Cocaine and the heart

Cocaine is the second commonest illicit drug used and the most frequent cause of drug related deaths. Its use is associated with both acute and chronic complications that may involve any system, the most common being the cardiovascular system. Cocaine misuse has a major effect in young adult drug users with resulting loss of productivity and undue morbidity with cocaine related cardiac and cerebrovascular effects. Many cocaine users have little or no idea of the risks associated with its use. Patients, health care professionals, and the public should be educated about the dangers and the considerable risks of cocaine use. This review concentrates on the cardiovascular effects of cocaine and their management.

[1]  R. Saldanha,et al.  Warm cardioplegia in cardiac transplantation. , 1997, The Annals of thoracic surgery.

[2]  R. Schwartz,et al.  Dilated cardiomyopathy and cocaine abuse. Report of two cases. , 1986, The American journal of medicine.

[3]  S. Sudman,et al.  Validity of drug use reporting in a high-risk community sample: a comparison of cocaine and heroin survey reports with hair tests. , 1999, American journal of epidemiology.

[4]  R. Preston,et al.  Acute rhabdomyolysis associated with cocaine intoxication. , 1988, The New England journal of medicine.

[5]  R. Hariman,et al.  Cocaine‐Related Sudden Cardiac Death: A Hypothesis Correlating Basic Science and Clinical Observations , 1994, Journal of clinical pharmacology.

[6]  Li Zhu,et al.  Cocaine inhibits human endothelial cell IL-8 production: the role of transforming growth factor-beta. , 1997, Cellular immunology.

[7]  J. Ornato,et al.  Reversibility of cocaine-induced cardiomyopathy. , 1992, American heart journal.

[8]  R. Hoffman,et al.  Cocaine-associated chest pain: one-year follow-up. , 1995, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[9]  A. Bolger,et al.  Acute Aortic Dissection Related to Crack Cocaine , 2002, Circulation.

[10]  Diana B. Petitti,et al.  Stroke and cocaine or amphetamine use. , 1998 .

[11]  Cocaine-induced coronary-artery vasoconstriction. , 1990, The New England journal of medicine.

[12]  G. Modin,et al.  Cocaine use and the risk for endocarditis in intravenous drug users. , 1987, Annals of internal medicine.

[13]  B. Sadler,et al.  Cocaine disposition in humans after intravenous injection, nasal insufflation (snorting), or smoking. , 1989, Drug metabolism and disposition: the biological fate of chemicals.

[14]  T. Fraker,et al.  Cardiovascular complications of cocaine. , 1995, Chest.

[15]  J. Grisso,et al.  Cocaine and tobacco use and the risk of spontaneous abortion. , 1999, The New England journal of medicine.

[16]  G. Larkin,et al.  Validation of a brief observation period for patients with cocaine-associated chest pain. , 2002, The New England journal of medicine.

[17]  R. Kloner,et al.  The effects of acute and chronic cocaine use on the heart. , 1992, Circulation.

[18]  T. Henry,et al.  Cardiac Troponin I and T Concentrations in Patients with Cocaine-Associated Chest Pain , 1996, Annals of clinical biochemistry.

[19]  N. Pandian,et al.  Reversible cardiomyopathy associated with cocaine intoxication. , 1989, Annals of internal medicine.

[20]  H. Webb,et al.  Selective decontamination of the digestive tract. , 1992, New England Journal of Medicine.

[21]  Validation of a brief observation period for patients with cocaine-associated chest pain , 2003 .

[22]  M. Winniford,et al.  Cocaine-induced myocardial infarction in patients with normal coronary arteries. , 1991, Annals of internal medicine.

[23]  R. Hoffman,et al.  The cardiovascular effects of cocaine. , 1991, Annals of emergency medicine.

[24]  A. Gradman Cardiac effects of cocaine: a review. , 1988, The Yale journal of biology and medicine.

[25]  R. Hoffman,et al.  Cocaine-induced myocardial infarction: an analysis and review of the literature. , 1992, The Journal of emergency medicine.

[26]  R. Hoffman,et al.  Use of phentolamine for cocaine-induced myocardial ischemia. , 1992, The New England journal of medicine.

[27]  S. Goldsmith,et al.  Cocaine and chest pain: clinical features and outcome of patients hospitalized to rule out myocardial infarction. , 1991, Annals of internal medicine.

[28]  W. Dick Guidelines 2000 for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care , 2000, Notfall & Rettungsmedizin.

[29]  P. Thompson,et al.  Acute cardiac events temporally related to cocaine abuse. , 1986, The New England journal of medicine.

[30]  M A House,et al.  Cardiovascular effects of cocaine. , 1992, The Journal of cardiovascular nursing.

[31]  Dainia S. Baugh,et al.  Crack-Cocaine-Associated Aortic Dissection in Early Pregnancy , 1999, Angiology.

[32]  R. Silverman,et al.  Cocaine-Associated Myocardial Infarction: Mortality and Complications , 1995 .

[33]  R. Virmani,et al.  Cardiovascular effects of cocaine: an autopsy study of 40 patients. , 1988, American heart journal.

[34]  R. Heaton,et al.  Neuropsychological functioning in cocaine abusers with and without alcohol dependence , 1999, Journal of the International Neuropsychological Society.

[35]  M. Lippmann,et al.  The pulmonary complications of crack cocaine. A comprehensive review. , 1995, Chest.

[36]  W. Wagner,et al.  Cocaine activates platelets and increases the formation of circulating platelet containing microaggregates in humans , 2000, Heart.

[37]  L. Caprino,et al.  Platelet responsiveness and biosynthesis of thromboxane and prostacyclin in response to in vitro cocaine treatment. , 1985, Haemostasis.

