The deletion model for the origin of receptors

Abstract Receptors play a central role in the control of many biochemical processes. By considering that receptors together with their complementary ligands may be derived from a common parent system, there emerges the possibility of resolving many interesting questions.

[1]  C. Marshall,et al.  Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production , 1986, Nature.

[2]  R. Haslam,et al.  Receptor-induced diacylglycerol formation in permeabilized platelets; possible role for a GTP-binding protein. , 1984, Journal of receptor research.

[3]  Makoto Sato,et al.  A single GTP-binding protein regulates K+-channels coupled with dopamine, histamine and acetylcholine receptors , 1987, Nature.

[4]  S. Cockcroft,et al.  Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase , 1985, Nature.

[5]  C. Stevens Neurotransmission: Are there two functional classes of glutamate receptors? , 1986, Nature.

[6]  R. Osman,et al.  A molecular theory of recognition and activation at a 5-HT receptor based on a quantum chemical approach to structure activity relationships. , 1985, Clinical physiology and biochemistry.

[7]  L. Goodman,et al.  The Pharmacological Basis of Therapeutics , 1941 .

[8]  T. Steitz,et al.  X-ray diffraction studies of enzymes. , 1970, Annual review of biochemistry.

[9]  J. Mulder,et al.  A NEW FACET IN RHODOPSIN PHOTOCHEMISTRY , 1976, Photochemistry and photobiology.

[10]  M. S. Matta,et al.  Proton inventory of the second step of ribonuclease catalysis , 1986 .

[11]  H Weinstein,et al.  Theoretical studies on the activation mechanism of the histamine H2-receptor: the proton transfer between histamine and a receptor model. , 1986, Molecular pharmacology.

[12]  B. Michell,et al.  Biochemistry: G-protein control of inositol phosphate hydrolysis , 1986, Nature.

[13]  A. Lewis [72] Resonance raman spectroscopy of rhodopsin and bacteriorhodopsin: An overview , 1982 .

[14]  Dietrich Suck,et al.  Structure of DNase I at 2.0 Å resolution suggests a mechanism for binding to and cutting DNA , 1986, Nature.

[15]  M. Mishina,et al.  Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor , 1986, Nature.

[16]  H. Bourne GTP-binding proteins: One molecular machine can transduce diverse signals , 1986, Nature.

[17]  K. Kuma,et al.  Similarity of mas and rhodopsin gene products , 1986, Nature.

[18]  R. Osman,et al.  A theoretical investigation of histamine tautomerism. , 1984, Journal of medicinal chemistry.

[19]  C. Wallis,et al.  5-Hydroxytryptamine stimulates inositol phosphate production in a cell-free system from blowfly salivary glands. Evidence for a role of GTP in coupling receptor activation to phosphoinositide breakdown. , 1985, The Journal of biological chemistry.

[20]  Brian K. Kobilka,et al.  Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin , 1986, Nature.

[21]  H. Weinstein,et al.  Tautomerism and the receptor action of histamine: a mechanistic model. , 1976, Molecular pharmacology.