the TNM/pTNN Classification of Malignant Tumours. Second Edition , 1987 .

[5]  F. Weidner.  8-year-survival in malignant melanoma related to sex and tumor location. , 1981, Dermatologica.

[6]  O. Braun-falco,et al.  Prognostic index in malignant melanoma. , 1978, Archives of dermatology.

[7]  C. Garbe,et al.  Epidemiology of malignant melanoma in central Europe: risk factors and prognostic predictors. Results of the Central Malignant Melanoma Registry of the German Dermatological Society. , 2008, Pigment cell research.

[8]  C. Balch,et al.  The prognostic significance of ulceration of cutaneous melanoma , 1980, Cancer.

[9]  D. Reintgen,et al.  Sex related survival differences in instances of melanoma. , 1984, Surgery, gynecology & obstetrics.

[10]  M. Mihm,et al.  The natural break points for primary-tumor thickness in clinical Stage I melanoma. , 1981, The New England journal of medicine.

[11]  N. Cascinelli,et al.  Prognostic factors for stage I melanoma of the skin: a review. , 1985, Statistics in medicine.

[12]  A Breslow,et al.  Thickness, Cross‐Sectional Areas and Depth of Invasion in the Prognosis of Cutaneous Melanoma , 1970, Annals of surgery.

[13]  V. McGovern,et al.  Prognostic significance of the histological features of malignant melanoma , 1979, Histopathology.

[14]  M. Mihm,et al.  A multivariate analysis of prognostic factors for melanoma patients with lesions greater than or equal to 3.65 mm in thickness. The importance of revealing alternative Cox models. , 1982, Annals of surgery.

[15]  E. Kaplan,et al.  Nonparametric Estimation from Incomplete Observations , 1958 .

[16]  C. Balch,et al.  A Multifactorial Analysis of Melanoma: Prognostic Histopathological Features Comparing Clark's and Breslow's Staging Methods , 1978, Annals of surgery.

[17]  R. Lafrenière,et al.  Influence of level and depth on recurrence rate in thin melanomas. , 1993, American journal of surgery.

[18]  Leo Breiman,et al.  Classification and Regression Trees , 1984 .

[19]  H. Adami,et al.  Cutaneous malignant melanoma of the head and neck. Analysis of treatment results and prognostic factors in 581 patients: A report from the swedish melanoma study group , 1993, Cancer.

[20]  A. Kopf,et al.  Influence of anatomic location on prognosis of malignant melanoma: attempt to verify the BANS model. , 1986, Journal of the American Academy of Dermatology.

[21]  S. Fisher.  Cutaneous malignant melanoma of the head and neck , 1989, The Laryngoscope.

[22]  M. Mihm,et al.  Prognostic Factors for Patients with Clinical Stage I Melanoma of Intermediate Thickness (1.51–3.99 mm)* A Conceptual Model for Tumor Growth and Metastasis , 1982 .

[23]  C. Balch,et al.  Tumor thickness as a guide to surgical management of clinical stage I melanoma patients , 1979, Cancer.

[24]  M. Mihm,et al.  A Prognostic Model for Clinical Stage I Melanoma of the Upper Extremity. The Importance of Anatomic Subsites in Predicting Recurrent Disease , 1981, Annals of surgery.

[25]  A. Kopf,et al.  Influence of gender on survival in patients with stage I malignant melanoma. , 1992, Journal of the American Academy of Dermatology.

[26]  M. Weinstock,et al.  Effect of BANS location on the prognosis of clinical stage I melanoma: new data and meta‐analysis , 1988, The British journal of dermatology.

[27]  N. Mantel.  Evaluation of survival data and two new rank order statistics arising in its consideration. , 1966, Cancer chemotherapy reports.

[28]  O. Braun-falco,et al.  Low- and high-risk malignant melanoma--I. Evaluation of clinical and histological prognosticators in 585 cases. , 1983, European journal of cancer & clinical oncology.

[29]  M. Mihm,et al.  Prognosis of clinical stage I melanoma patients with positive elective regional node dissection. , 1986, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[30]  V. McGovern,et al.  Histologic features of tumors and the female superiority in survival from malignant melanoma , 1980, Cancer.

[31]  F. Meyskens,et al.  Cutaneous malignant melanoma (arizona cancer center experience). I. Natural history and prognostic factors influencing survival in patients with stage i disease , 1988, Cancer.

[32]  J. Kalbfleisch,et al.  The Statistical Analysis of Failure Time Data , 1980 .

[33]  W. Clark,et al.  The histogenesis and biologic behavior of primary human malignant melanomas of the skin. , 1969, Cancer research.

[34]  Institut Gustave Roussy,et al.  Prognosis of stage I melanoma of the skin. Who collaborating centres for evaluation of methods of diagnosis and treatment of melanoma , 1980, International journal of cancer.

[35]  M. Mihm,et al.  Prognostic Factors for Melanoma Patients with Lesions 0.76–1.69 mm in Thickness An Appraisal of “Thin” Level IV Lesions , 1982, Annals of surgery.

[36]  O. Braun-falco,et al.  Low- and high-risk malignant melanoma--II. Multivariate analyses for a prognostic classification. , 1983, European journal of cancer & clinical oncology.

[37]  A. Kopf,et al.  Effect of anatomical location on prognosis in patients with clinical stage I melanoma. , 1983, Archives of dermatology.

[38]  D L Morton,et al.  Multivariate analysis of the relationship between survival and the microstage of primary melanoma by clark level and breslow thickness , 1993, Cancer.