[38]  L. Hillis,et al.  Potentiation of cocaine-induced coronary vasoconstriction by beta-adrenergic blockade. , 1990, Annals of internal medicine.

[39]  R. Hoffman,et al.  Prospective multicenter evaluation of cocaine-associated chest pain. Cocaine Associated Chest Pain (COCHPA) Study Group. , 2008, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[40]  R. Hoffman,et al.  Cocaine-associated myocardial infarction. Clinical safety of thrombolytic therapy. Cocaine Associated Myocardial Infarction (CAMI) Study Group. , 1995, Chest.

[41]  D. Klonoff,et al.  Stroke associated with cocaine use. , 1989, Archives of neurology.

[42]  J. Muller,et al.  Triggering of myocardial infarction by cocaine. , 1999, Circulation.

[43]  M. Henzlova,et al.  Apparent reversibility of cocaine-induced congestive cardiomyopathy. , 1991, American heart journal.

[44]  J. Hollander,et al.  Effect of recent cocaine use on the specificity of cardiac markers for diagnosis of acute myocardial infarction. , 1998, American heart journal.

[45]  D. Kidwell,et al.  Cocaine detection in a university population by hair analysis and skin swab testing. , 1997, Forensic science international.

[46]  W. French,et al.  Direct cocaine cardiotoxicity demonstrated by endomyocardial biopsy. , 1989, Archives of pathology & laboratory medicine.

[47]  G. Flaker,et al.  Cardiovascular complications of cocaine use. , 2001, The New England journal of medicine.

[48]  R. Shannon,et al.  Intravenous cocaine induces platelet activation in the conscious dog. , 1995, Circulation.

[49]  D. Orr,et al.  Anaesthesia for laryngoscopy , 1968, Anaesthesia.

[50]  C. Slovis,et al.  Cocaine-related medical problems: consecutive series of 233 patients. , 1990, The American journal of medicine.

[51]  Perry F. Renshaw,et al.  Cocaine decreases relative cerebral blood volume in humans: a dynamic susceptibility contrast magnetic resonance imaging study , 1998, Psychopharmacology.

[52]  Paul Kenny,et al.  Demonstration of Dose-Dependent Global and Regional Cocaine-Induced Reductions in Brain Blood Flow Using a Novel Approach to Quantitative Single Photon Emission Computerized Tomography , 1998, Neuropsychopharmacology.

[53]  Pedro Parraguez Ruiz,et al.  Treatment advances for cocaine-induced ischemic stroke: focus on dihydropyridine-class calcium channel antagonists. , 2001, The American journal of psychiatry.

[54]  M. Frankel,et al.  Biopsy‐proven cerebral vasculitis associated with cocaine abuse , 1990, Neurology.

[55]  Carl J Pepine,et al.  ACC/AHA 2002 guideline update for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction--summary article: a report of the American College of Cardiology/American Heart Association task force on practice guidelines (Committee on the Management of Patients , 2002, Journal of the American College of Cardiology.

[56]  J. W. Schaeffer,et al.  ACC/AHA 2002 guideline update for the management of patients with unstable angina and non–ST-segment elevation myocardial infarction—summary article , 2002 .

[57]  S. Ellahham,et al.  Management of cocaine-induced cardiovascular complications. , 1993, American heart journal.

[58]  W. Kalow,et al.  Metabolism of cocaine in man , 1978, Clinical pharmacology and therapeutics.

[59]  J. Morgan,et al.  Cocaine blockade of the acetylcholine-activated muscarinic K+ channel in ferret cardiac myocytes. , 1998, The Journal of pharmacology and experimental therapeutics.

[60]  H. Willens,et al.  Cardiovascular manifestations of cocaine abuse. A case of recurrent dilated cardiomyopathy. , 1994, Chest.

[61]  G. Billman,et al.  Effects of Cocaine on Cardiac Vagal Tone Before and During Coronary Artery Occlusion: Cocaine Exacerbates the Autonomic Response to Myocardial Ischemia , 1993, Journal of cardiovascular pharmacology.

[62]  R. Hoffman,et al.  Thrombolytic therapy and cocaine-induced myocardial infarction. , 1996, The American journal of emergency medicine.

[63]  A. Nanji,et al.  Asystole and ventricular fibrillation associated with cocaine intoxication. , 1984, Chest.

[64]  J. Hollander The management of cocaine-associated myocardial ischemia. , 1995, The New England journal of medicine.

[65]  D. Coleman Cardiovascular Effects of Cocaine Abuse , 1991, Journal of the American Academy of Nurse Practitioners.

[66]  S. Levine,et al.  Vasospasm and thrombus formation as possible mechanisms of stroke related to alkaloidal cocaine. , 1995, Stroke.

[67]  L. Hillis,et al.  Alleviation of cocaine-induced coronary vasoconstriction with intravenous verapamil. , 1994, The American journal of cardiology.

[68]  R. Hoffman,et al.  Cocaine-associated myocardial infarction. Mortality and complications. Cocaine-Associated Myocardial Infarction Study Group. , 1995, Archives of internal medicine.

[69]  K. Ellenbogen,et al.  Cocaine-induced bradyarrhythmias. , 1992, American heart journal.

[70]  L. Hillis,et al.  Influence of labetalol on cocaine-induced coronary vasoconstriction in humans. , 1993, The American journal of medicine.

[71]  M. Niazi,et al.  Spectrum of Ischemic Colitis in Cocaine Users , 1997, Digestive Diseases and Sciences.

[72]  S. Marks,et al.  Central Nervous System Infarction Related to Cocaine Abuse , 1991, Stroke.