Signal transduction via phosphatidylcholine cycles

Abstract Phosphatidylcholine turnover cycles can generate second messengers (including diacylglycerol and arachidonic acid). Guanine nucleotide-binding proteins are implicated in the coupling of agonist receptors to the activation of phospholipases A 2 , C and D. In many instances, these agonists also stimulate the resynthesis of phosphatidylcholine via activation of CTP:phosphocholine cytidylyltransferase.

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