A pilot study of Fourier-domain optical coherence tomography of retinal dystrophy patients.

PURPOSE To characterize the macular anatomy of retinal dystrophy eyes using high-speed, high-resolution, Fourier-domain optical coherence tomography (FD-OCT). DESIGN Case-control study. METHODS Retinal dystrophy patients and normal age- and gender-matched controls underwent FD-OCT imaging using the RTVue (Optovue Inc., Fremont, California, USA). Vertical and horizontal 8-mm scans of 1024 lines/cross-section were obtained. Based on boundaries manually drawn on computer displays of OCT cross-sections, the thicknesses of the retina, inner retinal layer (IRL), and outer retinal layer (ORL) were averaged over both 5-mm (macular) and 1.5-mm (foveal) regions centered at the fovea. The IRL was the sum of nerve fiber layer (NFL), ganglion cell layer (GCL), and inner plexiform layer (IPL) thicknesses. Total retinal thickness (RT) was measured between the internal limiting membrane (ILM) and the retinal pigment epithelium. ORL thickness was calculated by subtracting IRL thickness from RT. RESULTS Fourteen patients (three retinitis pigmentosa, two cone-rod degeneration, two Stargardt disease, and seven normal controls) underwent FD-OCT imaging. Mean foveal RT was 271.3 +/- 23.3 microm for controls and 158.4 +/- 47.1 microm for retinal dystrophy patients (P < .001). Mean macular RT was 292.8 +/- 8.1 microm for controls and 199.1 +/- 32.6 microm for retinal dystrophy patients (P < .001). Mean macular ORL was 182.9 +/- 4.7 microm for controls and 101.3 +/- 18.7 microm for retinal dystrophy patients (P < .001); mean macular IRL was 109.9 +/- 6.4 microm for controls and 97.9 +/- 20.7 microm for retinal dystrophy patients (P = .06). CONCLUSION Eyes with retinal dystrophy had a small (11%) decrease in macular IRL and severe (45%) decrease in macular ORL compared to normal controls.

[1]  Wolfgang Drexler,et al.  Ultra-high resolution optical coherence tomography assessment of photoreceptors in retinitis pigmentosa and related diseases. , 2006, American journal of ophthalmology.

[2]  Maciej Wojtkowski,et al.  High-definition and 3-dimensional imaging of macular pathologies with high-speed ultrahigh-resolution optical coherence tomography. , 2006, Ophthalmology.

[3]  S. Jacobson,et al.  Morphological findings in retinitis pigmentosa with early diffuse rod dysfunction. , 1988, Retina.

[4]  A. Fercher,et al.  Performance of fourier domain vs. time domain optical coherence tomography. , 2003, Optics express.

[5]  J. Fujimoto,et al.  Optical Coherence Tomography , 1991, LEOS '92 Conference Proceedings.

[6]  J. Duker,et al.  Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair. , 2004, Ophthalmology.

[7]  B. Dolan.  Optical Coherence Tomography of Ocular Diseases, 2nd ed , 2005 .

[8]  J. Fujimoto,et al.  Buffered Fourier domain mode locking: Unidirectional swept laser sources for optical coherence tomography imaging at 370,000 lines/s. , 2006, Optics letters.

[9]  A. Fercher,et al.  In vivo human retinal imaging by Fourier domain optical coherence tomography. , 2002, Journal of biomedical optics.

[10]  Changhuei Yang,et al.  Sensitivity advantage of swept source and Fourier domain optical coherence tomography. , 2003, Optics express.

[11]  Angelika Unterhuber,et al.  Assessment of central visual function in Stargardt's disease/fundus flavimaculatus with ultrahigh-resolution optical coherence tomography. , 2005, Investigative ophthalmology & visual science.

[12]  Wolfgang Drexler,et al.  Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathology. , 2005, Ophthalmology.

[13]  James G. Fujimoto,et al.  Optical Coherence Tomography of Ocular Diseases , 1995 .

[14]  A. Milam,et al.  Histopathology of the human retina in retinitis pigmentosa. , 1998, Progress in retinal and eye research.

[15]  G. Ripandelli,et al.  Optical coherence tomography. , 1998, Seminars in ophthalmology.

[16]  J. Duker,et al.  Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography. , 2005, Ophthalmology.

[17]  D E Gaasterland,et al.  The Advanced Glaucoma Intervention Study (AGIS): 1. Study design and methods and baseline characteristics of study patients. , 1994, Controlled clinical trials.

[18]  J. Fujimoto,et al.  Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography. , 2003, Archives of ophthalmology.

[19]  F. Newell.  The American Journal of Ophthalmology , 1862, American journal of ophthalmology.