Immune responses after immunization with plasmid DNA encoding Bet v 1, the major allergen of birch pollen.

[1]  Renz,et al.  Effects of adjuvants on the immune response to allergens in a murine model of allergen inhalation: cholera toxin induces a Th1‐like response to Bet v 1, the major birch pollen allergen , 1998, Clinical and experimental immunology.

[2]  P. Messner,et al.  Bet v 1, the major birch pollen allergen, conjugated to crystalline bacterial cell surface proteins, expands allergen-specific T cells of the Th1/Th0 phenotype in vitro by induction of IL-12. , 1997, International immunology.

[3]  M. Willheim,et al.  Immunological changes during specific immunotherapy of grass pollen allergy: reduced lymphoproliferative responses to allergen and shift from TH2 to TH1 in T‐cell clones specific for Phi p 1, a major grass pollen allergen , 1997, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[4]  S. Johnston,et al.  Biological features of genetic immunization. , 1997, Vaccine.

[5]  D. Klinman,et al.  Contribution of CpG motifs to the immunogenicity of DNA vaccines. , 1997, Journal of immunology.

[6]  R. Webster,et al.  Different T helper cell types and antibody isotypes generated by saline and gene gun DNA immunization. , 1997, Journal of immunology.

[7]  Flemming M. Poulsen,et al.  X-ray and NMR structure of Bet v 1, the origin of birch pollen allergy , 1996, Nature Structural Biology.

[8]  J. Ulmer,et al.  Generation of MHC class I‐restricted cytotoxic T lymphocytes by expression of a viral protein in muscle cells: antigen presentation by non‐muscle cells , 1996, Immunology.

[9]  J. Haynes,et al.  Influenza virus nucleoprotein-specific immunoglobulin G subclass and cytokine responses elicited by DNA vaccination are dependent on the route of vector DNA delivery , 1996, Journal of virology.

[10]  C. Walker,et al.  Induction of cytotoxic T lymphocytes by intramuscular immunization with plasmid DNA is facilitated by bone marrow-derived cells. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[11]  E. Raz,et al.  Immunostimulatory DNA Sequences Necessary for Effective Intradermal Gene Immunization , 1996, Science.

[12]  S. Durham,et al.  Grass pollen immunotherapy inhibits allergen-induced infiltration of CD4+ T lymphocytes and eosinophils in the nasal mucosa and increases the number of cells expressing messenger RNA for interferon-gamma. , 1996, The Journal of allergy and clinical immunology.

[13]  Shau-ku Huang,et al.  Immunoprophylaxis of allergen–induced immunoglobulin E synthesis and airway hyperresponsiveness in vivo by genetic immunization , 1996, Nature Medicine.

[14]  E. Raz,et al.  Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[15]  S. Beaucage,et al.  CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[16]  D. Pardoll,et al.  In vivo cross-priming of MHC class I-restricted antigens requires the TAP transporter. , 1996, Immunity.

[17]  K. Hoffmann‐Sommergruber,et al.  Dissection of immunoglobulin E and T lymphocyte reactivity of isoforms of the major birch pollen allergen Bet v 1: potential use of hypoallergenic isoforms for immunotherapy , 1996, The Journal of experimental medicine.

[18]  R. Valenta,et al.  Identification of allergens in fruits and vegetables: IgE cross-reactivities with the important birch pollen allergens Bet v 1 and Bet v 2 (birch profilin). , 1995, The Journal of allergy and clinical immunology.

[19]  M. Jutel,et al.  Bee venom immunotherapy results in decrease of IL-4 and IL-5 and increase of IFN-gamma secretion in specific allergen-stimulated T cell cultures. , 1995, Journal of immunology.

[20]  G. Bishop,et al.  CpG motifs in bacterial DNA trigger direct B-cell activation , 1995, Nature.

[21]  E. Raz,et al.  Intradermal gene immunization: the possible role of DNA uptake in the induction of cellular immunity to viruses. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[22]  P M Kloetzel,et al.  Interferon gamma stimulation modulates the proteolytic activity and cleavage site preference of 20S mouse proteasomes , 1994, The Journal of experimental medicine.

[23]  E. Gelfand,et al.  Inhibition of IgE production and normalization of airways responsiveness by sensitized CD8 T cells in a mouse model of allergen-induced sensitization. , 1994, Journal of immunology.

[24]  B. Demeneix,et al.  Plasmid DNA is superior to viral vectors for direct gene transfer into adult mouse skeletal muscle. , 1993, Human gene therapy.

[25]  D. Umetsu,et al.  Allergen immunotherapy decreases interleukin 4 production in CD4+ T cells from allergic individuals , 1993, The Journal of experimental medicine.

[26]  A. Goldberg,et al.  Gamma-interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes. , 1993, Nature.

[27]  P. Holt,et al.  The natural immune response to inhaled soluble protein antigens involves major histocompatibility complex (MHC) class I-restricted CD8+ T cell-mediated but MHC class II-restricted CD4+ T cell-dependent immune deviation resulting in selective suppression of immunoglobulin E production , 1993, The Journal of experimental medicine.

[28]  J. Ulmer,et al.  Heterologous protection against influenza by injection of DNA encoding a viral protein. , 1993, Science.

[29]  D. Tang,et al.  Genetic immunization is a simple method for eliciting an immune response , 1992, Nature.

[30]  J. Bousquet,et al.  Differences in clinical and immunologic reactivity of patients allergic to grass pollens and to multiple-pollen species. II. Efficacy of a double-blind, placebo-controlled, specific immunotherapy with standardized extracts. , 1991, The Journal of allergy and clinical immunology.

[31]  S. Durham,et al.  Usefulness of immunotherapy in patients with severe summer hay fever uncontrolled by antiallergic drugs. , 1991, BMJ.

[32]  D. Kraft,et al.  Specificities of IgE and IgG antibodies in patients with birch pollen allergy. , 1989, International archives of allergy and applied immunology.

[33]  J J Cogswell,et al.  Development of IgE and IgG antibodies to food and inhalant allergens in children at risk of allergic disease. , 1985, Archives of disease in childhood.