Bronchoscopic phototherapy with hematoporphyrin derivative for treatment of localized bronchogenic carcinoma: a 5-year experience.

Between December 1980 and April 1986 at our institution, 38 patients with cancer that involved the tracheobronchial tree (a total of 40 carcinomas) completed at least one course of hematoporphyrin derivative phototherapy. A complete response occurred in 13 patients (with 14 carcinomas). Eleven of these carcinomas did not recur during follow-up periods that ranged from 3 to 53 months. Three carcinomas recurred at 9, 12, and 35 months, respectively. For 26 carcinomas, the response was less than complete, and alternative therapy was necessary. The carcinomas in patients with a complete response were radiographically occult, were less than 3 cm2 in surface area, and appeared superficial at bronchoscopy. Our experience supports the use of hematoporphyrin derivative phototherapy as an alternative to surgical resection in carefully selected patients.

[1]  T. Dougherty,et al.  Photoradiation therapy in advanced carcinoma of the trachea and bronchus. , 1984, Chest.

[2]  P. Pairolero,et al.  Roentgenographically occult lung cancer: pathologic findings and frequency of multicentricity during a 10-year period. , 1984, Mayo Clinic proceedings.

[3]  T. Dougherty,et al.  Photoradiation therapy for cutaneous and subcutaneous malignancies. , 1981, The Journal of investigative dermatology.

[4]  Preoperative laser photodynamic therapy in combination with operation in lung cancer , 1985 .

[5]  D. Cortese,et al.  Hematoporphyrin derivative phototherapy in the treatment of bronchogenic carcinoma. , 1984, Chest.

[6]  R. E. Thoma,et al.  Interstitial photoradiation therapy for primary solid tumors in pet cats and dogs. , 1981, Cancer research.

[7]  J. H. Kinsey,et al.  Thermal considerations in murine tumor killing using hematoporphyrin derivative phototherapy. , 1983, Cancer research.

[8]  E. Bergstralh,et al.  Roentgenographically occult lung cancer. A ten-year experience. , 1983, The Journal of thoracic and cardiovascular surgery.

[9]  A. M. Olsen,et al.  The use of a derivative of hematoporphyrin in tumor detection. , 1961 .

[10]  H. Kato,et al.  Photoradiation therapy with hematoporphyrin derivative in early and stage 1 lung cancer. , 1984, Chest.

[11]  T J Dougherty,et al.  Photoradiation in the treatment of recurrent breast carcinoma. , 1979, Journal of the National Cancer Institute.

[12]  M. Snell,et al.  Hematoporphyrin derivative: a possible aid in the diagnosis and therapy of carcinoma of the bladder. , 1976, The Journal of urology.

[13]  J. H. Kinsey,et al.  Endoscopic management of lung cancer with hematoporphyrin derivative phototherapy. , 1982, Mayo Clinic proceedings.

[14]  L. O. Svaasand,et al.  Temperature rise during photoradiation therapy of malignant tumors. , 1983, Medical physics.

[15]  T J Dougherty,et al.  Identification of singlet oxygen as the cytotoxic agent in photoinactivation of a murine tumor. , 1976, Cancer research.

[16]  O J Balchum,et al.  Photoradiation therapy of endobronchial lung cancers employing the photodynamic action of hematoporphvrin derivative , 1984, Lasers in surgery and medicine.

[17]  H. Kato,et al.  Hematoporphyrin derivative and laser photoradiation in the treatment of lung cancer. , 1982, Chest.

[18]  J E Kaufman,et al.  Photoradiation therapy for the treatment of malignant tumors. , 1978, Cancer research.