Coagulation disorders following acute head injury

SummaryCoagulation disorders following acute head injury were investigated in 100 patients: 81 patients survived and 19 patients died. Disseminated intravascular coagulation (DIC) was seen in 24%, and occurred most frequently in acute subdural haematoma, followed by contusional haematoma and contusion. Mortality rate of the patients with DIC was 58%. Level of serum fibrin-fibrinogen degradation product (FDP) was correlated with the amount of damaged tissue. The factors which influenced the prognosis for life were evaluated by multivariate analysis: in 100 patients, activated partial thromboplastin time (APTT) was most closely correlated with the prognosis for life, but in 24 patients with DIC, level of serum fibrinogen was most closely correlated with it.

[1]  G. Timberlake,et al.  Medical complications of head injury. , 1993, The Medical clinics of North America.

[2]  W. Pondaag.  Disseminated intravascular coagulation related to outcome in head injury. , 1979, Acta neurochirurgica. Supplementum.

[3]  F. Preston,et al.  Disseminated intravascular coagulation as a consequence of cerebral damage , 1974, Journal of neurology, neurosurgery, and psychiatry.

[4]  Disseminated intravascular coagulation fibrinolytic syndrome following head injury in children : Frequency and prognostic implications , 1982 .

[5]  T. Iba,et al.  [Disseminated intravascular coagulation]. , 2003, Nihon rinsho. Japanese journal of clinical medicine.

[6]  R. Keimowitz,et al.  Disseminated intravascular coagulation associated with massive brain injury. , 1973, Journal of neurosurgery.

[7]  A. Sharp.  Diagnosis and management of disseminated intravascular coagulation. , 1977, British medical bulletin.

[8]  G. Vielvoye,et al.  Hemostasis and computerized tomography in head injury. Their relationship to clinical features. , 1981, Journal of neurosurgery.

[9]  A. Tikk,et al.  The significance of cerebral and systemic disseminated intravascular coagulation in early prognosis of brain injury. , 1979, Acta neurochirurgica. Supplementum.

[10]  C. Vecht,et al.  Disseminated intravascular coagulation and head injury. , 1975, Lancet.

[11]  C. Miller,et al.  Diagnosis and treatment of diffuse intravascular coagulation following cerebral trauma. Case report. , 1975, Journal of neurosurgery.

[12]  L. Auer,et al.  Disturbances of the coagulatory system in patients with severe cerebral trauma II. , 2005, Acta Neurochirurgica.

[13]  L. Auer.  Disturbances of the coagulatory system in patients with severe cerebral trauma. I , 2005, Acta Neurochirurgica.

[14]  A. Nosari,et al.  DEFIBRINATION AND HEAD INJURY , 1974 .

[15]  E. Bowie,et al.  Evaluation of patients with increased fibrinolytic split products (FSP) in their serum. , 1974, Mayo Clinic proceedings.

[16]  B. Drayer,et al.  Disseminated intravascular coagulation and head trauma. Two case studies. , 1975, JAMA.

[17]  T. Kurze,et al.  Defibrination after brain-tissue destruction: A serious complication of head injury. , 1974, The New England journal of medicine.

[18]  T. Astrup.  Assay and Content of Tissue Thromboplastin in Different Organs* , 1965, Thrombosis and Haemostasis.

[19]  K. Winston,et al.  Successful evacuation of subdural hematoma in the presence of severe coagulopathy. , 1982, Neurosurgery.

[20]  M. Netsky,et al.  Disseminated intravascular coagulation following cranial trauma. Case report. , 1980, Journal of neurosurgery.

[21]  B. Jennett,et al.  Assessment of coma and impaired consciousness. A practical scale. , 1974, Lancet.

[22]  M. Druskin,et al.  Afibrinogenemia with severe head trauma. , 1972, JAMA.

[23]  P. Gildenberg,et al.  Delayed and recurrent intracranial hematomas related to disseminated intravascular clotting and fibrinolysis in head injury. , 1980, Neurosurgery.