Secondary NOE pathways in 2D NOESY spectra of proteins estimated from homonuclear three-dimensional NOE-NOE nuclear magnetic resonance spectroscopy

Abstract Three-dimensional NOE-NOE intensities are used to estimate second-order τ m contributions to the 2D NOESY intensities. A method to calibrate the 2D and 3D NOE spectra is described which enables comparison of the 2D and 3D intensities. The estimated second-order terms can be used as a direct input into the relaxation-matrix calculations.

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