Blood manganese content at birth and cord serum prolactin levels.

Manganese (Mn) is both an essential element and, at a high dose, a potent neurotoxin that can interact with dopaminergic neurotransmission. Plasma prolactin (PRL), an indirect indicator of dopaminergic functioning, has been shown to vary with Mn exposure in adults, but little is known about this relation in the developing brain. The objective of this study was to examine the relations between maternal and cord Mn blood concentrations at birth and PRL cord blood levels. Blood Mn levels were determined in 87 pregnant women at delivery, and PRL was measured in the cord blood plasma. Mn cord blood concentration (mean 34.4 microg/l, range 16.7-89.4) was significantly and positively related to cord PRL levels. These findings suggest that Mn accumulation in utero could contribute to PRL level variation in neonates, which, in turn, may influence important developmental parameters.

[1]  A. Iregren,et al.  Manganese neurotoxicity in industrial exposures: proof of effects, critical exposure level, and sensitive tests. , 1999, Neurotoxicology.

[2]  A. Smargiassi,et al.  A comparative study of manganese and lead levels in human umbilical cords and maternal blood from two urban centers exposed to different gasoline additives. , 2002, The Science of the total environment.

[3]  P. Apostoli,et al.  Motor function, olfactory threshold, and hematological indices in manganese-exposed ferroalloy workers. , 1997, Environmental research.

[4]  P He,et al.  [Effects of high-level-manganese sewage irrigation on children's neurobehavior]. , 1994, Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine].

[5]  I. McMillen,et al.  Fetal endocrinology and development--manipulation and adaptation to long-term nutritional and environmental challenges. , 2001, Reproduction.

[6]  T. Leung,et al.  Manganese mineral interactions in brain. , 1999, Neurotoxicology.

[7]  N. Ben-Jonathan,et al.  Dopamine as a prolactin (PRL) inhibitor. , 2001, Endocrine reviews.

[8]  C. Keen,et al.  Nutritional aspects of manganese from experimental studies. , 1999, Neurotoxicology.

[9]  K. Thomas,et al.  Gonadotropins, prolactin, inhibin A, inhibin B, and activin A in human fetal serum from midpregnancy and term pregnancy. , 2000, The Journal of clinical endocrinology and metabolism.

[10]  N Makris,et al.  Possible health effects of high manganese concentration in drinking water. , 1989, Archives of environmental health.

[11]  K. Nicolaides,et al.  Serum prolactin concentration in normal and small for gestational age fetuses , 1992, British journal of obstetrics and gynaecology.

[12]  A. Smargiassi,et al.  Selective Vulnerability of Dopaminergic Systems To Industrial Chemicals: Risk Assessment of Related Neuroendocrine Changes , 1998, Toxicology and industrial health.

[13]  R. Alinovi,et al.  Serum prolactin in subjects occupationally exposed to manganese. , 1996, Annals of clinical and laboratory science.

[14]  G. Hankins,et al.  Prolactin Levels in Umbilical Cord Serum and Its Relation to Fetal Adrenal Activity in Newborns of Women with Pregnancy-Induced Hypertension , 1986, Pediatric Research.

[15]  V. Ganesh,et al.  Water and salt conservation in the human fetus and newborn. I. Evidence for a role of fetal prolactin. , 1989, The Journal of clinical endocrinology and metabolism.

[16]  A. Chicz–DeMet,et al.  Effects of neonatal dietary manganese exposure on brain dopamine levels and neurocognitive functions. , 2002, Neurotoxicology.

[17]  G. Hallmans,et al.  Changes in blood manganese levels during pregnancy in iron supplemented and non supplemented women. , 1995, Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements.

[18]  E. Roti,et al.  Human foetal prolactin but not thyrotropin secretion is decreased by bromocriptine. , 1986, Acta endocrinologica.

[19]  W. D. Phillips,et al.  Prolactin, estradiol, and thyroid hormones in umbilical cord blood of neonates with and without hyaline membrane disease: a study of 405 neonates from midpregnancy to term. , 1982, American journal of obstetrics and gynecology.

[20]  P. Kelly,et al.  Prolactin: the new biology of an old hormone. , 2002, Annual review of physiology.

[21]  B. Friedrichsen,et al.  Regulation of beta-cell mass by hormones and growth factors. , 2001, Diabetes.

[22]  M. Bracken,et al.  Plasma Thyroid Hormones and Prolactin in Premature Infants and Their Mothers after Prenatal Treatment with Thyrotropin-Releasing Hormone , 1992, Pediatric Research.

[23]  Robert Wright,et al.  A child with chronic manganese exposure from drinking water. , 2002, Environmental health perspectives.

[24]  L. Mayes,et al.  Developing brain and in utero cocaine exposure: Effects on neural ontogeny , 1999, Development and Psychopathology.

[25]  D. Grosso,et al.  Relationship of newborn serum prolactin levels to the respiratory distress syndrome and maternal hypertension. , 1980, American journal of obstetrics and gynecology.

[26]  L. Yu-Lee.  Prolactin modulation of immune and inflammatory responses. , 2002, Recent progress in hormone research.

[27]  H. Roels,et al.  Assessment of the permissible exposure level to manganese in workers exposed to manganese dioxide dust. , 1992, British journal of industrial medicine.

[28]  R Tardif,et al.  Nervous system dysfunction among workers with long-term exposure to manganese. , 1994, Environmental research.

[29]  D. Lison,et al.  Prospective study on the reversibility of neurobehavioral effects in workers exposed to manganese dioxide. , 1999, Neurotoxicology.

[30]  P. Gluckman,et al.  Prolactin in umbilical cord blood and the respiratory distress syndrome. , 1978, The Journal of pediatrics.

[31]  A Beuter,et al.  Manganese neurotoxicity, a continuum of dysfunction: results from a community based study. , 1999, Neurotoxicology.

[32]  M. Verity.  Manganese neurotoxicity: a mechanistic hypothesis. , 1999, Neurotoxicology.

[33]  M. Freemark.  Ontogenesis of prolactin receptors in the human fetus: roles in fetal development. , 2001, Biochemical Society transactions.

[34]  A Mutti,et al.  Peripheral biomarkers and exposure to manganese. , 1999, Neurotoxicology.

[35]  K. Shiota,et al.  Hormonal regulation of copper-zinc superoxide dismutase and manganese superoxide dismutase messenger ribonucleic acid in the rat corpus luteum: induction by prolactin and placental lactogens. , 1998, Biology of reproduction.

[36]  Donna Mergler,et al.  Manganese, monoamine metabolite levels at birth, and child psychomotor development. , 2003, Neurotoxicology.