A freeze dried formulation for the preparation of 99mTc-[V]-DMS complex

A freeze dried kit formulation for the preparation of 99mTc-[V]-DMS complex was developed, requiring a single step labeling procedure. Methods of analysis were also developed permitting identification of radiochemical impurities which may be present in radiopharmaceutical solution. 99mTc-[V]-DMS prepared by the kit method was evaluated in experimental animals and human volunteers. Data demonstrated that the complex formed after kit reconstitution shows tumor seeking properties. Thyroid medullary carcinoma in patients was successfully detected 2 hrs post administration.