Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination.
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F. Alt | S. Jin | D. Weaver | Y. Gao | Yijie Gao | Y. Gu | Frederick W. Alt | Yansong Gu | David T. Weaver | Shengfang Jin
[1] P. Jeggo,et al. Molecular and biochemical characterization of xrs mutants defective in Ku80 , 1997, Molecular and cellular biology.
[2] Sandro Santagata,et al. The Homeodomain Region of Rag-1 Reveals the Parallel Mechanisms of Bacterial and V(D)J Recombination , 1996, Cell.
[3] Eugenia Spanopoulou,et al. RAG1 Mediates Signal Sequence Recognition and Recruitment of RAG2 in V(D)J Recombination , 1996, Cell.
[4] J. Danska,et al. Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes , 1996, Molecular and cellular biology.
[5] P. Jeggo,et al. Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[6] F. Alt,et al. The V(D)J recombination defect in the xrs-6 cell line results from a point mutation in the Ku80 gene. , 1996, International immunology.
[7] F. Alt,et al. The Igκ 3′ Enhancer Influences the Ratio of Igκ versus Igλ B Lymphocytes , 1996 .
[8] Molly A Bogue,et al. Ku86-Deficient Mice Exhibit Severe Combined Immunodeficiency and Defective Processing of V(D)J Recombination Intermediates , 1996, Cell.
[9] M. Nussenzweig,et al. Requirement for Ku80 in growth and immunoglobulin V(D)J recombination , 1996, Nature.
[10] R. Moyzis,et al. Genomic structure and chromosomal assignment of the mouse Ku70 gene. , 1996, Genomics.
[11] G. Chu,et al. Ku86 defines the genetic defect and restores X-ray resistance and V(D)J recombination to complementation group 5 hamster cell mutants , 1996, Molecular and cellular biology.
[12] Gratien G. Prefontaine,et al. Sequence-specific DNA binding by Ku autoantigen and its effects on transcription , 1996, Nature.
[13] F. Alt,et al. The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination , 1995, Cell.
[14] S. Jackson,et al. Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[15] Christina A. Cuomo,et al. Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps , 1995, Cell.
[16] D. Weaver,et al. What to do at an end: DNA double-strand-break repair. , 1995, Trends in genetics : TIG.
[17] P. Jeggo,et al. Nomenclature of human genes involved in ionizing radiation sensitivity. , 1995, Mutation research.
[18] F. Alt,et al. Potential targets for autosomal SCID mutations. , 1995, Current opinion in immunology.
[19] D. Ward,et al. Gene for the catalytic subunit of the human DNA-activated protein kinase maps to the site of the XRCC7 gene on chromosome 8. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[20] D. Ramsden,et al. Initiation of V(D)J recombination in a cell-free system , 1995, Cell.
[21] M. Oshimura,et al. Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[22] F. Alt,et al. Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation , 1995, Cell.
[23] M. Oettinger,et al. DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect , 1995, Science.
[24] H. Band,et al. Complementation of the ionizing radiation sensitivity, DNA end binding, and V(D)J recombination defects of double-strand break repair mutants by the p86 Ku autoantigen. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[25] P. Jeggo,et al. DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[26] M. Lieber,et al. Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA. , 1994, Science.
[27] N. Tuteja,et al. Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen. , 1994, The EMBO journal.
[28] F. Alt,et al. Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. , 1994, Science.
[29] J. Leszyk,et al. DNA-dependent ATPase from HeLa cells is related to human Ku autoantigen. , 1994, Biochemistry.
[30] G. Chu,et al. A DNA end-binding factor involved in double-strand break repair and V(D)J recombination , 1994, Molecular and cellular biology.
[31] R. Getts,et al. Absence of a Ku-like DNA end binding activity in the xrs double-strand DNA repair-deficient mutant. , 1994, The Journal of biological chemistry.
[32] C. Kahn,et al. The insulin signaling system. , 1994, The Journal of biological chemistry.
[33] M. Lieber,et al. V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repair , 1993, Molecular and cellular biology.
[34] F. Alt,et al. Impairment of V(D)J recombination in double-strand break repair mutants. , 1993, Science.
[35] S. Jackson,et al. The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen , 1993, Cell.
[36] Rudolf Jaenisch,et al. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality , 1992, Cell.
[37] K. Rajewsky,et al. Generation and analysis of interleukin-4 deficient mice. , 1991, Science.
[38] P. Jeggo,et al. Genetic analysis of ionising radiation sensitive mutants of cultured mammalian cell lines. , 1991, Mutation research.
[39] M. Schlissel,et al. Wild-type V(D)J recombination in scid pre-B cells. , 1990, Molecular and cellular biology.
[40] R. Yenofsky,et al. A mutant neomycin phosphotransferase II gene reduces the resistance of transformants to antibiotic selection pressure. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[41] David Baltimore,et al. The V(D)J recombination activating gene, RAG-1 , 1989, Cell.
[42] W. Reeves,et al. Molecular cloning of cDNA encoding the p70 (Ku) lupus autoantigen. , 1989, The Journal of biological chemistry.
[43] Joins,et al. Isolation of scid pre‐B cells that rearrange kappa light chain genes: formation of normal signal and abnormal coding joins. , 1989, The EMBO journal.
[44] Naomi Rosenberg,et al. The defect in murine severe combined immune deficiency: Joining of signal sequences but not coding segments in V(D)J recombination , 1988, Cell.
[45] F. Alt,et al. The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism , 1988, Cell.
[46] M. Lieber,et al. Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals , 1987, Cell.
[47] J. Steitz,et al. Characterization of the DNA-binding protein antigen Ku recognized by autoantibodies from patients with rheumatic disorders. , 1986, The Journal of biological chemistry.
[48] A. Giaccia,et al. Cell cycle-dependent repair of double-strand DNA breaks in a γ-ray-sensitive Chinese hamster cell , 1985, Somatic cell and molecular genetics.
[49] P. Jeggo,et al. X-ray-sensitive mutants of Chinese hamster ovary cell line. Isolation and cross-sensitivity to other DNA-damaging agents. , 1983, Mutation research.
[50] S. Tonegawa. Somatic generation of antibody diversity , 1983, Nature.
[51] M. Lieber,et al. Molecular Analysis of DNA Rearrangements in the Immune System , 1996, Current Topics in Microbiology and Immunology.
[52] F. Alt,et al. Activities involved in V(D)J recombination. , 1992, Current topics in microbiology and immunology.
[53] Bosma Mj. B and T cell leakiness in the scid mouse mutant. , 1992 .
[54] A. J. Varghese,et al. Cell cycle responses of two X-ray sensitive mutants defective in DNA repair. , 1989, International journal of radiation biology.
[55] S. Nesnow,et al. The genetic toxicology of Gene-Tox non-carcinogens. , 1988, Mutation research.