True radiotracers: are we approaching theoretical specific activity with Tc-99m and I-123?

[1]  T. Yen,et al.  Clinical acceptance of a molecular imaging agent: a long march with [99mTc]TRODAT. , 2007, Nuclear medicine and biology.

[2]  M. Brechbiel,et al.  Development of radioimmunotherapeutic and diagnostic antibodies: an inside-out view. , 2007, Nuclear medicine and biology.

[3]  Ying Ma,et al.  An automated one-step one-pot [(18)F]FCWAY synthesis: development and minimization of chemical impurities. , 2007, Nuclear medicine and biology.

[4]  M. Jensen,et al.  Use of 99mTc from a commercial 99Mo/99mTc generator as yield tracer for the determination of 99Tc at low levels , 2007 .

[5]  Thangavel Arunachalam,et al.  177Lu-AMBA: Synthesis and characterization of a selective 177Lu-labeled GRP-R agonist for systemic radiotherapy of prostate cancer. , 2006, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[6]  M. Walter,et al.  Evaluation of [99mTc/EDDA/HYNIC0]octreotide derivatives compared with [111In-DOTA0,Tyr3, Thr8]octreotide and [111In-DTPA0]octreotide: does tumor or pancreas uptake correlate with the rate of internalization? , 2005, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[7]  Flavia Groppi,et al.  On the "artificial" nature of Tc and the "carrier-free" nature of 99mTc from 99Mo/99mTc generators. , 2005, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[8]  M. Travis,et al.  Manufacturing I-123-labelled radiopharmaceuticals. Pitfalls and solutions , 2005 .

[9]  M. Bonardi,et al.  How do we ascertain specific activities in no-carrier-added radionuclide preparations? , 2005 .

[10]  M. Bonardi,et al.  How do we define the concepts specific activity, radioactive concentration, carrier, carrier-free and no-carrier-added? , 2005 .

[11]  C. Birattari,et al.  Cyclotron production and quality control of “high specific activity' radionuclides in “no-carrier-added” form for radioanalytical applications in the life sciences , 2004 .

[12]  H. Ravert,et al.  PET imaging of opioid receptors in pain: progress and new directions. , 2004, Current pharmaceutical design.

[13]  P. Scheibe.  Identifiability analysis of second-order systems. , 2003, Nuclear medicine and biology.

[14]  J. Reubi.  Peptide receptors as molecular targets for cancer diagnosis and therapy. , 2003, Endocrine reviews.

[15]  Donald L. Hayes,et al.  Radiochemical investigations of gastrin-releasing peptide receptor-specific [(99m)Tc(X)(CO)3-Dpr-Ser-Ser-Ser-Gln-Trp-Ala-Val-Gly-His-Leu-Met-(NH2)] in PC-3, tumor-bearing, rodent models: syntheses, radiolabeling, and in vitro/in vivo studies where Dpr = 2,3-diaminopropionic acid and X = H2O or P(CH2 , 2003, Cancer research.

[16]  P. Blower,et al.  Solid-phase synthesis of peptide radiopharmaceuticals using Fmoc-N-epsilon-(hynic-Boc)-lysine, a technetium-binding amino acid: application to Tc-99m-labeled salmon calcitonin. , 2003, Journal of medicinal chemistry.

[17]  M. Welch,et al.  MicroPET imaging with non-conventional isotopes , 2001, 2001 IEEE Nuclear Science Symposium Conference Record (Cat. No.01CH37310).

[18]  T. Quinn,et al.  Radiometallated receptor-avid peptide conjugates for specific in vivo targeting of cancer cells. , 2001, Nuclear medicine and biology.

[19]  S. Jurisson,et al.  Melanoma-targeting properties of (99m)technetium-labeled cyclic alpha-melanocyte-stimulating hormone peptide analogues. , 2000, Cancer research.

[20]  A. Zawadzki,et al.  The quantification of technetium in generator-derived pertechnetate using ICP-MS. , 2000, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[21]  G. Slegers,et al.  Technetium-99m RP527, a GRP analogue for visualisation of GRP receptor-expressing malignancies: a feasibility study , 2000, European Journal of Nuclear Medicine.

