Immunosensing by a Synthetic Ligand-Gated Ion Channel Financial support from the board of the Swiss Federal Institutes of Technology (SPP Minast, 7.06) is acknowledged. We thank G. Corradin for numerous discussions and J. Lakey for critical reading of the manuscript.

Gating of an artificial receptor was monitored for the first time by impedance spectroscopy in tethered lipid bilayer. Subnanomolar concns. of antibody were detected by modulation of the channel activity. The principle of gating by an antibody is particularly attractive because of its general character, and thus opens new possibility of immunosensing. [on SciFinder (R)]

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