Immunohistochemical localization of the high‐affinity NGF receptor (gp 140‐trkA) in the adult human dorsal root and sympathetic ganglia and in the nerves and sensory corpuscles supplying digital skin

Background: Nerve growth factor (NGF) is produced in target issues of sympathetic and neural‐crest derived sensory neurons, including skin, to provide them trophic support. The biological effects of NGF on responsive cells are mediated by specific high‐affinity receptors. Recently, a protein tyrosine kinase of ≃ 140 kDa molecular weight, encoded by the proto‐oncogene trkA, has been identified as the high‐affinity NGF receptor (gp140‐trkA). The present work was undertaken to study the localization of gp140‐trkA‐like immunoreactivity (IR) in human peripheral ganglia (sympathetic and dorsal root ganglia), and in glabrous skin.

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