ICE/CED-3 proteasesin apoptosis.

[1]  G. Cohen,et al.  Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32. , 1996, The Biochemical journal.

[2]  X. Wang,et al.  Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis. , 1996, The EMBO journal.

[3]  P. Amiri,et al.  Requirement of an ICE-Like Protease for Induction of Apoptosis and Ceramide Generation by REAPER , 1996, Science.

[4]  W. Earnshaw,et al.  ICE-related proteases in apoptosis. , 1996, Current opinion in genetics & development.

[5]  C. Faucheu,et al.  Identification of a cysteine protease closely related to interleukin-1 beta-converting enzyme. , 1996, European journal of biochemistry.

[6]  A. Chinnaiyan,et al.  ICE-LAP3, a Novel Mammalian Homologue of the Caenorhabditis elegans Cell Death Protein Ced-3 Is Activated during Fas- and Tumor Necrosis Factor-induced Apoptosis (*) , 1996, The Journal of Biological Chemistry.

[7]  E. Alnemri,et al.  Mch3, a novel human apoptotic cysteine protease highly related to CPP32. , 1995, Cancer research.

[8]  R. Weichselbaum,et al.  Proteolytic activation of protein kinase C delta by an ICE‐like protease in apoptotic cells. , 1995, The EMBO journal.

[9]  C. Schneider,et al.  Microfilament reorganization during apoptosis: the role of Gas2, a possible substrate for ICE‐like proteases. , 1995, The EMBO journal.

[10]  D. Nicholson,et al.  Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B , 1995, Nature.

[11]  J. Mankovich,et al.  Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35. , 1995, Science.

[12]  H. Horvitz,et al.  Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein , 1995, Nature.

[13]  R. Oppenheim,et al.  Peptide inhibitors of the ice protease family arrest programmed cell death of motoneurons in vivo and in vitro , 1995, Neuron.

[14]  M. Tewari,et al.  The Baculovirus p35 Protein Inhibits Fas- and Tumor Necrosis Factor-induced Apoptosis (*) , 1995, The Journal of Biological Chemistry.

[15]  Patrick R. Griffin,et al.  Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis , 1995, Nature.

[16]  E. Alnemri,et al.  Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family. , 1995, Cancer research.

[17]  S. Molineaux,et al.  Molecular Cloning and Pro-apoptotic Activity of ICErelII and ICErelIII, Members of the ICE/CED-3 Family of Cysteine Proteases (*) , 1995, The Journal of Biological Chemistry.

[18]  J. Mankovich,et al.  Identification and Characterization of ICH-2, a Novel Member of the Interleukin-1β-converting Enzyme Family of Cysteine Proteases (*) , 1995, The Journal of Biological Chemistry.

[19]  Muneesh Tewari,et al.  Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase , 1995, Cell.

[20]  W. Fiers,et al.  Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis , 1995, Nature.

[21]  S. Nagata,et al.  Involvement of an ICE-like protease in Fas-mediated apoptosis , 1995, Nature.

[22]  M. Su,et al.  A novel human protease similar to the interleukin‐1 beta converting enzyme induces apoptosis in transfected cells. , 1995, The EMBO journal.

[23]  M. Su,et al.  Interleukin‐1 beta converting enzyme requires oligomerization for activity of processed forms in vivo. , 1995, The EMBO journal.

[24]  M. Su,et al.  Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. , 1995, Science.

[25]  C. Thompson,et al.  Apoptosis in the pathogenesis and treatment of disease , 1995, Science.

[26]  E. Alnemri,et al.  Cloning and Expression of Four Novel Isoforms of Human Interleukin-1β Converting Enzyme with Different Apoptotic Activities (*) , 1995, The Journal of Biological Chemistry.

[27]  E. Wagner,et al.  Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease. , 1995, Genes & development.

[28]  Z. Werb,et al.  Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix , 1995, Science.

[29]  R. Kamen,et al.  Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock , 1995, Cell.

[30]  E. Alnemri,et al.  CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme. , 1994, The Journal of biological chemistry.

[31]  D. K. Miller,et al.  Specific cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death. , 1994, The Journal of biological chemistry.

[32]  Y. Lazebnik,et al.  Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE , 1994, Nature.

[33]  Douglas K. Miller,et al.  IL-1 beta-converting enzyme is present in monocytic cells as an inactive 45-kDa precursor. , 1994, Journal of immunology.

[34]  L. Wang,et al.  Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death , 1994, Cell.

[35]  J. Mankovich,et al.  Crystal structure of the cysteine protease interleukin-1β-converting enzyme: A (p20/p10)2 homodimer , 1994, Cell.

[36]  Mark A. Murcko,et al.  Structure and mechanism of interleukin-lβ converting enzyme , 1994, Nature.

[37]  N. Copeland,et al.  Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme. , 1994, Genes & development.

[38]  Junying Yuan,et al.  Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3 , 1993, Cell.

[39]  Shai Shaham,et al.  The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme , 1993, Cell.

[40]  Y. Lazebnik,et al.  Nuclear events of apoptosis in vitro in cell-free mitotic extracts: a model system for analysis of the active phase of apoptosis , 1993, The Journal of cell biology.

[41]  R. Black,et al.  Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1β converting enzyme , 1992, Cell.

[42]  K. O. Elliston,et al.  A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes , 1992, Nature.

[43]  C. March,et al.  Molecular cloning of the interleukin-1 beta converting enzyme. , 1992, Science.

[44]  A. Wyllie,et al.  Apoptosis: A Basic Biological Phenomenon with Wide-ranging Implications in Tissue Kinetics , 1972, British Journal of Cancer.

[45]  H. Horvitz,et al.  Mechanisms and functions of cell death. , 1991, Annual review of cell biology.