Cerebral Perfusion Response to Hyperoxia

Graded levels of supplemental inspired oxygen were investigated for their viability as a noninvasive method of obtaining intravascular magnetic resonance image contrast. Administered hyperoxia has been shown to be effective as a blood oxygenation level-dependent contrast agent for magnetic resonance imaging (MRI); however, it is known that high levels of inspired fraction of oxygen result in regionally decreased perfusion in the brain potentially confounding the possibility of using hyperoxia as a means of measuring blood flow and volume. Although the effects of hypoxia on blood flow have been extensively studied, the hyperoxic regime between normoxia and 100% inspired oxygen has been only intermittently studied. Subjects were studied at four levels of hyperoxia induced during a single session while perfusion was measured using arterial spin labelling MRI. Reductions in regional perfusion of grey matter were found to occur even at moderate levels of hyperoxia; however, perfusion changes at all oxygen levels were relatively mild (less than 10%) supporting the viability of hyperoxia-induced contrast.

[1]  Xavier Golay,et al.  Determining the longitudinal relaxation time (T1) of blood at 3.0 Tesla , 2004, Magnetic resonance in medicine.

[2]  R R Edelman,et al.  Effect of oxygen inhalation on relaxation times in various tissues , 1997, Journal of magnetic resonance imaging : JMRI.

[3]  Alan C. Evans,et al.  A Three-Dimensional Statistical Analysis for CBF Activation Studies in Human Brain , 1992, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[4]  Stephen M. Smith,et al.  A global optimisation method for robust affine registration of brain images , 2001, Medical Image Anal..

[5]  R. Buxton,et al.  Quantitative imaging of perfusion using a single subtraction (QUIPSS and QUIPSS II) , 1998 .

[6]  S Warach,et al.  A general kinetic model for quantitative perfusion imaging with arterial spin labeling , 1998, Magnetic resonance in medicine.

[7]  Mark W. Woolrich,et al.  Advances in functional and structural MR image analysis and implementation as FSL , 2004, NeuroImage.

[8]  Egill Rostrup,et al.  The relationship between cerebral blood flow and volume in humans , 2005, NeuroImage.

[9]  M. Blinkenberg,et al.  Regional Differences in the CBF and BOLD Responses to Hypercapnia: A Combined PET and fMRI Study , 2000, NeuroImage.

[10]  Michael Brady,et al.  Improved Optimization for the Robust and Accurate Linear Registration and Motion Correction of Brain Images , 2002, NeuroImage.

[11]  Christian Kolbitsch,et al.  The influence of hyperoxia on regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV) and cerebral blood flow velocity in the middle cerebral artery (CBFVMCA) in human volunteers. , 2002, Magnetic resonance imaging.

[12]  John R. Christiansen,et al.  The absorption and dissociation of carbon dioxide by human blood , 1914, The Journal of physiology.

[13]  O Henriksen,et al.  Signal changes in gradient echo images of human brain induced by hypo‐ and hyperoxia , 1995, NMR in biomedicine.

[14]  Maximilian Reiser,et al.  Oxygen‐enhanced MRI of the brain , 2002, Magnetic resonance in medicine.

[15]  A. Jackson,et al.  The effect of hyperoxia on cerebral blood flow: a study in healthy volunteers using magnetic resonance phase-contrast angiography. , 2000, European journal of anaesthesiology.

[16]  Christian Bohr,et al.  Ueber einen in biologischer Beziehung wichtigen Einfluss, den die Kohlensäurespannung des Blutes auf dessen Sauerstoffbindung übt1 , 1904 .

[17]  Stephen M. Smith,et al.  Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm , 2001, IEEE Transactions on Medical Imaging.

[18]  Stephen M. Smith,et al.  Temporal Autocorrelation in Univariate Linear Modeling of FMRI Data , 2001, NeuroImage.

[19]  M. Poulin,et al.  Fast and slow components of cerebral blood flow response to step decreases in end-tidal PCO2 in humans. , 1998, Journal of applied physiology.

[20]  D K Menon,et al.  Hyperoxia and the cerebral hemodynamic responses to moderate hyperventilation , 2003, Acta anaesthesiologica Scandinavica.

[21]  Guy Rachmuth,et al.  The effect of hyperoxygenation on T1 relaxation time in vitro. , 2003, Academic radiology.

[22]  J K Kim,et al.  Tracking oxygen effects on MR signal in blood and skeletal muscle during hyperoxia exposure , 1999, Journal of magnetic resonance imaging : JMRI.

[23]  T. Floyd,et al.  Independent cerebral vasoconstrictive effects of hyperoxia and accompanying arterial hypocapnia at 1 ATA. , 2003, Journal of applied physiology.

[24]  H. Becker,et al.  Effect of different levels of hyperoxia on breathing in healthy subjects. , 1996, Journal of applied physiology.

[25]  J C Gore,et al.  Physiologic basis for BOLD MR signal changes due to hypoxia/hyperoxia: Separation of blood volume and magnetic susceptibility effects , 1997, Magnetic resonance in medicine.

[26]  F. Jensen.  Red blood cell pH, the Bohr effect, and other oxygenation-linked phenomena in blood O2 and CO2 transport. , 2004, Acta physiologica Scandinavica.

[27]  B. Berkowitz,et al.  Role of dissolved plasma oxygen in hyperoxia-induced contrast. , 1997, Magnetic resonance imaging.

[28]  K. Walsh,et al.  Cerebral Oxygen Vasoreactivity and Cerebral Tissue Oxygen Reactivity , 2004 .