[22]  F Dumont,et al.  Biodistribution and dosimetry of (99m)Tc-RP527, a gastrin-releasing peptide (GRP) agonist for the visualization of GRP receptor-expressing malignancies. , 2000, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[23]  T. Waldmann,et al.  Methods to avoid adverse effect of circulating antigen on biodistribution of 125I-labeled antiTac dsFv: preinjection of intact antibody versus clearance of antigen with adivin-biotin system. , 1999, Journal of Nuclear Medicine.

[24]  T. Visser,et al.  Tumour uptake of the radiolabelled somatostatin analogue [DOTA0,TYR3]octreotide is dependent on the peptide amount , 1999, European Journal of Nuclear Medicine.

[25]  K. Markides,et al.  On the use of liquid chromatography with radio- and ultraviolet absorbance detection coupled to mass spectrometry for improved sensitivity and selectivity in determination of specific radioactivity of radiopharmaceuticals. , 1999, Journal of pharmaceutical and biomedical analysis.

[26]  K. Dutschka,et al.  N.c.a. radiosynthesis of [123,124I]beta-CIT, plasma analysis and pharmacokinetic studies with SPECT and PET. , 1995, Nuclear medicine and biology.

[27]  T. Visser,et al.  Effect of dose and specific activity on tissue distribution of indium-111-pentetreotide in rats. , 1995, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[28]  M. Pimm.  Circulating antigen: bad or good for immunoscintigraphy? , 1995, Nuclear medicine and biology.

[29]  W. Scheithauer,et al.  Vasoactive intestinal peptide-receptor imaging for the localization of intestinal adenocarcinomas and endocrine tumors. , 1994, The New England journal of medicine.

[30]  D E Kuhl,et al.  In vivo mapping of cholinergic neurons in the human brain using SPECT and IBVM. , 1994, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[31]  J. Bonnyman.  Effect of milking efficiency on 99Tc content of 99mTc derived from 99mTc generators. , 1983, The International journal of applied radiation and isotopes.

[32]  R. E. Boyd.  Technetium-99m generators--the available options. , 1982, The International journal of applied radiation and isotopes.

[33]  M. Impicciatore,et al.  [Action of bombesine on the human gastrointestinal tract in vitro]. , 1973, L'Ateneo parmense. Acta bio-medica : organo della Societa di medicina e scienze naturali di Parma.

[34]  J. Reubi,et al.  Preclinical evaluation of somatostatin analogs bearing two macrocyclic chelators for high specific activity labeling with radiometals , 2007 .

[35]  M. Jensen,et al.  Use of (99m)Tc from a commercial (99)Mo/(99m)Tc generator as yield tracer for the determination of (99)Tc at low levels. , 2007, Applied Radiation and Isotopes.

[36]  J. Valliant,et al.  A solid-phase labeling strategy for the preparation of technetium and rhenium bifunctional chelate complexes and associated peptide conjugates. , 2006, Bioconjugate chemistry.

[37]  J. Jansen,et al.  Effect of loxiglumide (CR-1505) on bombesin- and meal-stimulated plasma cholecystokinin in man , 2004, European Journal of Clinical Pharmacology.

[38]  H. Levi.  George Hevesy and his concept of radioactive indicators—In retrospect , 2004, European Journal of Nuclear Medicine.

[39]  D. Kiesewetter,et al.  Semi-remote production of Br-76 and preparation of high specific activity radiobrominated pharmaceuticals for PET studies , 2004 .

[40]  F. Groppi,et al.  The new IUPAC project on Terminology, quantities and units concerning production and applications of radionuclides in radiopharmaceutical and radioanalytical chemistry , 2004 .

[41]  H. Gali,et al.  Radiochemical investigations of (99m)Tc-N(3)S-X-BBN[7-14]NH(2): an in vitro/in vivo structure-activity relationship study where X = 0-, 3-, 5-, 8-, and 11-carbon tethering moieties. , 2003, Bioconjugate chemistry.

[42]  D. I. Våge,et al.  The melanocortin receptors: agonists, antagonists, and the hormonal control of pigmentation. , 1996, Recent progress in hormone research.

[43]  O. B. Schaffalitzky de Muckadell,et al.  Flushing and plasma substance P concentration during infusion of synthetic substance P in normal man. , 1986, Scandinavian journal of gastroenterology.

[44]  G. Meinken,et al.  Problems associated with stannous 99mTc-radiopharmaceuticals. , 1977, The International journal of applied radiation and isotopes.