Endoscopic photodynamic therapy with haematoporphyrin derivative in gastroenterology.

Endoscopic photodynamic therapy (PDT) with haematoporphyrin derivative was used in the primary treatment of 69 patients with inoperable gastrointestinal neoplasms. Patients were divided into three groups: 31 with oesophageal squamous cell carcinoma, 17 with adenocarcinoma of the stomach or lower third of the oesophagus and 21 with rectosigmoid adenocarcinoma. After infusion of 2.5-5.0 mg haematoporphyrin derivative per kilogram of body weight, lesions were irradiated using an argon dye laser (632 nm). During a follow-up period averaging 20 months (27.9 months for 35 surviving patients), complete local tumour destruction and negative histology were observed in 32 out of 69 cases. Flow-cytometric analysis of DNA content before and after PDT suggests that a clonal selection occurs in some cases of treatment failure. The results of this open pilot study suggest the potential efficacy of PDT as a curative treatment for selected cases of inoperable gastrointestinal cancers.

[1]  T J Dougherty,et al.  Photodynamic therapy in patients with colorectal cancer , 1986, Cancer.

[2]  D. Cloarec,et al.  Photochemotherapy mediated by hematoporphyrin derivative in gastroenterology. , 1987, European journal of cancer & clinical oncology.

[3]  J. Fried,et al.  Multi-user system for analysis of data from flow cytometry. , 1979, Computer programs in biomedicine.

[4]  B. Clarkson,et al.  Photoradiation models for the clinical ex vivo treatment of autologous bone marrow grafts. , 1987, Blood.

[5]  H. Kato,et al.  Five-year disease-free survival of a lung cancer patient treated only by photodynamic therapy. , 1986, Chest.

[6]  H. Kato,et al.  Photoradiation therapy with hematoporphyrin derivative in early and stage 1 lung cancer. , 1984, Chest.

[7]  D. Cloarec,et al.  Parameters Influencing Photodynamic Selectivity of Normal Progenitors vs Leukemia Cells , 1988 .

[8]  J. H. Kinsey,et al.  Endoscopic management of lung cancer with hematoporphyrin derivative phototherapy. , 1982, Mayo Clinic proceedings.

[9]  J E Kaufman,et al.  Photoradiation therapy for the treatment of malignant tumors. , 1978, Cancer research.

[10]  D. Cortese,et al.  Hematoporphyrin derivative phototherapy in the treatment of bronchogenic carcinoma. , 1984, Chest.

[11]  D. Cortese,et al.  Bronchoscopic phototherapy with hematoporphyrin derivative for treatment of localized bronchogenic carcinoma: a 5-year experience. , 1987, Mayo Clinic proceedings.

[12]  W. Hicks,et al.  Photodynamic therapy for esophageal tumors. , 1989, Archives of surgery.

[13]  H. Tajiri,et al.  Photoradiation therapy in early gastrointestinal cancer. , 1987, Gastrointestinal endoscopy.

[14]  H. C. Robertson,et al.  Hematoporphyrin‐Derivative Fluorescence in Malignant Neoplasms , 1968, Journal of the South Carolina Medical Association.

[15]  L. Vindeløv,et al.  Flow microfluorometric analysis of nuclear DNA in cells from solid tumors and cell suspensions , 1977, Virchows Archiv. B, Cell pathology.

[16]  James S. McCaughan,et al.  Palliation of esophageal malignancy with photoradiation therapy , 1984, Cancer.

[17]  A. M. Olsen,et al.  The use of a derivative of hematoporphyrin in tumor detection. , 1961 .