COVID-19 diagnostics in context

Understanding the performance of existing COVID-19 tests and different clinical needs can inform development of next-generation tests. The coronavirus disease 2019 (COVID-19) pandemic has highlighted the need for different types of diagnostics, comparative validation of new tests, faster approval by federal agencies, and rapid production of test kits to meet global demands. In this Perspective, we discuss the utility and challenges of current diagnostics for COVID-19.

[1]  Mark S. Anderson,et al.  Test performance evaluation of SARS-CoV-2 serological assays , 2020, medRxiv.

[2]  D. Cummings,et al.  A systematic review of antibody mediated immunity to coronaviruses: antibody kinetics, correlates of protection, and association of antibody responses with severity of disease , 2020, medRxiv.

[3]  Carl H. June,et al.  Cytokine release syndrome in severe COVID-19 , 2020, Science.

[4]  Michael Libman,et al.  Diagnostic Testing for Severe Acute Respiratory Syndrome–Related Coronavirus-2 , 2020, Annals of Internal Medicine.

[5]  P. Vollmar,et al.  Virological assessment of hospitalized patients with COVID-2019 , 2020, Nature.

[6]  Nan Wang,et al.  Quantitative Detection and Viral Load Analysis of SARS-CoV-2 in Infected Patients , 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[7]  Yan Liu,et al.  Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV , 2020, Nature Communications.

[8]  Siew Hoon Lim,et al.  Cross-reaction of sera from COVID-19 patients with SARS-CoV assays. , 2020, medRxiv.

[9]  O. Tsang,et al.  Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study , 2020, The Lancet Infectious Diseases.

[10]  Eric H. Y. Lau,et al.  Temporal dynamics in viral shedding and transmissibility of COVID-19 , 2020, Nature Medicine.

[11]  Ruiyun Li,et al.  Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV-2) , 2020, Science.

[12]  R. Lu,et al.  Detection of SARS-CoV-2 in Different Types of Clinical Specimens. , 2020, JAMA.

[13]  Hannah R. Meredith,et al.  The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application , 2020, Annals of Internal Medicine.

[14]  Sebastian Maurer-Stroh,et al.  Monoclonal antibodies for the S2 subunit of spike of SARS-CoV cross-react with the newly-emerged SARS-CoV-2 , 2020, bioRxiv.

[15]  Q. Tao,et al.  Correlation of Chest CT and RT-PCR Testing in Coronavirus Disease 2019 (COVID-19) in China: A Report of 1014 Cases , 2020, Radiology.

[16]  Lei Liu,et al.  Evaluating the accuracy of different respiratory specimens in the laboratory diagnosis and monitoring the viral shedding of 2019-nCoV infections , 2020, medRxiv.

[17]  Victor M Corman,et al.  Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR , 2020, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

[18]  V. Corman,et al.  Hosts and Sources of Endemic Human Coronaviruses , 2018, Advances in Virus Research.

[19]  J. Druce,et al.  SARS–associated Coronavirus Replication in Cell Lines , 2006, Emerging infectious diseases.

[20]  Y. Leo,et al.  Virus-specific RNA and Antibody from Convalescent-phase SARS Patients Discharged from Hospital , 2004, Emerging infectious diseases.